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Query: NC_017265:2586729:2613855 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Start: 2613855, End: 2614295, Length: 441

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008150:844727:865616865616866077462Yersinia pestis Antiqua, complete genomehypothetical protein3e-83306
NC_006155:1756000:177313017731301773570441Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein5e-83305
NC_009708:2788855:284713428471342847574441Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein5e-83305
NC_005810:1467772:148259514825951483083489Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein4e-83305
NC_003143:1630000:165368416536841654172489Yersinia pestis CO92, complete genomehypothetical protein4e-83305
NC_008149:2802392:282951828295182830006489Yersinia pestis Nepal516, complete genomehypothetical protein4e-83305
NC_004088:2966331:299345429934542993942489Yersinia pestis KIM, complete genomehypothetical protein4e-83305
NC_009381:1682000:171079317107931711281489Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein4e-83305
NC_017168:3977767:400489940048994005387489Yersinia pestis A1122 chromosome, complete genomehypothetical protein4e-83305
NC_010634:1755548:177348617734861773818333Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein9e-60228
NC_010159:3120642:313601431360143136346333Yersinia pestis Angola, complete genomehypothetical protein9e-60228
NC_010465:2820500:285867828586782859010333Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein9e-60228
NC_014029:1702338:172335617233561723688333Yersinia pestis Z176003 chromosome, complete genomehypothetical protein9e-60228
NC_017154:1644404:166542316654231665755333Yersinia pestis D106004 chromosome, complete genomehypothetical protein9e-60228
NC_017160:1628500:164591816459181646250333Yersinia pestis D182038 chromosome, complete genomehypothetical protein9e-60228
NC_010508:1980689:199691219969121997364453Burkholderia cenocepacia MC0-3 chromosome 1, complete sequencehypothetical protein4e-0960.1
NC_008268:442657:458487458487458969483Rhodococcus sp. RHA1, complete genomehypothetical protein2e-0754.7