Pre_GI: BLASTN Hits

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Query: NC_017179:905347 Clostridium difficile BI1, complete genome

Start: 905347, End: 925601, Length: 20255

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_013316:89178289178291434722566Clostridium difficile R20291, complete genome08921BLASTN svgBLASTP svg
NC_009089:96595996595998833722379Clostridium difficile 630, complete genome08683BLASTN svgBLASTP svg
NC_003366:12878312878314709918317Clostridium perfringens str. 13, complete genome5e-23117BLASTN svgBLASTP svg
NC_008593:15131071513107153682423718Clostridium novyi NT, complete genome3e-21111BLASTN svgBLASTP svg
NC_009922:86826286826289020421943Alkaliphilus oremlandii OhILAs, complete genome1e-20109BLASTN svgBLASTP svg
NC_004557:25524182552418257431921902Clostridium tetani E88, complete genome3e-18101BLASTN svgBLASTP svg
NC_021182:14735351473535149659923065Clostridium pasteurianum BC1, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_014328:26435882643588266721023623Clostridium ljungdahlii ATCC 49587 chromosome, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_012563:24660002466000248852922530Clostridium botulinum A2 str. Kyoto, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_010516:23740002374000239681422815Clostridium botulinum B1 str. Okra, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_010516:34660003466000348809922100Clostridium botulinum B1 str. Okra, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_014393:36509573650957366964218686Clostridium cellulovorans 743B chromosome, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_010723:37174137174139352221782Clostridium botulinum E3 str. Alaska E43, complete genome2e-0971.9BLASTN svgBLASTP svg
NC_009922:94453894453896923624699Alkaliphilus oremlandii OhILAs, complete genome2e-0971.9BLASTN svgBLASTP svg
NC_012563:37298173729817376659036774Clostridium botulinum A2 str. Kyoto, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_010516:35450173545017356809923083Clostridium botulinum B1 str. Okra, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_010674:37062937062939810727479Clostridium botulinum B str. Eklund 17B, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_014328:22034372203437222518421748Clostridium ljungdahlii ATCC 49587 chromosome, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_021182:29653952965395298850023106Clostridium pasteurianum BC1, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_014330:1113145*1113145114959936455Brachyspira pilosicoli 95/1000 chromosome, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_008262:24980002498000252144223443Clostridium perfringens SM101, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_020291:49100049100051106420065Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome9e-0660BLASTN svgBLASTP svg