Pre_GI: BLASTN Hits

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Query: NC_017179:4023139 Clostridium difficile BI1, complete genome

Start: 4023139, End: 4056599, Length: 33461

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_013316:40959054095905412999634092Clostridium difficile R20291, complete genome034950BLASTN svgBLASTP svg
NC_009089:3935500*3935500397916543666Clostridium difficile 630, complete genome03590BLASTN svgBLASTP svg
NC_009089:42807542807546635638282Clostridium difficile 630, complete genome03313BLASTN svgBLASTP svg
NC_015977:29669712966971299209925129Roseburia hominis A2-183 chromosome, complete genome01790BLASTN svgBLASTP svg
NC_009089:58165558165560656324909Clostridium difficile 630, complete genome5e-30141BLASTN svgBLASTP svg
NC_021175:15976131597613162110823496Streptococcus oligofermentans AS 1.3089, complete genome7e-20107BLASTN svgBLASTP svg
NC_013895:13328321332832138009947268Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, complete7e-20107BLASTN svgBLASTP svg
NC_002758:43446243446245281818357Staphylococcus aureus subsp. aureus Mu50, complete genome5e-18101BLASTN svgBLASTP svg
NC_009089:38898113889811392148531675Clostridium difficile 630, complete genome1e-1593.7BLASTN svgBLASTP svg
NC_009089:12830001283000132421841219Clostridium difficile 630, complete genome1e-1593.7BLASTN svgBLASTP svg
NC_013798:17787581778758180316524408Streptococcus gallolyticus UCN34, complete genome4e-1591.7BLASTN svgBLASTP svg
NC_015385:2050648*2050648208291832271Treponema succinifaciens DSM 2489 chromosome, complete genome3e-1385.7BLASTN svgBLASTP svg
NC_004668:2198027*2198027227009972073Enterococcus faecalis V583, complete genome1e-0973.8BLASTN svgBLASTP svg
NC_013798:17441181744118176331619199Streptococcus gallolyticus UCN34, complete genome2e-0869.9BLASTN svgBLASTP svg
NC_013316:89178289178291434722566Clostridium difficile R20291, complete genome3e-0765.9BLASTN svgBLASTP svg