Pre_GI: BLASTP Hits

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Query: NC_017265:2586729:2616639 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Start: 2616639, End: 2617877, Length: 1239

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:3977767:4007683400768340089211239Yersinia pestis A1122 chromosome, complete genomeputative hydroxymethylglutaryl-coenzyme A synthase0855
NC_008150:844727:8620558620558632931239Yersinia pestis Antiqua, complete genomeputative hydroxymethylglutaryl-coenzyme A synthase0855
NC_003143:1630000:1650150165015016513881239Yersinia pestis CO92, complete genomeputative hydroxymethylglutaryl-coenzyme A synthase0855
NC_008149:2802392:2832302283230228335401239Yersinia pestis Nepal516, complete genomehydroxymethylglutaryl-coenzyme A synthase0855
NC_010465:2820500:2861462286146228627001239Yersinia pseudotuberculosis YPIII, complete genomeHydroxymethylglutaryl-coenzyme A synthase domain protein0855
NC_004088:2966331:2996238299623829974761239Yersinia pestis KIM, complete genomehydroxymethylglutaryl-coenzyme A synthase0855
NC_005810:1467772:1479061147906114802991239Yersinia pestis biovar Microtus str. 91001, complete genomeputative hydroxymethylglutaryl-coenzyme A synthase0855
NC_006155:1756000:1769548176954817707861239Yersinia pseudotuberculosis IP 32953, complete genomeputative hydroxymethylglutaryl-coenzyme A synthase0855
NC_017160:1628500:1642228164222816434661239Yersinia pestis D182038 chromosome, complete genomeputative hydroxymethylglutaryl-coenzyme A synthase0855
NC_017154:1644404:1661733166173316629711239Yersinia pestis D106004 chromosome, complete genomeputative hydroxymethylglutaryl-coenzyme A synthase0855
NC_014029:1702338:1719666171966617209041239Yersinia pestis Z176003 chromosome, complete genomeputative hydroxymethylglutaryl-coenzyme A synthase0855
NC_009708:2788855:2849918284991828511561239Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehydroxymethylglutaryl-coenzyme A synthase0855
NC_010634:1755548:1769796176979617710341239Yersinia pseudotuberculosis PB1/+, complete genomehydroxymethylglutaryl-coenzyme A synthase0855
NC_009381:1682000:1713577171357717148151239Yersinia pestis Pestoides F chromosome, complete genomeputative hydroxymethylglutaryl-coenzyme A synthase0851
NC_010159:3120642:3132369313236931335621194Yersinia pestis Angola, complete genomeputative hydroxymethylglutaryl-coenzyme A synthase0826
NC_009727:1899876:1907283190728319085211239Coxiella burnetii Dugway 7E9-12, complete genomehydroxymethylglutaryl-CoA synthase4e-68258
NC_020410:1684192:1701926170192617031881263Bacillus amyloliquefaciens subsp. plantarum UCMB5036 complete3-hydroxy-3-methylglutaryl CoA synthase4e-61235
NC_011884:2817054:2838841283884128401001260Cyanothece sp. PCC 7425, complete genomeHydroxymethylglutaryl-coenzyme A synthase domain protein3e-60232
NC_012880:1613485:1627374162737416286361263Dickeya dadantii Ech703, complete genomeHydroxymethylglutaryl-CoA synthase1e-53211
NC_016023:1143130:1152116115211611533001185Bacillus coagulans 36D1 chromosome, complete genomehydroxymethylglutaryl-CoA synthase6e-39162
NC_015954:2873402:2883611288361128849481338Halophilic archaeon DL31 chromosome, complete genomeHydroxymethylglutaryl-CoA synthase3e-28126
NC_010673:703816:7302087302087314641257Borrelia hermsii DAH, complete genomehydroxymethylglutaryl-CoA synthase8e-21101
NC_020388:578500:5841585841585854951338Natronomonas moolapensis 8.8.11 complete genomehydroxymethylglutaryl-CoA synthase2e-20100
NC_003901:1027183:1029422102942210304711050Methanosarcina mazei Go1, complete genomehypothetical protein6e-2099
NC_008710:703740:7275887275887288801293Borrelia turicatae 91E135, complete genomehydroxymethylglutaryl-CoA synthase3e-1790.1
NC_007681:121150:1315931315931326331041Methanosphaera stadtmanae DSM 3091, complete genomepredicted 3-hydroxy-3-methylglutaryl CoA synthase1e-1584.7
NC_000961:597385:6024296024296034811053Pyrococcus horikoshii OT3, complete genomehypothetical protein1e-1377.8
NC_015474:1185478:1188357118835711894091053Pyrococcus sp. NA2 chromosome, complete genomehypothetical protein9e-1375.1
NC_003364:1282000:1292783129278312938351053Pyrobaculum aerophilum str. IM2, complete genomehypothetical protein1e-1274.7
NC_000909:1517461:1524601152460115256381038Methanocaldococcus jannaschii DSM 2661, complete genomehypothetical protein1e-1274.7
NC_015562:1460124:1480006148000614810521047Methanotorris igneus Kol 5 chromosome, complete genomehypothetical protein3e-1273.6
NC_009033:1283645:1296008129600812970661059Staphylothermus marinus F1, complete genomeputative hydroxymethylglutaryl-CoA synthase4e-1169.7
NC_003413:916398:9312359312359322871053Pyrococcus furiosus DSM 3638, complete genomehypothetical protein6e-1168.9
NC_013926:321122:3423253423253433681044Aciduliprofundum boonei T469 chromosome, complete genomehydroxymethylglutaryl-CoA synthase2e-1067
NC_015518:1160430:1174901117490111759471047Acidianus hospitalis W1 chromosome, complete genomehydroxymethylglutaryl-CoA synthase3e-1066.6
NC_015847:1261276:1285431128543112864801050Methanococcus maripaludis XI chromosome, complete genomehypothetical protein4e-1066.2
NC_009637:438037:4672844672844683331050Methanococcus maripaludis C7 chromosome, complete genomehypothetical protein5e-0859.3