Pre_GI: BLASTP Hits

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Query: NC_017265:1000342:1018358 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Start: 1018358, End: 1019314, Length: 957

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:199381:216270216270217226957Yersinia pestis A1122 chromosome, complete genomegeneral secretion pathway protein K0652
NC_008150:513783:531796531796532752957Yersinia pestis Antiqua, complete genomegeneral secretion pathway protein K0652
NC_010159:3448490:346221134622113463167957Yersinia pestis Angola, complete genomegeneral secretion pathway protein K0652
NC_003143:875367:888048888048889004957Yersinia pestis CO92, complete genomegeneral secretion pathway protein K0652
NC_005810:3142384:316040331604033161359957Yersinia pestis biovar Microtus str. 91001, complete genomegeneral secretion pathway protein K0652
NC_008149:3373229:338591033859103386866957Yersinia pestis Nepal516, complete genomegeneral secretion pathway protein K0652
NC_004088:3505383:351807235180723519028957Yersinia pestis KIM, complete genomehypothetical protein0652
NC_009381:775357:792245792245793201957Yersinia pestis Pestoides F chromosome, complete genomegeneral secretion pathway protein K0652
NC_017154:1089044:110705811070581108014957Yersinia pestis D106004 chromosome, complete genomegeneral secretion pathway protein K0652
NC_006155:3596120:360881336088133609769957Yersinia pseudotuberculosis IP 32953, complete genomeGeneral secretion pathway protein K3e-175613
NC_010634:3509880:352257335225733523529957Yersinia pseudotuberculosis PB1/+, complete genomegeneral secretion pathway protein K3e-175613
NC_017160:1092839:110979011097901110686897Yersinia pestis D182038 chromosome, complete genomegeneral secretion pathway protein K1e-174612
NC_014029:1146900:116497311649731165869897Yersinia pestis Z176003 chromosome, complete genomegeneral secretion pathway protein K1e-174612
NC_009708:1131500:114841111484111149367957Yersinia pseudotuberculosis IP 31758 chromosome, complete genomegeneral secretion pathway protein K3e-169594
NC_010465:1118147:113686911368691137825957Yersinia pseudotuberculosis YPIII, complete genomegeneral secretion pathway protein K3e-167587
NC_015224:1067390:108564510856451086592948Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,general secretion pathway protein K2e-33143
NC_008800:3642679:365611636561163657057942Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,general secretion pathway protein K1e-31137
NC_020064:3998715:405359440535944054550957Serratia marcescens FGI94, complete genometype II secretory pathway, component PulK2e-1789.7
NC_017047:370837:370837370837371823987Rahnella aquatilis HX2 chromosome, complete genomegeneral secretory pathway component, cryptic2e-0963.2
NC_015061:366552:368183368183369169987Rahnella sp. Y9602 chromosome, complete genomegeneral secretory pathway component, cryptic2e-0963.2
NC_016818:362548:375932375932376918987Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, completetype II secretory pathway, component PulK4e-0652.4