Pre_GI: BLASTP Hits

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Query: NC_017297:1280963:1290108 Clostridium botulinum F str. 230613 chromosome, complete genome

Start: 1290108, End: 1291847, Length: 1740

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:1348500:1359458135945813611971740Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein01174
NC_013171:342714:3584753584753602141740Anaerococcus prevotii DSM 20548, complete genomehypothetical protein3e-173608
NC_010003:1444623:1465956146595614677431788Petrotoga mobilis SJ95, complete genomehypothetical protein4e-102372