Pre_GI: BLASTP Hits

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Query: NC_017179:446564:452637 Clostridium difficile BI1, complete genome

Start: 452637, End: 453437, Length: 801

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:435599:443065443065443874810Clostridium difficile CD196 chromosome, complete genomeactivator of 2-hydroxyisocaproyl-CoA dehydratase1e-144511
NC_012563:2466000:246994924699492470722774Clostridium botulinum A2 str. Kyoto, complete genome2-hydroxyglutaryl-CoA dehydratase component A2e-98358
NC_012658:2393427:239804723980472398820774Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative CoA-substrate-specific enzyme activase8e-98356
NC_009697:2265409:227002622700262270799774Clostridium botulinum A str. ATCC 19397 chromosome, complete2-hydroxyglutaryl-CoA dehydratase subunit A2e-97355
NC_009698:2265475:227009222700922270865774Clostridium botulinum A str. Hall chromosome, complete genome2-hydroxyglutaryl-CoA dehydratase2e-97355
NC_010516:2374000:237800923780092378782774Clostridium botulinum B1 str. Okra, complete genome2-hydroxyglutaryl-CoA dehydratase component A1e-97355
NC_012563:3729817:373987437398743740668795Clostridium botulinum A2 str. Kyoto, complete genomeR-phenyllactate dehydratase activator3e-77288
NC_009699:3581376:359145035914503592244795Clostridium botulinum F str. Langeland chromosome, complete genomeR-phenyllactate dehydratase activator4e-77288
NC_010516:3545017:355872635587263559520795Clostridium botulinum B1 str. Okra, complete genomeR-phenyllactate dehydratase activator4e-77288
NC_009697:3463736:347380634738063474600795Clostridium botulinum A str. ATCC 19397 chromosome, completeR-phenyllactate dehydratase activator4e-77287
NC_009698:3359766:337091433709143371708795Clostridium botulinum A str. Hall chromosome, complete genomeR-phenyllactate dehydratase activator4e-77287
NC_003454:822804:832898832898833695798Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeActivator of (R)-2-hydroxyglutaryl-CoA dehydratase9e-73273
NC_011832:1148859:117832011783201179126807Candidatus Methanosphaerula palustris E1-9c, complete genomeCoA-substrate-specific enzyme activase2e-61235
NC_007503:1047577:1054611105461110562631653Carboxydothermus hydrogenoformans Z-2901, complete genomeputative CoA dehydratase subunit/(R)-2-hydroxyglutaryl-CoA dehydratase activator7e-56217
NC_010516:2374000:2391090239109023927841695Clostridium botulinum B1 str. Okra, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase subunit/putative R-2-hydroxyglutaryl-CoA dehydratase activase2e-54212
NC_012563:2466000:2483195248319524848861692Clostridium botulinum A2 str. Kyoto, complete genomebenzoyl-CoA reductase, subunit A3e-54211
NC_009697:2265409:2283125228312522848191695Clostridium botulinum A str. ATCC 19397 chromosome, completeR-2-hydroxyglutaryl-CoA dehydratase subunit/ R-2-hydroxyglutaryl-CoA dehydratase activase3e-54211
NC_012658:2393427:2410751241075124124421692Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative CoA-substrate-specific enzyme activase4e-53208
NC_009943:1043210:104577010457701046591822Candidatus Desulfococcus oleovorans Hxd3, complete genomeputative CoA-substrate-specific enzyme activase3e-52205
NC_014828:2038692:208228120822812083090810Ethanoligenens harbinense YUAN-3 chromosome, complete genomeCoA-substrate-specific enzyme activase2e-48192
NC_015589:2846000:286744428674442868220777Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeCoA-substrate-specific enzyme activase4e-47188
NC_007519:64157:819938199382772780Desulfovibrio alaskensis G20 chromosome, complete genomeCoA enzyme activase1e-43176
NC_010520:3526883:352971535297153530473759Clostridium botulinum A3 str. Loch Maree, complete genomeputative CoA-substrate-specific enzyme activase8e-43174
NC_013887:189400:192714192714193445732Methanocaldococcus sp. FS406-22 chromosome, complete genomeCoA-substrate-specific enzyme activase4e-41168
NC_010337:147664:177486177486178340855Heliobacterium modesticaldum Ice1, complete genomeactivator of (r)-2-hydroxyglutaryl-coa dehydratase domain protein4e-39161
NC_015562:1189111:121368012136801214414735Methanotorris igneus Kol 5 chromosome, complete genomeCoA-substrate-specific enzyme activase6e-39161
NC_019908:2401577:2401577240157724026471071Brachyspira pilosicoli P43/6/78 chromosome, complete genomeCoA-substrate-specific enzyme activase2e-33142
NC_014314:576465:604657604657605466810Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, completeCoA-substrate-specific enzyme activase5e-33141
NC_016627:3815690:383284638328463833625780Clostridium clariflavum DSM 19732 chromosome, complete genomeCoA-substrate-specific enzyme activase, putative1e-32140
NC_018515:4442500:444366244436624444450789Desulfosporosinus meridiei DSM 13257 chromosome, complete genomeCoA-substrate-specific enzyme activase2e-31136
NC_016584:1436710:145659314565931457555963Desulfosporosinus orientis DSM 765 chromosome, complete genomeCoA-substrate-specific enzyme activase2e-31135
NC_009012:3653111:366096036609603661730771Clostridium thermocellum ATCC 27405, complete genomeputative CoA-substrate-specific enzyme activase7e-31134
NC_018876:1551155:1551155155115515523961242Methanolobus psychrophilus R15 chromosome, complete genomeBadF/BadG/BcrA/BcrD ATPase3e-29129
NC_011830:633195:6391766391766402791104Desulfitobacterium hafniense DCB-2, complete genomeCoA-substrate-specific enzyme activase7e-29127
NC_009464:3058665:3079639307963930808951257Uncultured methanogenic archaeon RC-I, complete genomeputative 2-hydroxyglutaryl-CoA dehydratase activator, component C (archerase)9e-29127
NC_015574:1676798:1682748168274816839831236Methanobacterium sp. SWAN-1 chromosome, complete genomemethanogenesis marker protein 151e-28127
NC_009483:1779601:1791041179104117941513111Geobacter uraniireducens Rf4 chromosome, complete genomeputative CoA-substrate-specific enzyme activase2e-28126
NC_014377:1227850:122938612293861230357972Thermosediminibacter oceani DSM 16646 chromosome, complete genomeCoA-substrate-specific enzyme activase2e-28126
NC_009943:1043210:104658810465881047358771Candidatus Desulfococcus oleovorans Hxd3, complete genomeputative CoA-substrate-specific enzyme activase4e-28125
NC_014253:1818000:1828187182818718294431257Methanohalobium evestigatum Z-7303 chromosome, complete genomemethanogenesis marker protein 155e-28124
NC_021182:4088000:410867741086774109630954Clostridium pasteurianum BC1, complete genomeCoA-substrate-specific enzyme activase, putative9e-28124
NC_020134:1243122:1240063124006312431493087Clostridium stercorarium subsp. stercorarium DSM 8532, completeCoA-substrate-specific enzyme activase2e-27123
NC_010718:128423:128423128423129397975Natranaerobius thermophilus JW/NM-WN-LF, complete genomeCoA-substrate-specific enzyme activase5e-27121
NC_013887:90929:115352115352116029678Methanocaldococcus sp. FS406-22 chromosome, complete genomeCoA-substrate-specific enzyme activase8e-26117
NC_010814:3048441:3088379308837930908232445Geobacter lovleyi SZ, complete genome8e-26117
NC_010516:3466000:347106934710693472043975Clostridium botulinum B1 str. Okra, complete genomeputative CoA-substrate-specific enzyme activase2e-25115
NC_009698:3275839:327583932758393276813975Clostridium botulinum A str. Hall chromosome, complete genomeCoA-substrate-specific enzyme activase2e-25115
NC_015578:1430112:1430112143011214345364425Treponema primitia ZAS-2 chromosome, complete genomeCoA enzyme activase9e-25114
NC_021184:569653:5696535696535739394287Desulfotomaculum gibsoniae DSM 7213, complete genomehypothetical protein1e-24114
NC_015425:2528549:256470925647092565647939Clostridium botulinum BKT015925 chromosome, complete genomeputative CoA-substrate-specific enzyme activase2e-24112
NC_009922:2323083:2344275234427523485614287Alkaliphilus oremlandii OhILAs, complete genomeputative CoA-substrate-specific enzyme activase2e-24112
NC_017098:1542284:1577543157754315820184476Spirochaeta africana DSM 8902 chromosome, complete genomeactivator of 2-hydroxyglutaryl-CoA dehydratase3e-24112
NC_007681:1157402:1173252117325211745051254Methanosphaera stadtmanae DSM 3091, complete genomepredicted activator of 2-hydroxyglutaryl-CoA dehydratase4e-24111
NC_013410:3192836:3192836319283631972874452Fibrobacter succinogenes subsp. succinogenes S85 chromosome,CoA-substrate-specific enzyme activase6e-24111
NC_015216:652266:6617006617006629321233Methanobacterium sp. AL-21 chromosome, complete genomemethanogenesis marker protein 159e-24110
NC_017217:1499832:1520045152004515247634719Bifidobacterium animalis subsp. lactis V9 chromosome, completehypothetical protein1e-22107
NC_012814:1494331:1514758151475815194764719Bifidobacterium animalis subsp. lactis Bl-04, complete genomehypothetical protein1e-22107
NC_012815:1494263:1514476151447615191944719Bifidobacterium animalis subsp. lactis DSM 10140, complete genomehypothetical protein1e-22107
NC_011835:625472:6456876456876503544668Bifidobacterium animalis subsp. lactis AD011 chromosome, completeactivator of 2-hydroxyglutaryl-CoA dehydratase1e-22107
NC_017216:1494190:1514403151440315190794677Bifidobacterium animalis subsp. lactis BLC1, complete genomeputative CoA-substrate-specific enzyme activase1e-22107
NC_017215:1499179:1519392151939215241524761Bifidobacterium animalis subsp. lactis CNCM I-2494 chromosome,Activator of (R)-2-hydroxyglutaryl-CoA dehydratase1e-22107
NC_017214:191791:2120042120042167644761Bifidobacterium animalis subsp. lactis BB-12 chromosome, completeActivator of (R)-2-hydroxyglutaryl-CoA dehydratase1e-22107
NC_009012:1595498:1613874161387416181754302Clostridium thermocellum ATCC 27405, complete genomeputative CoA-substrate-specific enzyme activase1e-22106
NC_020291:1535402:1557937155793715621694233Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative CoA-substrate-specific enzyme activase2e-22105
NC_015275:2712991:2712991271299127172114221Clostridium lentocellum DSM 5427 chromosome, complete genomeCoA-substrate-specific enzyme activase9e-22103
NC_014484:1690272:1690272169027216947054434Spirochaeta thermophila DSM 6192 chromosome, complete genomehypothetical protein1e-20100
NC_013171:342714:3533263533263576004275Anaerococcus prevotii DSM 20548, complete genomeCoA-substrate-specific enzyme activase2e-2099.8
NC_015732:2762424:2777720277772027823304611Spirochaeta caldaria DSM 7334 chromosome, complete genomeCoA-substrate-specific enzyme activase7e-2097.8
NC_010003:1746319:1755877175587717603404464Petrotoga mobilis SJ95, complete genomeCoA-substrate-specific enzyme activase3e-1995.9
NC_011145:4365730:4365730436573043699984269Anaeromyxobacter sp. K, complete genomeCoA-substrate-specific enzyme activase3e-1995.9
NC_016627:3205333:3228073322807332323774305Clostridium clariflavum DSM 19732 chromosome, complete genomehypothetical protein3e-1995.5
NC_014926:608894:6294446294446326473204Thermovibrio ammonificans HB-1 chromosome, complete genomeCoA-substrate-specific enzyme activase5e-1685.1