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Query: NC_017265:2586729:2593545 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Start: 2593545, End: 2594015, Length: 471

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:3977767:398458339845833985053471Yersinia pestis A1122 chromosome, complete genomehypothetical protein6e-88322
NC_004088:2966331:297314729731472973617471Yersinia pestis KIM, complete genomehypothetical protein6e-88322
NC_008149:2802392:280920828092082809678471Yersinia pestis Nepal516, complete genomehypothetical protein6e-88322
NC_005810:1467772:150292315029231503393471Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein6e-88322
NC_008150:844727:887882887882888352471Yersinia pestis Antiqua, complete genomehypothetical protein6e-88322
NC_003143:1630000:167401816740181674488471Yersinia pestis CO92, complete genomehypothetical protein6e-88322
NC_011149:3187022:319843331984333198939507Salmonella enterica subsp. enterica serovar Agona str. SL483,hypothetical protein1e-21102
NC_003198:3126548:313788031378803138506627Salmonella enterica subsp. enterica serovar Typhi str. CT18,hypothetical protein1e-21102
NC_004631:3112043:312337531233753124001627Salmonella enterica subsp. enterica serovar Typhi Ty2, completehypothetical protein1e-21102
NC_006511:3079512:309085530908553091481627Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCChypothetical protein1e-21102
NC_011147:3075186:308652930865293087155627Salmonella enterica subsp. enterica serovar Paratyphi A strhypothetical protein1e-21102
NC_016832:3100683:311213531121353112641507Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12,hypothetical protein1e-21101
NC_013956:4579759:458576845857684586472705Pantoea ananatis LMG 20103 chromosome, complete genomehypothetical protein1e-1375.5