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Query: NC_017179:2513804 Clostridium difficile BI1, complete genome

Start: 2513804, End: 2536976, Length: 23173

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_013316:25856662585666260952923864Clostridium difficile R20291, complete genome05689BLASTN svgBLASTP svg
NC_015687:14786681478668150267124004Clostridium acetobutylicum DSM 1731 chromosome, complete genome8e-1693.7BLASTN svgBLASTP svg
NC_008555:2628858*2628858264800219145Listeria welshimeri serovar 6b str. SLCC5334, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_003212:2814737*2814737283390519169Listeria innocua Clip11262, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_003210:2721559*2721559274413822580Listeria monocytogenes EGD-e, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_020291:50931385093138512061727480Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome1e-1179.8BLASTN svgBLASTP svg
NC_015555:2259500*2259500230459945100Thermoanaerobacterium xylanolyticum LX-11 chromosome, complete1e-1179.8BLASTN svgBLASTP svg
NC_014328:303063*30306337786274800Clostridium ljungdahlii ATCC 49587 chromosome, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_010674:18229631822963184273319771Clostridium botulinum B str. Eklund 17B, complete genome5e-1177.8BLASTN svgBLASTP svg
NC_008262:784878*78487882991045033Clostridium perfringens SM101, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_010723:19671061967106199111924014Clostridium botulinum E3 str. Alaska E43, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_020410:37559783755978377491118934Bacillus amyloliquefaciens subsp. plantarum UCMB5036 complete7e-0763.9BLASTN svgBLASTP svg
NC_018664:12799501279950129986019911Clostridium acidurici 9a chromosome, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_009725:37639223763922378373119810Bacillus amyloliquefaciens FZB42, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_019970:2551607*2551607257838226776Thermoanaerobacterium thermosaccharolyticum M0795, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_013887:1462918*1462918148166818751Methanocaldococcus sp. FS406-22 chromosome, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_010718:2337209*2337209237318135973Natranaerobius thermophilus JW/NM-WN-LF, complete genome3e-0661.9BLASTN svgBLASTP svg