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Query: NC_017179:281069 Clostridium difficile BI1, complete genome

Start: 281069, End: 304479, Length: 23411

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_010723:10840001084000110630222303Clostridium botulinum E3 str. Alaska E43, complete genome5e-54220BLASTN svgBLASTP svg
NC_020291:12668851266885130737240488Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome7e-41176BLASTN svgBLASTP svg
NC_010674:11244311124431114553121101Clostridium botulinum B str. Eklund 17B, complete genome1e-39172BLASTN svgBLASTP svg
NC_008593:16314381631438165059619159Clostridium novyi NT, complete genome2e-38168BLASTN svgBLASTP svg
NC_003366:84200084200086047418475Clostridium perfringens str. 13, complete genome1e-36163BLASTN svgBLASTP svg
NC_008262:784878*78487882991045033Clostridium perfringens SM101, complete genome2e-34155BLASTN svgBLASTP svg
NC_021182:2059143*2059143208239023248Clostridium pasteurianum BC1, complete genome5e-23117BLASTN svgBLASTP svg
NC_010516:2877407*2877407289845321047Clostridium botulinum B1 str. Okra, complete genome8e-22113BLASTN svgBLASTP svg
NC_015958:81544281544283814622705Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genome3e-18101BLASTN svgBLASTP svg
NC_018607:135612*13561217740241791Brachyspira pilosicoli B2904 chromosome, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_010380:12465512465515098226328Streptococcus pneumoniae Hungary19A-6, complete genome5e-1487.7BLASTN svgBLASTP svg
NC_014614:35674635674640601049265Clostridium sticklandii, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_015565:27365002736500277293936440Desulfotomaculum carboxydivorans CO-1-SRB chromosome, complete2e-1075.8BLASTN svgBLASTP svg
NC_014328:93839393839395781019418Clostridium ljungdahlii ATCC 49587 chromosome, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_003030:15100001510000154543435435Clostridium acetobutylicum ATCC 824, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_008261:551513*55151357420222690Clostridium perfringens ATCC 13124, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_013961:2260250*2260250228983729588Erwinia amylovora, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_015578:18074281807428184533137904Treponema primitia ZAS-2 chromosome, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_010939:1633000*1633000166140328404Actinobacillus pleuropneumoniae serovar 7 str. AP76, complete7e-0763.9BLASTN svgBLASTP svg
NC_010674:36197223619722364030220581Clostridium botulinum B str. Eklund 17B, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_004193:78395878395880200618049Oceanobacillus iheyensis HTE831, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_004061:31500*315005549924000Buchnera aphidicola str. Sg (Schizaphis graminum), complete genome3e-0661.9BLASTN svgBLASTP svg
NC_004342:16489771648977166723918263Leptospira interrogans serovar Lai str. 56601 chromosome I,3e-0661.9BLASTN svgBLASTP svg
NC_005966:69689696899119521507Acinetobacter sp. ADP1, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_009848:31906193190619321885828240Bacillus pumilus SAFR-032, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_010001:42508284250828427265121824Clostridium phytofermentans ISDg, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_005823:25665882566588258537518788Leptospira interrogans serovar Copenhageni str. Fiocruz L1-1303e-0661.9BLASTN svgBLASTP svg
AP010958:25040722504072253559331522Escherichia coli O103:H2 str. 12009 DNA, complete genome3e-0661.9BLASTN svgBLASTP svg