Pre_GI: BLASTP Hits

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Query: NC_017179:446564:462694 Clostridium difficile BI1, complete genome

Start: 462694, End: 462906, Length: 213

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009089:478328:478328478328479050723Clostridium difficile 630, complete genomeputative RNA pseudouridine synthase1e-24111
NC_010321:2256758:226000722600072260732726Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completepseudouridine synthase4e-1166.6
NC_015958:57957:718017180172526726Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomepseudouridine synthase Rsu4e-1166.6
NC_014964:2237979:224715022471502247875726Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completepseudouridine synthase4e-1166.6
NC_013921:36000:523525235253074723Thermoanaerobacter italicus Ab9 chromosome, complete genomeRNA-binding S4 domain protein1e-1065.5
NC_014209:81643:110590110590111312723Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,RNA-binding S4 domain protein1e-1065.5
NC_014410:51711:716907169072415726Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,RNA-binding S4 domain protein4e-1063.2
NC_010320:1805818:181440418144041815126723Thermoanaerobacter sp. X514 chromosome, complete genomepseudouridine synthase6e-1062.8
NC_014538:33718:501145011450836723Thermoanaerobacter sp. X513 chromosome, complete genomepseudouridine synthase6e-1062.8
NC_008262:2433979:246534424653442466063720Clostridium perfringens SM101, complete genome16S pseudouridylate synthase7e-1062.8
NC_019970:35985:575805758058305726Thermoanaerobacterium thermosaccharolyticum M0795, complete genomepseudouridine synthase family protein1e-0962
NC_015555:49842:707637076371485723Thermoanaerobacterium xylanolyticum LX-11 chromosome, completepseudouridine synthase Rsu4e-0960.1
NC_002745:1804000:180481518048151805510696Staphylococcus aureus subsp. aureus N315, complete genomehypothetical protein8e-0649.3
NC_002951:1848684:185145218514521852147696Staphylococcus aureus subsp. aureus COL, complete genomepseudouridine synthase, family 18e-0649.3
NC_009782:1881722:188412818841281884823696Staphylococcus aureus subsp. aureus Mu3, complete genomehypothetical protein8e-0649.3
NC_007795:1774725:177743717774371778132696Staphylococcus aureus subsp. aureus NCTC 8325, complete genomeribosomal small subunit pseudouridine synthase A, putative8e-0649.3
NC_002758:1880323:188272918827291883424696Staphylococcus aureus subsp. aureus Mu50, complete genomesimilar to 16S psudouridylate synthase8e-0649.3
NC_007793:1871165:187376318737631874458696Staphylococcus aureus subsp. aureus USA300, complete genomepseudouridine synthase, family 18e-0649.3
NC_002953:1819411:182195218219521822647696Staphylococcus aureus subsp. aureus MSSA476, complete genomeRNA pseudouridine synthase8e-0649.3
NC_003923:1841500:184261618426161843311696Staphylococcus aureus subsp. aureus MW2, complete genomehypothetical protein8e-0649.3
NC_010079:1871915:187451318745131875208696Staphylococcus aureus subsp. aureus USA300_TCH1516, completepseudouridylate synthase8e-0649.3
NC_009487:1925645:192793719279371928632696Staphylococcus aureus subsp. aureus JH9 chromosome, completepseudouridine synthase8e-0649.3
NC_017351:1869287:187134018713401872035696Staphylococcus aureus subsp. aureus 11819-97 chromosome, completepseudouridine synthase family protein8e-0649.3
NC_017347:1852500:185368718536871854382696Staphylococcus aureus subsp. aureus T0131 chromosome, completePseudouridine synthase8e-0649.3
NC_017343:1748620:175102617510261751721696Staphylococcus aureus subsp. aureus ECT-R 2, complete genomehypothetical protein8e-0649.3
NC_017341:1851972:185453318545331855228696Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,ribosomal small subunit pseudouridine synthase A8e-0649.3
NC_016912:1732354:173506617350661735761696Staphylococcus aureus subsp. aureus VC40 chromosome, completepseudouridine synthase family 1 protein8e-0649.3
NC_013450:1825010:182741618274161828111696Staphylococcus aureus subsp. aureus ED98, complete genomepseudouridine synthase family 1 protein8e-0649.3
NC_009641:1833000:183429318342931834988696Staphylococcus aureus subsp. aureus str. Newman chromosome,ribosomal small subunit pseudouridine synthase A8e-0649.3
NC_009632:1927372:192781119278111928506696Staphylococcus aureus subsp. aureus JH1 chromosome, completepseudouridine synthase8e-0649.3
NC_017337:1829840:183217718321771832872696Staphylococcus aureus subsp. aureus ED133 chromosome, completepseudouridine synthase, family 19e-0648.9
NC_017342:1462297:147786514778651478560696Staphylococcus aureus subsp. aureus TCH60 chromosome, completeribosomal small subunit pseudouridine synthase A9e-0648.9
NC_002952:1917999:192005319200531920748696Staphylococcus aureus subsp. aureus MRSA252, complete genomeRNA pseudouridine synthase9e-0648.9
NC_017338:1830790:183122918312291831924696Staphylococcus aureus subsp. aureus JKD6159 chromosome, completeribosomal small subunit pseudouridine synthase A9e-0648.9