Pre_GI: BLASTP Hits

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Query: NC_017265:3821890:3826694 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Start: 3826694, End: 3827353, Length: 660

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:438785:4446444446444545319888Yersinia pestis A1122 chromosome, complete genomeputative adhesin2e-107388
NC_017160:643406:6471666471666570539888Yersinia pestis D182038 chromosome, complete genomeputative adhesin2e-107388
NC_014029:699078:7028387028387127259888Yersinia pestis Z176003 chromosome, complete genomeputative adhesin2e-107388
NC_004088:3955933:3961333396133339712209888Yersinia pestis KIM, complete genomefilamentous hemagglutinin2e-107388
NC_003143:645559:6493196493196592069888Yersinia pestis CO92, complete genomeputative adhesin2e-107388
NC_008150:3529430:3534234353423435441219888Yersinia pestis Antiqua, complete genomeputative adhesin2e-107388
NC_009381:427515:4312754312754411629888Yersinia pestis Pestoides F chromosome, complete genomeadhesin2e-107388
NC_005810:3238391:3242151324215132520389888Yersinia pestis biovar Microtus str. 91001, complete genomeputative adhesin2e-107388
NC_017154:640578:6449786449786547759798Yersinia pestis D106004 chromosome, complete genomeputative hemolysin5e-93340
NC_014618:4312295:4325481432548143341358655Enterobacter cloacae SCF1 chromosome, complete genomefilamentous hemagglutinin family outer membrane protein1e-46186
NC_012779:3176820:3192129319212931941051977Edwardsiella ictaluri 93-146, complete genomehypothetical protein1e-34146
NC_012962:2587756:260307226030722603752681Photorhabdus asymbiotica, complete genomehypothetical protein1e-30132
NC_012962:2587756:2593887259388726027968910Photorhabdus asymbiotica, complete genomeputative adhesin/hemagglutinin/hemolysin4e-28124
NC_012962:1661683:168209616820961682773678Photorhabdus asymbiotica, complete genomehypothetical protein3e-1065.5
NC_012962:3499900:353527135352713535738468Photorhabdus asymbiotica, complete genomePutative hemagglutinin/hemolysin pala2e-0962.8
NC_009708:588102:6037866037866075923807Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein1e-0756.2
NC_014306:1981956:2004532200453220057341203Erwinia billingiae Eb661, complete genomehypothetical protein5e-0754.3
NC_013508:876431:8985078985079005041998Edwardsiella tarda EIB202, complete genomefilamentous hemagglutinin family outer membrane protein9e-0753.9