Pre_GI: BLASTP Hits

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Query: NC_017297:1280963:1280963 Clostridium botulinum F str. 230613 chromosome, complete genome

Start: 1280963, End: 1281523, Length: 561

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:1348500:135031813503181350878561Clostridium botulinum A2 str. Kyoto, complete genomepncA family protein1e-92338
NC_014328:2518081:253877925387792539345567Clostridium ljungdahlii ATCC 49587 chromosome, complete genomenicotinamidase9e-50196
NC_014011:1264165:127181812718181272399582Aminobacterium colombiense DSM 12261 chromosome, complete genomeNicotinamidase6e-22103
NC_015680:369777:378690378690379235546Pyrococcus yayanosii CH1 chromosome, complete genomepyrazinamidase/nicotinamidase5e-1994
NC_000961:888000:907656907656908198543Pyrococcus horikoshii OT3, complete genomepyrazinamidase/nicotinamidase1e-1892.8
NC_017047:2260118:229055822905582291187630Rahnella aquatilis HX2 chromosome, complete genomenicotinamidase/pyrazinamidase2e-1581.6
NC_015947:223184:239980239980240606627Burkholderia sp. JV3 chromosome, complete genomeNicotinamidase1e-1375.9
NC_013170:917177:925423925423926001579Cryptobacterium curtum DSM 15641, complete genomenicotinamidase-like amidase3e-1374.7
NC_004088:2366000:239016323901632390810648Yersinia pestis KIM, complete genomehypothetical protein5e-1374.3
NC_014121:2514544:251557025155702516211642Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completepyrazinamidase/nicotinamidase6e-1373.9
NC_016822:1431200:148600514860051486646642Shigella sonnei 53G, complete genomenicotinamidase/pyrazinamidase8e-1373.2
NC_019907:773944:788699788699789325627Liberibacter crescens BT-1 chromosome, complete genomenicotinamidase3e-1271.6
NC_008390:2058500:207873620787362079368633Burkholderia cepacia AMMD chromosome 1, complete sequenceNicotinamidase1e-0963.2
NC_010551:2007926:202804620280462028678633Burkholderia ambifaria MC40-6 chromosome 1, complete sequenceNicotinamidase1e-0963.2
NC_015416:1478775:149959714995971500223627Methanosaeta concilii GP-6 chromosome, complete genomeisochorismatase family protein6e-0960.5
NC_015966:2337833:234975223497522350384633Rhodothermus marinus SG0.5JP17-172 chromosome, complete genomeNicotinamidase6e-0857.4
NC_013501:931418:938168938168938800633Rhodothermus marinus DSM 4252, complete genomeNicotinamidase6e-0857
NC_007484:293763:299700299700300365666Nitrosococcus oceani ATCC 19707, complete genomeNicotinamidase2e-0755.5