Pre_GI: BLASTP Hits

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Query: NC_017297:1280963:1284258 Clostridium botulinum F str. 230613 chromosome, complete genome

Start: 1284258, End: 1284836, Length: 579

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:1348500:135361513536151354187573Clostridium botulinum A2 str. Kyoto, complete genomexanthine phosphoribosyltransferase8e-101365
NC_021182:1654903:165683716568371657409573Clostridium pasteurianum BC1, complete genomexanthine phosphoribosyltransferase7e-67253
NC_017179:2513804:253226325322632532835573Clostridium difficile BI1, complete genomexanthine phosphoribosyltransferase3e-60231
NC_013315:2505792:252425125242512524823573Clostridium difficile CD196 chromosome, complete genomexanthine phosphoribosyltransferase3e-60231
NC_013316:2585666:260480726048072605379573Clostridium difficile R20291, complete genomexanthine phosphoribosyltransferase3e-60231
NC_010001:4128034:412803441280344128618585Clostridium phytofermentans ISDg, complete genomexanthine phosphoribosyltransferase1e-56219
NC_018664:1279950:129176012917601292335576Clostridium acidurici 9a chromosome, complete genomexanthine phosphoribosyltransferase Xpt2e-56218
NC_015738:2773552:279034627903462790921576Eggerthella sp. YY7918, complete genomeadenine/guanine phosphoribosyltransferase2e-52204
NC_013410:2037840:204231820423182042899582Fibrobacter succinogenes subsp. succinogenes S85 chromosome,xanthine phosphoribosyltransferase1e-50199
NC_018720:1186058:118931611893161189906591Bifidobacterium asteroides PRL2011 chromosome, complete genomexanthine phosphoribosyltransferase1e-48192
NC_014622:5553628:556722855672285568022795Paenibacillus polymyxa SC2 chromosome, complete genomeadenine/guanine phosphoribosyltransferase3e-45181
NC_010337:1445512:146659614665961467162567Heliobacterium modesticaldum Ice1, complete genomexanthine phosphoribosyltransferase1e-43175
NC_017191:1173989:117876511787651179349585Bacillus amyloliquefaciens XH7 chromosome, complete genomexanthine phosphoribosyltransferase2e-43174
NC_017190:2130651:227971522797152280299585Bacillus amyloliquefaciens LL3 chromosome, complete genomexanthine phosphoribosyltransferase2e-43174
NC_017188:1172181:117718811771881177772585Bacillus amyloliquefaciens TA208 chromosome, complete genomexanthine phosphoribosyltransferase2e-43174
NC_020829:5382500:540188754018875402462576Pseudomonas denitrificans ATCC 13867, complete genomexanthine phosphoribosyltransferase2e-42171
NC_017068:130226:141654141654142229576Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative Xanthine phosphoribosyltransferase2e-42171
NC_014033:675626:685510685510686088579Prevotella ruminicola 23 chromosome, complete genomexanthine phosphoribosyltransferase7e-42169
NC_020209:4549563:457375345737534574322570Pseudomonas poae RE*1-1-14, complete genomexanthine phosphoribosyltransferase3e-39161
NC_014106:244831:246124246124246702579Lactobacillus crispatus ST1, complete genomeXanthine phosphoribosyltransferase2e-37155
NC_009615:1734752:175252817525281753094567Parabacteroides distasonis ATCC 8503 chromosome, complete genomexanthine phosphoribosyltransferase5e-36150
NC_013171:416279:431048431048431626579Anaerococcus prevotii DSM 20548, complete genomexanthine phosphoribosyltransferase6e-34143
NC_008054:245184:250831250831251400570Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, completeXanthine phosphoribosyltransferase2e-33142
NC_009633:168266:171020171020171841822Alkaliphilus metalliredigens QYMF chromosome, complete genomepur operon repressor8e-1063.5
NC_000909:1615927:163770816377081638259552Methanocaldococcus jannaschii DSM 2661, complete genomeadenine phosphoribosyltransferase9e-1063.2
NC_006177:3457637:345887734588773459689813Symbiobacterium thermophilum IAM 14863, complete genomepurine operon repressor2e-0962
NC_014122:967194:977234977234977785552Methanocaldococcus infernus ME chromosome, complete genomephosphoribosyltransferase3e-0961.6
NC_017297:3878540:389411438941143894929816Clostridium botulinum F str. 230613 chromosome, complete genomepur operon repressor1e-0756.2
NC_009698:3647955:366621036662103667025816Clostridium botulinum A str. Hall chromosome, complete genomepur operon repressor1e-0756.2
NC_009697:3753527:376910037691003769915816Clostridium botulinum A str. ATCC 19397 chromosome, completepur operon repressor1e-0756.2
NC_010516:3845942:386424838642483865063816Clostridium botulinum B1 str. Okra, complete genomepur operon repressor1e-0756.2
NC_019978:91483:967949679497618825Halobacteroides halobius DSM 5150, complete genomepur operon repressor2e-0755.8
NC_013061:987744:988646988646989173528Pedobacter heparinus DSM 2366, complete genomeadenine phosphoribosyltransferase3e-0652