Pre_GI: BLASTP Hits

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Query: NC_017179:446564:454678 Clostridium difficile BI1, complete genome

Start: 454678, End: 455805, Length: 1128

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:435599:4451154451154462421128Clostridium difficile CD196 chromosome, complete genomesubunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase0748
NC_010516:2374000:2384211238421123853381128Clostridium botulinum B1 str. Okra, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase, beta subunit7e-146517
NC_012563:2466000:2476322247632224774491128Clostridium botulinum A2 str. Kyoto, complete genome(R)-2-hydroxyglutaryl-CoA dehydratase, beta subunit1e-145516
NC_012658:2393427:2403727240372724048541128Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative (R)-2-hydroxyglutaryl-CoA dehydratase subunit beta2e-142505
NC_009698:2265475:2276164227616422772911128Clostridium botulinum A str. Hall chromosome, complete genomeR-2-hydroxyglutaryl-CoA dehydratase subunit beta2e-141502
NC_009697:2265409:2276098227609822772251128Clostridium botulinum A str. ATCC 19397 chromosome, completeR-2-hydroxyglutaryl-CoA dehydratase subunit beta2e-141502
NC_010516:3545017:3556372355637235574961125Clostridium botulinum B1 str. Okra, complete genomeR-phenyllactate dehydratase, C subunit2e-106386
NC_009699:3581376:3589096358909635902201125Clostridium botulinum F str. Langeland chromosome, complete genomeR-phenyllactate dehydratase subunit C1e-106386
NC_009698:3359766:3368560336856033696841125Clostridium botulinum A str. Hall chromosome, complete genomeR-phenyllactate dehydratase subunit C3e-106385
NC_009697:3463736:3471452347145234725761125Clostridium botulinum A str. ATCC 19397 chromosome, completeR-phenyllactate dehydratase subunit C3e-106385
NC_012563:3729817:3737520373752037386441125Clostridium botulinum A2 str. Kyoto, complete genomeR-phenyllactate dehydratase, C subunit7e-105380
NC_003454:822804:8351088351088362561149Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete(R)-2-hydroxyglutaryl-CoA dehydratase beta-subunit1e-70267
NC_011830:1190502:1191815119181511929541140Desulfitobacterium hafniense DCB-2, complete genome2-hydroxyglutaryl-CoA dehydratase D-component1e-28127
NC_009943:1043210:1043210104321010443311122Candidatus Desulfococcus oleovorans Hxd3, complete genome2-hydroxyglutaryl-CoA dehydratase D-component1e-20101
NC_013887:189400:2036122036122047541143Methanocaldococcus sp. FS406-22 chromosome, complete genome2-hydroxyglutaryl-CoA dehydratase D-component1e-20101
NC_010520:3526883:3531075353107535323341260Clostridium botulinum A3 str. Loch Maree, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase subunit2e-1583.6
NC_015562:1189111:1215101121510112162191119Methanotorris igneus Kol 5 chromosome, complete genome2-hydroxyglutaryl-CoA dehydratase D-component1e-1481.3
NC_009495:3832500:3870956387095638721041149Clostridium botulinum A str. ATCC 3502 chromosome, complete genome2-hydroxyacyl-CoA dehydratase subunit beta1e-1481.3
NC_010516:3903867:3942313394231339434611149Clostridium botulinum B1 str. Okra, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase subunit1e-1480.9
NC_009699:3940984:3979431397943139805791149Clostridium botulinum F str. Langeland chromosome, complete genomeR-2-hydroxyglutaryl-CoA dehydratase subunit2e-1480.1
NC_017297:3939328:3977127397712739782751149Clostridium botulinum F str. 230613 chromosome, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase subunit2e-1480.1
NC_011832:1148859:1177120117712011783011182Candidatus Methanosphaerula palustris E1-9c, complete genome2-hydroxyglutaryl-CoA dehydratase D-component2e-1480.1
NC_015589:2846000:2868226286822628693801155Desulfotomaculum ruminis DSM 2154 chromosome, complete genome2-hydroxyglutaryl-CoA dehydratase D-component1e-1377.8
NC_007519:64157:8277382773840531281Desulfovibrio alaskensis G20 chromosome, complete genome2-hydroxyglutaryl-CoA dehydratase subunit beta-like2e-1170.1
NC_012108:904260:9042609042609053931134Desulfobacterium autotrophicum HRM2, complete genomeputative (R)-2-hydroxyglutaryl-CoA dehydratase, beta subunit3e-1066.6
NC_010337:147664:1783951783951795701176Heliobacterium modesticaldum Ice1, complete genome2-hydroxyglutaryl-coa dehydratase subunit5e-1065.9