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Query: NC_017179:2539031 Clostridium difficile BI1, complete genome

Start: 2539031, End: 2573204, Length: 34174

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_013316:26231992623199264226019062Clostridium difficile R20291, complete genome04879BLASTN svgBLASTP svg
NC_012563:14640001464000148609922100Clostridium botulinum A2 str. Kyoto, complete genome1e-49206BLASTN svgBLASTP svg
NC_010516:13820001382000140409922100Clostridium botulinum B1 str. Okra, complete genome1e-49206BLASTN svgBLASTP svg
NC_010520:14279811427981145070222722Clostridium botulinum A3 str. Loch Maree, complete genome3e-47198BLASTN svgBLASTP svg
NC_014614:1259236*1259236127792218687Clostridium sticklandii, complete genome4e-46194BLASTN svgBLASTP svg
NC_010520:3526883*3526883355123524353Clostridium botulinum A3 str. Loch Maree, complete genome4e-37165BLASTN svgBLASTP svg
NC_018604:78957578957581008920515Brachyspira pilosicoli WesB complete genome8e-29137BLASTN svgBLASTP svg
NC_018607:66269766269768184019144Brachyspira pilosicoli B2904 chromosome, complete genome8e-29137BLASTN svgBLASTP svg
NC_019908:12256901225690124895123262Brachyspira pilosicoli P43/6/78 chromosome, complete genome2e-26129BLASTN svgBLASTP svg
NC_014330:20261932026193204718920997Brachyspira pilosicoli 95/1000 chromosome, complete genome3e-25125BLASTN svgBLASTP svg
NC_014150:3085013*3085013310947924467Brachyspira murdochii DSM 12563 chromosome, complete genome2e-23119BLASTN svgBLASTP svg
NC_019978:21893942189394220827218879Halobacteroides halobius DSM 5150, complete genome8e-20107BLASTN svgBLASTP svg
NC_014328:30666283066628308784821221Clostridium ljungdahlii ATCC 49587 chromosome, complete genome2e-1799.6BLASTN svgBLASTP svg
NC_014328:2990790*2990790303209941310Clostridium ljungdahlii ATCC 49587 chromosome, complete genome2e-1489.7BLASTN svgBLASTP svg
NC_010718:49722249722251659019369Natranaerobius thermophilus JW/NM-WN-LF, complete genome1e-1283.8BLASTN svgBLASTP svg
NC_013192:107672*10767213303725366Leptotrichia buccalis DSM 1135, complete genome2e-1179.8BLASTN svgBLASTP svg
NC_003869:18126421812642183146018819Thermoanaerobacter tengcongensis MB4, complete genome2e-1179.8BLASTN svgBLASTP svg
NC_020291:40330004033000405659923600Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome3e-1075.8BLASTN svgBLASTP svg
NC_013316:89178289178291434722566Clostridium difficile R20291, complete genome3e-0765.9BLASTN svgBLASTP svg
NC_009089:96595996595998833722379Clostridium difficile 630, complete genome1e-0663.9BLASTN svgBLASTP svg