Pre_GI: BLASTP Hits

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Query: NC_017265:1000342:1011172 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Start: 1011172, End: 1011675, Length: 504

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:199381:209054209054209587534Yersinia pestis A1122 chromosome, complete genomegeneral secretion pathway protein C1e-92338
NC_009381:775357:785029785029785562534Yersinia pestis Pestoides F chromosome, complete genomegeneral secretion pathway protein C1e-92338
NC_004088:3505383:352571135257113526244534Yersinia pestis KIM, complete genomehypothetical protein1e-92338
NC_005810:3142384:315318631531863153719534Yersinia pestis biovar Microtus str. 91001, complete genomegeneral secretion pathway protein C1e-92338
NC_008149:3373229:339354933935493394082534Yersinia pestis Nepal516, complete genomegeneral secretion pathway protein C1e-92338
NC_008150:513783:524580524580525113534Yersinia pestis Antiqua, complete genomegeneral secretion pathway protein C1e-92338
NC_010465:1118147:112968211296821130185504Yersinia pseudotuberculosis YPIII, complete genomegeneral secretion pathway protein C1e-92338
NC_003143:875367:895687895687896190504Yersinia pestis CO92, complete genomegeneral secretion pathway protein C1e-92338
NC_010634:3509880:353021335302133530716504Yersinia pseudotuberculosis PB1/+, complete genomegeneral secretion pathway protein C4e-92336
NC_009708:1131500:114122411412241141727504Yersinia pseudotuberculosis IP 31758 chromosome, complete genomegeneral secretion pathway protein C-like protein4e-92336
NC_006155:3596120:361645336164533616986534Yersinia pseudotuberculosis IP 32953, complete genomeGeneral secretion pathway protein C4e-92336
NC_017160:1092839:110264611026461103047402Yersinia pestis D182038 chromosome, complete genomegeneral secretion pathway protein C8e-72268
NC_017154:1089044:109997310999731100374402Yersinia pestis D106004 chromosome, complete genomegeneral secretion pathway protein C8e-72268
NC_014029:1146900:115782911578291158230402Yersinia pestis Z176003 chromosome, complete genomegeneral secretion pathway protein C8e-72268
NC_010159:3448490:346985134698513470126276Yersinia pestis Angola, complete genomegeneral secretion pathway protein C homolog3e-46184
NC_008800:3642679:366320736632073663728522Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,general secretion pathway protein C5e-1477
NC_015224:1067390:107897410789741079495522Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,general secretion pathway protein C7e-1476.6