Pre_GI: BLASTN Hits

Some Help

Query: NC_017179:1239991 Clostridium difficile BI1, complete genome

Start: 1239991, End: 1259172, Length: 19182

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia



Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_009848:1542978*1542978156391120934Bacillus pumilus SAFR-032, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_008599:1325155*1325155134694521791Campylobacter fetus subsp. fetus 82-40, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_003912:426676*42667645038423709Campylobacter jejuni RM1221, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_014802:392852*39285241656323712Campylobacter jejuni subsp. jejuni ICDCCJ07001 chromosome, complete2e-0661.9BLASTN svgBLASTP svg
NC_003030:3763054*3763054378965126598Clostridium acetobutylicum ATCC 824, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_003030:26309312630931265360822678Clostridium acetobutylicum ATCC 824, complete genome4e-91343BLASTN svgBLASTP svg
NC_015687:3766000*3766000379114625147Clostridium acetobutylicum DSM 1731 chromosome, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_015687:2632557*2632557266659934043Clostridium acetobutylicum DSM 1731 chromosome, complete genome4e-91343BLASTN svgBLASTP svg
NC_018664:1699618*1699618171859918982Clostridium acidurici 9a chromosome, complete genome5e-38167BLASTN svgBLASTP svg
NC_012563:2761570*2761570280230240733Clostridium botulinum A2 str. Kyoto, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_012563:4101000*4101000412265321654Clostridium botulinum A2 str. Kyoto, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_010520:2635750*2635750265654120792Clostridium botulinum A3 str. Loch Maree, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_010520:11460001146000116884922850Clostridium botulinum A3 str. Loch Maree, complete genome2e-77297BLASTN svgBLASTP svg
NC_010520:3938490*3938490397609937610Clostridium botulinum A3 str. Loch Maree, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_010674:11702641170264119243322170Clostridium botulinum B str. Eklund 17B, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_010674:37062937062939810727479Clostridium botulinum B str. Eklund 17B, complete genome6e-87329BLASTN svgBLASTP svg
NC_010516:3903867*3903867395059846732Clostridium botulinum B1 str. Okra, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_010516:2567911*2567911258780819898Clostridium botulinum B1 str. Okra, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_010723:1133163*1133163115110717945Clostridium botulinum E3 str. Alaska E43, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_010723:13792561379256140062221367Clostridium botulinum E3 str. Alaska E43, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_014393:49881274988127501003921913Clostridium cellulovorans 743B chromosome, complete genome2e-0971.9BLASTN svgBLASTP svg
NC_013316:1225797*1225797124983024034Clostridium difficile R20291, complete genome08217BLASTN svgBLASTP svg
NC_014328:4546390*4546390457009623707Clostridium ljungdahlii ATCC 49587 chromosome, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_008593:1797000*1797000182201325014Clostridium novyi NT, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_008593:37456*374566080623351Clostridium novyi NT, complete genome2e-1281.8BLASTN svgBLASTP svg
NC_021182:48824944882494490859926106Clostridium pasteurianum BC1, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_008262:227354*22735427081243459Clostridium perfringens SM101, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_003366:25548025548029721641737Clostridium perfringens str. 13, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_020291:12668851266885130737240488Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome2e-0661.9BLASTN svgBLASTP svg
NC_004557:81362*8136210417722816Clostridium tetani E88, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_009718:643200*64320068474241543Fervidobacterium nodosum Rt17-B1, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_014654:11131161113116113933826223Halanaerobium sp. 'sapolanicus' chromosome, complete genome9e-0660BLASTN svgBLASTP svg
NC_019978:1410041*1410041143133721297Halobacteroides halobius DSM 5150, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_005364:29250729250731273220226Mycoplasma mycoides subsp. mycoides SC str. PG1, complete genome9e-0660BLASTN svgBLASTP svg
NC_013517:2633574*2633574265613222559Sebaldella termitidis ATCC 33386, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_010730:1724443*1724443174211517673Sulfurihydrogenibium sp. YO3AOP1, complete genome3e-33151BLASTN svgBLASTP svg
NC_014964:1309845*1309845133261422770Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, complete6e-1073.8BLASTN svgBLASTP svg
NC_015958:1422319*1422319144310120783Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_011653:1616423*1616423164434727925Thermosipho africanus TCF52B, complete genome4e-0867.9BLASTN svgBLASTP svg