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Query: NC_017179:1133510 Clostridium difficile BI1, complete genome

Start: 1133510, End: 1152400, Length: 18891

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_012225:21989872198987222132922343Brachyspira hyodysenteriae WA1, complete genome4e-48200BLASTN svgBLASTP svg
NC_018604:2579000*2579000263363754638Brachyspira pilosicoli WesB complete genome3e-39170BLASTN svgBLASTP svg
NC_019908:2068631*2068631210767339043Brachyspira pilosicoli P43/6/78 chromosome, complete genome1e-38168BLASTN svgBLASTP svg
NC_018607:290500*29050033195841459Brachyspira pilosicoli B2904 chromosome, complete genome1e-38168BLASTN svgBLASTP svg
NC_014330:1113145*1113145114959936455Brachyspira pilosicoli 95/1000 chromosome, complete genome1e-38168BLASTN svgBLASTP svg
NC_010516:34660003466000348809922100Clostridium botulinum B1 str. Okra, complete genome2e-31145BLASTN svgBLASTP svg
NC_004557:25524182552418257431921902Clostridium tetani E88, complete genome2e-25125BLASTN svgBLASTP svg
NC_009089:10938321093832111768023849Clostridium difficile 630, complete genome3e-24121BLASTN svgBLASTP svg
NC_010674:37062937062939810727479Clostridium botulinum B str. Eklund 17B, complete genome3e-24121BLASTN svgBLASTP svg
NC_010723:37174137174139352221782Clostridium botulinum E3 str. Alaska E43, complete genome3e-24121BLASTN svgBLASTP svg
NC_020291:49100049100051106420065Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome3e-24121BLASTN svgBLASTP svg
NC_003366:24949072494907251858823682Clostridium perfringens str. 13, complete genome4e-23117BLASTN svgBLASTP svg
NC_008261:2708929*2708929273260323675Clostridium perfringens ATCC 13124, complete genome4e-23117BLASTN svgBLASTP svg
NC_008262:2379144*2379144239845819315Clostridium perfringens SM101, complete genome4e-23117BLASTN svgBLASTP svg
NC_010516:23740002374000239681422815Clostridium botulinum B1 str. Okra, complete genome4e-23117BLASTN svgBLASTP svg
NC_013316:1225797*1225797124983024034Clostridium difficile R20291, complete genome3e-21111BLASTN svgBLASTP svg
NC_014393:36509573650957366964218686Clostridium cellulovorans 743B chromosome, complete genome1e-20109BLASTN svgBLASTP svg
NC_008593:15131071513107153682423718Clostridium novyi NT, complete genome1e-20109BLASTN svgBLASTP svg
NC_008262:24980002498000252144223443Clostridium perfringens SM101, complete genome3e-18101BLASTN svgBLASTP svg
NC_021182:14735351473535149659923065Clostridium pasteurianum BC1, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_020291:22914182291418231430022883Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome4e-1797.6BLASTN svgBLASTP svg
NC_020291:684500*68450070271718218Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome2e-1591.7BLASTN svgBLASTP svg
NC_008593:22818962281896230590024005Clostridium novyi NT, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_003366:12878312878314709918317Clostridium perfringens str. 13, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_012563:24660002466000248852922530Clostridium botulinum A2 str. Kyoto, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_018664:1699618*1699618171859918982Clostridium acidurici 9a chromosome, complete genome9e-1279.8BLASTN svgBLASTP svg
NC_009089:96595996595998833722379Clostridium difficile 630, complete genome4e-1177.8BLASTN svgBLASTP svg
NC_004193:26921362692136271369521560Oceanobacillus iheyensis HTE831, complete genome4e-1177.8BLASTN svgBLASTP svg
NC_010723:13792561379256140062221367Clostridium botulinum E3 str. Alaska E43, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_010723:485874*48587450809922226Clostridium botulinum E3 str. Alaska E43, complete genome2e-0971.9BLASTN svgBLASTP svg
NC_013316:89178289178291434722566Clostridium difficile R20291, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_010674:13904731390473141116620694Clostridium botulinum B str. Eklund 17B, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_010718:1959517*1959517198298623470Natranaerobius thermophilus JW/NM-WN-LF, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_012563:37298173729817376659036774Clostridium botulinum A2 str. Kyoto, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_010516:35450173545017356809923083Clostridium botulinum B1 str. Okra, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_010382:1020516*1020516103923818723Lysinibacillus sphaericus C3-41, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_005957:43116794311679433450022822Bacillus thuringiensis serovar konkukian str. 97-27, complete2e-0661.9BLASTN svgBLASTP svg
NC_003454:20807052080705210460123897Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete2e-0661.9BLASTN svgBLASTP svg
NC_012225:25232622523262254758024319Brachyspira hyodysenteriae WA1, complete genome9e-0660BLASTN svgBLASTP svg