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Query: NC_017265:3821890:3843888 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Start: 3843888, End: 3845387, Length: 1500

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:438785:4618374618374633361500Yersinia pestis A1122 chromosome, complete genomeputative kinase protein01045
NC_008150:3529430:3551427355142735529261500Yersinia pestis Antiqua, complete genomeputative kinase protein01045
NC_004088:3955933:3978526397852639800251500Yersinia pestis KIM, complete genomehypothetical protein01045
NC_010159:1101241:1124278112427811257201443Yersinia pestis Angola, complete genome0980
NC_006625:144929:1632941632941647931500Klebsiella pneumoniae NTUH-K2044 plasmid pK2044, complete sequenceputative protein kinase0932
NC_009778:1717458:1722846172284617243451500Enterobacter sakazakii ATCC BAA-894, complete genomehypothetical protein0929
NC_008760:27967:5020250202517011500Polaromonas naphthalenivorans CJ2 plasmid pPNAP04, completeserine/threonine protein kinase0731
NC_014033:2410331:2427133242713324286111479Prevotella ruminicola 23 chromosome, complete genomehypothetical protein5e-176617
NC_015275:2712991:2730996273099627322971302Clostridium lentocellum DSM 5427 chromosome, complete genomeserine/threonine protein kinase2e-1894.4
NC_008757:111292:1306141306141320411428Polaromonas naphthalenivorans CJ2 plasmid pPNAP01, completeprotein kinase6e-1582.4
NC_015385:351393:3521423521423534401299Treponema succinifaciens DSM 2489 chromosome, complete genomeserine/threonine protein kinase1e-1481.3
NC_017068:1401352:1441426144142614427271302Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative kinase protein1e-1378.6
NC_012108:1694817:1694817169481716962741458Desulfobacterium autotrophicum HRM2, complete genomeputative kinase1e-1068.6
NC_016940:271500:2737942737942762292436Saprospira grandis str. Lewin chromosome, complete genomeserine/threonine protein kinase3e-1067
NC_017068:1450049:1450049145004914514851437Selenomonas ruminantium subsp. lactilytica TAM6421, completehypothetical protein9e-1065.5
NC_010002:4572573:4592579459257945939221344Delftia acidovorans SPH-1, complete genomeserine/threonine protein kinase8e-0858.9
NC_010170:4463000:4502476450247645038191344Bordetella petrii, complete genomeputative protein kinase8e-0858.9
NC_017355:997089:1013018101301810143791362Helicobacter pylori v225d chromosome, complete genomeprotein kinase C-like protein2e-0757.8