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Query: NC_017297:2143000:2149954 Clostridium botulinum F str. 230613 chromosome, complete genome

Start: 2149954, End: 2150208, Length: 255

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009699:2142177:214985521498552150109255Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-42171
NC_009698:2012500:202037320203732020627255Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein7e-42169
NC_009697:2012500:202015620201562020410255Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein7e-42169
NC_009495:2085000:209151520915152091769255Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein7e-42169
NC_010516:2093901:209962120996212099875255Clostridium botulinum B1 str. Okra, complete genomehypothetical protein9e-42168
NC_012658:2138791:214594721459472146201255Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein1e-41167
NC_012563:2230403:223823022382302238478249Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-40164
NC_012658:2138791:214662321466232146877255Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein5e-40162
NC_016077:2044876:204992920499292050198270Acidaminococcus intestini RyC-MR95 chromosome, complete genomehypothetical protein2e-2097.4
NC_015311:1612366:161236616123661612665300Prevotella denticola F0289 chromosome, complete genomehypothetical protein1e-0651.6
NC_014387:3227875:324318432431843243501318Butyrivibrio proteoclasticus B316 chromosome 1, complete genomeglutaredoxin-like protein5e-0649.7