Pre_GI: BLASTN Hits

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Query: NC_017179:2067015 Clostridium difficile BI1, complete genome

Start: 2067015, End: 2090783, Length: 23769

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_003366:10917661091766111615524390Clostridium perfringens str. 13, complete genome0938BLASTN svgBLASTP svg
NC_008261:10485151048515107289224378Clostridium perfringens ATCC 13124, complete genome0930BLASTN svgBLASTP svg
NC_004557:2289135*2289135231328724153Clostridium tetani E88, complete genome2e-93351BLASTN svgBLASTP svg
NC_015275:44935004493500451163218133Clostridium lentocellum DSM 5427 chromosome, complete genome9e-59236BLASTN svgBLASTP svg
NC_013192:63111631119378730677Leptotrichia buccalis DSM 1135, complete genome1e-45192BLASTN svgBLASTP svg
NC_012563:23845002384500240296118462Clostridium botulinum A2 str. Kyoto, complete genome2e-44188BLASTN svgBLASTP svg
NC_014614:284005*28400531809934095Clostridium sticklandii, complete genome3e-43184BLASTN svgBLASTP svg
NC_009922:25560332556033258448628454Alkaliphilus oremlandii OhILAs, complete genome1e-39172BLASTN svgBLASTP svg
NC_004557:15530001553000157059917600Clostridium tetani E88, complete genome1e-39172BLASTN svgBLASTP svg
NC_013517:1055854*10558541161670105817Sebaldella termitidis ATCC 33386, complete genome2e-35159BLASTN svgBLASTP svg
NC_010723:19671061967106199111924014Clostridium botulinum E3 str. Alaska E43, complete genome6e-35157BLASTN svgBLASTP svg
NC_010674:18229631822963184273319771Clostridium botulinum B str. Eklund 17B, complete genome2e-32149BLASTN svgBLASTP svg
NC_010674:14965001496500152566029161Clostridium botulinum B str. Eklund 17B, complete genome4e-27131BLASTN svgBLASTP svg
NC_010723:14650971465097149459929503Clostridium botulinum E3 str. Alaska E43, complete genome9e-25123BLASTN svgBLASTP svg
NC_020291:795500*79550085457259073Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome1e-23119BLASTN svgBLASTP svg
NC_010001:17450891745089177589430806Clostridium phytofermentans ISDg, complete genome1e-23119BLASTN svgBLASTP svg
NC_009922:86826286826289020421943Alkaliphilus oremlandii OhILAs, complete genome5e-23117BLASTN svgBLASTP svg
NC_018664:3009166*3009166304846639301Clostridium acidurici 9a chromosome, complete genome2e-19105BLASTN svgBLASTP svg
NC_014328:12864071286407130824221836Clostridium ljungdahlii ATCC 49587 chromosome, complete genome3e-18101BLASTN svgBLASTP svg
NC_014328:43160084316008434476228755Clostridium ljungdahlii ATCC 49587 chromosome, complete genome3e-18101BLASTN svgBLASTP svg
NC_014019:35433893543389356611222724Bacillus megaterium QM B1551 chromosome, complete genome8e-1693.7BLASTN svgBLASTP svg
NC_014654:11131161113116113933826223Halanaerobium sp. 'sapolanicus' chromosome, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_014376:15866491586649160872922081Clostridium saccharolyticum WM1 chromosome, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_021182:10777211077721109639718677Clostridium pasteurianum BC1, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_014654:22774612277461230062123161Halanaerobium sp. 'sapolanicus' chromosome, complete genome2e-0765.9BLASTN svgBLASTP svg