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Query: NC_017265:1000342:1015167 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Start: 1015167, End: 1015367, Length: 201

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:199381:213085213085213279195Yersinia pestis A1122 chromosome, complete genomegeneral secretion pathway protein F1e-29128
NC_005810:3142384:3157211315721131584191209Yersinia pestis biovar Microtus str. 91001, complete genomeputative general protein secretion protein4e-2096.7
NC_009708:1131500:1145225114522511464271203Yersinia pseudotuberculosis IP 31758 chromosome, complete genomegeneral secretion pathway protein F4e-1993.2
NC_010465:1118147:1133683113368311348851203Yersinia pseudotuberculosis YPIII, complete genometype II secretion system protein4e-1993.2
NC_010159:3448490:3465151346515134663531203Yersinia pestis Angola, complete genomegeneral secretion pathway protein F4e-1993.2
NC_010634:3509880:3525513352551335267151203Yersinia pseudotuberculosis PB1/+, complete genometype II secretion system protein4e-1993.2
NC_006155:3596120:3611753361175336129551203Yersinia pseudotuberculosis IP 32953, complete genomeputative general secretion pathway protein F.5e-1993.2