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Query: NC_017265:3821890:3842123 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Start: 3842123, End: 3843856, Length: 1734

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:438785:4600724600724618051734Yersinia pestis A1122 chromosome, complete genomehypothetical protein01186
NC_010159:1101241:1122513112251311242461734Yersinia pestis Angola, complete genomehypothetical protein01186
NC_004088:3955933:3976761397676139784941734Yersinia pestis KIM, complete genomehypothetical protein01186
NC_008150:3529430:3549662354966235513951734Yersinia pestis Antiqua, complete genomehypothetical protein01186
NC_006155:4105542:4125620412562041273681749Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein01149
NC_010634:4045794:4065872406587240676201749Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein01149
NC_006625:144929:1648211648211665541734Klebsiella pneumoniae NTUH-K2044 plasmid pK2044, complete sequencehypothetical protein1e-148527
NC_009778:1717458:1724371172437117260081638Enterobacter sakazakii ATCC BAA-894, complete genomehypothetical protein4e-139495
NC_008760:27967:5179851798535281731Polaromonas naphthalenivorans CJ2 plasmid pPNAP04, completehypothetical protein2e-104380
NC_014033:2410331:2428615242861524299941380Prevotella ruminicola 23 chromosome, complete genomehypothetical protein3e-61236
NC_020418:3022891:302810830281083028437330Morganella morganii subsp. morganii KT, complete genomehypothetical protein4e-0860.5