Pre_GI: BLASTP Hits

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Query: NC_017265:3821890:3825459 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Start: 3825459, End: 3825890, Length: 432

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014554:337268:347501347501347908408Lactobacillus plantarum subsp. plantarum ST-III chromosome,hypothetical protein1e-0858.2
NC_004567:343500:355101355101355508408Lactobacillus plantarum WCFS1, complete genomehypothetical protein1e-0755.1
NC_012962:2587756:260407526040752604488414Photorhabdus asymbiotica, complete genomehypothetical protein8e-26115
NC_017168:438785:443409443409443825417Yersinia pestis A1122 chromosome, complete genomehypothetical protein5e-78289
NC_010159:1101241:110586511058651106011147Yersinia pestis Angola, complete genomehypothetical protein6e-22102
NC_008150:3529430:353299935329993533430432Yersinia pestis Antiqua, complete genomehypothetical protein4e-81299
NC_005810:3238391:325284232528423253273432Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein4e-81299
NC_003143:645559:660010660010660441432Yersinia pestis CO92, complete genomehypothetical protein4e-81299
NC_004088:3955933:396009839600983960529432Yersinia pestis KIM, complete genomehypothetical protein4e-81299