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Query: NC_017265:2586729:2613569 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Start: 2613569, End: 2613817, Length: 249

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:3977767:400461340046134004861249Yersinia pestis A1122 chromosome, complete genomeputative acyl carrier protein1e-39161
NC_010159:3120642:313638431363843136632249Yersinia pestis Angola, complete genomeputative acyl carrier protein1e-39161
NC_008150:844727:866115866115866363249Yersinia pestis Antiqua, complete genomeputative acyl carrier protein1e-39161
NC_010634:1755548:177385617738561774104249Yersinia pseudotuberculosis PB1/+, complete genomeputative acyl carrier protein1e-39161
NC_008149:2802392:282923228292322829480249Yersinia pestis Nepal516, complete genomeacyl carrier protein1e-39161
NC_010465:2820500:285838228583822858630249Yersinia pseudotuberculosis YPIII, complete genomeputative acyl carrier protein1e-39161
NC_005810:1467772:148312114831211483369249Yersinia pestis biovar Microtus str. 91001, complete genomeputative acyl carrier protein1e-39161
NC_003143:1630000:165421016542101654458249Yersinia pestis CO92, complete genomeputative acyl carrier protein1e-39161
NC_009708:2788855:284684828468482847096249Yersinia pseudotuberculosis IP 31758 chromosome, complete genomeacyl carrier protein1e-39161
NC_006155:1756000:177360817736081773856249Yersinia pseudotuberculosis IP 32953, complete genomeputative acyl carrier protein1e-39161