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Query: NC_017179:446564:453452 Clostridium difficile BI1, complete genome

Start: 453452, End: 454678, Length: 1227

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:435599:4438834438834451151233Clostridium difficile CD196 chromosome, complete genomesubunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase0850
NC_012563:2466000:2477449247744924786811233Clostridium botulinum A2 str. Kyoto, complete genome(R)-2-hydroxyglutaryl-CoA dehydratase, alpha subunit family0709
NC_012658:2393427:2404854240485424060861233Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative (R)-2-hydroxyglutaryl-CoA dehydratase subunit alpha0709
NC_010516:2374000:2385338238533823865701233Clostridium botulinum B1 str. Okra, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase, alpha subunit0709
NC_009698:2265475:2277291227729122785231233Clostridium botulinum A str. Hall chromosome, complete genomeR-2-hydroxyglutaryl-CoA dehydratase subunit alpha0707
NC_009697:2265409:2277225227722522784571233Clostridium botulinum A str. ATCC 19397 chromosome, completeR-2-hydroxyglutaryl-CoA dehydratase subunit alpha0707
NC_009699:3581376:3590222359022235914451224Clostridium botulinum F str. Langeland chromosome, complete genomeR-phenyllactate dehydratase subunit B8e-121434
NC_010516:3545017:3557498355749835587211224Clostridium botulinum B1 str. Okra, complete genomeR-phenyllactate dehydratase, B subunit8e-121434
NC_009697:3463736:3472578347257834738011224Clostridium botulinum A str. ATCC 19397 chromosome, completeR-phenyllactate dehydratase subunit B7e-121434
NC_009698:3359766:3369686336968633709091224Clostridium botulinum A str. Hall chromosome, complete genomeR-phenyllactate dehydratase subunit B7e-121434
NC_012563:3729817:3738646373864637398691224Clostridium botulinum A2 str. Kyoto, complete genomeR-phenyllactate dehydratase, B subunit1e-120433
NC_003454:822804:8337588337588350861329Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete(R)-2-hydroxyglutaryl-CoA dehydratase alpha-subunit3e-98358
NC_007503:1047577:1053400105340010546081209Carboxydothermus hydrogenoformans Z-2901, complete genomeputative (R)-2-hydroxyglutaryl-CoA dehydratase, alpha subunit9e-1581.6
NC_012563:2466000:2481921248192124831921272Clostridium botulinum A2 str. Kyoto, complete genome2-hydroxyglutaryl-CoA dehydratase, D-component2e-0964.3
NC_012658:2393427:2409477240947724107481272Clostridium botulinum Ba4 str. 657 chromosome, complete genome2-hydroxyglutaryl-CoA dehydratase subunit D2e-0963.5
NC_010516:2374000:2389816238981623910871272Clostridium botulinum B1 str. Okra, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase subunit1e-0861.2