Pre_GI: BLASTN Hits

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Query: NC_017179:2895571 Clostridium difficile BI1, complete genome

Start: 2895571, End: 2919356, Length: 23786

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_004722:5381208*5381208540929928092Bacillus cereus ATCC 14579, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_016012:879972*87997290262722656Candidatus Arthromitus sp. SFB-rat-Yit, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_016012:236012*23601227777541764Candidatus Arthromitus sp. SFB-rat-Yit, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_012563:17043451704345173190427560Clostridium botulinum A2 str. Kyoto, complete genome3e-43184BLASTN svgBLASTP svg
NC_010516:34660003466000348809922100Clostridium botulinum B1 str. Okra, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_013316:29680002968000299190223903Clostridium difficile R20291, complete genome08421BLASTN svgBLASTP svg
NC_021182:93000*9300014465551656Clostridium pasteurianum BC1, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_008262:20256992025699204408118383Clostridium perfringens SM101, complete genome1e-48202BLASTN svgBLASTP svg
NC_009749:1825453*1825453184563820186Francisella tularensis subsp. holarctica FTA, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_008369:1830442*1830442185176221321Francisella tularensis subsp. holarctica OSU18, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_007880:1830803*1830803185098820186Francisella tularensis subsp. holarctica, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_008601:168063*16806319287624814Francisella tularensis subsp. novicida U112, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_014483:48911004891100490915518056Paenibacillus polymyxa E681 chromosome, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_007168:2631535*2631535265430622772Staphylococcus haemolyticus JCSC1435, complete genome5e-1177.8BLASTN svgBLASTP svg