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Query: NC_017297:2143000:2144083 Clostridium botulinum F str. 230613 chromosome, complete genome

Start: 2144083, End: 2144364, Length: 282

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009699:2142177:214398021439802144975996Clostridium botulinum F str. Langeland chromosome, complete genomeinternalin7e-30129
NC_010516:2093901:209390120939012094896996Clostridium botulinum B1 str. Okra, complete genomeputative internalin4e-28123
NC_009698:2012500:201469020146902015688999Clostridium botulinum A str. Hall chromosome, complete genomeinternalin3e-25113
NC_009697:2012500:201447320144732015471999Clostridium botulinum A str. ATCC 19397 chromosome, completeinternalin3e-25113
NC_009495:2085000:208583220858322086830999Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeleucine-rich repeat-containing protein3e-25113
NC_012563:2230403:223254122325412233539999Clostridium botulinum A2 str. Kyoto, complete genomeputative internalin4e-25113
NC_012658:2138791:214036821403682141366999Clostridium botulinum Ba4 str. 657 chromosome, complete genomeleucine-rich repeat-containing protein6e-1889.4