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Query: NC_017265:3821890:3825971 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Start: 3825971, End: 3826198, Length: 228

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:438785:443921443921444148228Yersinia pestis A1122 chromosome, complete genomehypothetical protein3e-37153
NC_010159:1101241:110637711063771106604228Yersinia pestis Angola, complete genome3e-37153
NC_008150:3529430:353351135335113533738228Yersinia pestis Antiqua, complete genomehypothetical protein3e-37153
NC_005810:3238391:325253432525343252761228Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein3e-37153
NC_003143:645559:659702659702659929228Yersinia pestis CO92, complete genomehypothetical protein3e-37153
NC_004088:3955933:396061039606103960837228Yersinia pestis KIM, complete genomehypothetical protein3e-37153
NC_009381:427515:441658441658441885228Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein3e-37153
NC_006155:4105542:4105542410554241081062565Yersinia pseudotuberculosis IP 32953, complete genome3e-0753.9
NC_010634:4045794:4045794404579440483582565Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein3e-0753.9