Pre_GI: BLASTN Hits

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Query: NC_017179:3540739 Clostridium difficile BI1, complete genome

Start: 3540739, End: 3560937, Length: 20199

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_013316:23096942309694233224722554Clostridium difficile R20291, complete genome01526BLASTN svgBLASTP svg
NC_008593:555463*55546357939123929Clostridium novyi NT, complete genome9e-148531BLASTN svgBLASTP svg
NC_013192:107672*10767213303725366Leptotrichia buccalis DSM 1135, complete genome8e-108398BLASTN svgBLASTP svg
NC_010674:61596361596363966223700Clostridium botulinum B str. Eklund 17B, complete genome9e-74285BLASTN svgBLASTP svg
NC_010723:57525457525460199426741Clostridium botulinum E3 str. Alaska E43, complete genome5e-66260BLASTN svgBLASTP svg
NC_020291:5641444*5641444566381622373Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome1e-54222BLASTN svgBLASTP svg
NC_012563:32881243288124330917721054Clostridium botulinum A2 str. Kyoto, complete genome6e-44186BLASTN svgBLASTP svg
NC_010520:31205003120500313949618997Clostridium botulinum A3 str. Loch Maree, complete genome3e-36161BLASTN svgBLASTP svg
NC_013316:40959054095905412999634092Clostridium difficile R20291, complete genome3e-18101BLASTN svgBLASTP svg
NC_021182:43435143435145489320543Clostridium pasteurianum BC1, complete genome2e-1695.6BLASTN svgBLASTP svg
NC_021182:40112940112942526224134Clostridium pasteurianum BC1, complete genome6e-1383.8BLASTN svgBLASTP svg
NC_019908:24015772401577244617744601Brachyspira pilosicoli P43/6/78 chromosome, complete genome6e-1383.8BLASTN svgBLASTP svg
NC_018604:22535392253539227800524467Brachyspira pilosicoli WesB complete genome6e-1383.8BLASTN svgBLASTP svg
NC_014330:76823276823281309944868Brachyspira pilosicoli 95/1000 chromosome, complete genome6e-1383.8BLASTN svgBLASTP svg
NC_010674:11702641170264119243322170Clostridium botulinum B str. Eklund 17B, complete genome3e-1281.8BLASTN svgBLASTP svg
NC_014328:3294086*3294086331239118306Clostridium ljungdahlii ATCC 49587 chromosome, complete genome3e-1281.8BLASTN svgBLASTP svg
NC_012925:14000014000016217622177Streptococcus suis P1/7, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_007350:1971762*1971762199495223191Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305,1e-1179.8BLASTN svgBLASTP svg
NC_013316:3056925*3056925307934422420Clostridium difficile R20291, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_009089:3142976*3142976316557022595Clostridium difficile 630, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_010336:1468760*1468760149027221513Francisella philomiragia subsp. philomiragia ATCC 25017, complete6e-0763.9BLASTN svgBLASTP svg
NC_007530:4853740*4853740487494821209Bacillus anthracis str. 'Ames Ancestor', complete genome2e-0661.9BLASTN svgBLASTP svg
NC_006570:1405178*1405178142352318346Francisella tularensis subsp. tularensis Schu 4, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_006274:4910465*4910465493271922255Bacillus cereus E33L, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_005957:4850659*4850659487309922441Bacillus thuringiensis serovar konkukian str. 97-27, complete2e-0661.9BLASTN svgBLASTP svg
NC_005945:4854951*4854951487414219192Bacillus anthracis str. Sterne, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_004722:5027762*5027762504643418673Bacillus cereus ATCC 14579, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_003997:4852332*4852332487482222491Bacillus anthracis str. Ames, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_003909:4831000*4831000485077119772Bacillus cereus ATCC 10987, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_007880:1079634*1079634110602826395Francisella tularensis subsp. holarctica, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_008245:1405000*1405000142332918330Francisella tularensis subsp. tularensis FSC 198, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_014335:4800500*4800500481810917610Bacillus cereus biovar anthracis str. CI chromosome, complete2e-0661.9BLASTN svgBLASTP svg
NC_012472:4867210*4867210489813230923Bacillus cereus 03BB102, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_011772:4994500*4994500501209917600Bacillus cereus G9842, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_010677:707881*70788173076722887Francisella tularensis subsp. mediasiatica FSC147, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_010184:4879552*4879552489927119720Bacillus weihenstephanensis KBAB4, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_008601:1404933*1404933142455519623Francisella tularensis subsp. novicida U112, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_008600:4868000*4868000488698318984Bacillus thuringiensis str. Al Hakam, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_008369:1083598*1083598110999126394Francisella tularensis subsp. holarctica OSU18, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_004557:558500*55850058274124242Clostridium tetani E88, complete genome9e-0660BLASTN svgBLASTP svg
NC_009089:37820003782000380409922100Clostridium difficile 630, complete genome9e-0660BLASTN svgBLASTP svg
NC_011653:1671910*1671910169097919070Thermosipho africanus TCF52B, complete genome9e-0660BLASTN svgBLASTP svg
NC_012225:47800478008109933300Brachyspira hyodysenteriae WA1, complete genome9e-0660BLASTN svgBLASTP svg
NC_014150:29940002994000301678522786Brachyspira murdochii DSM 12563 chromosome, complete genome9e-0660BLASTN svgBLASTP svg
NC_003364:14633171463317150009936783Pyrobaculum aerophilum str. IM2, complete genome9e-0660BLASTN svgBLASTP svg