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Query: NC_017179:446564:448212 Clostridium difficile BI1, complete genome

Start: 448212, End: 448808, Length: 597

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:435599:438649438649439245597Clostridium difficile CD196 chromosome, complete genomeradical SAM protein3e-112403
NC_009089:428075:463846463846464442597Clostridium difficile 630, complete genomeRadical SAM-superfamily protein4e-103373
NC_015873:2260048:227489422748942275556663Megasphaera elsdenii DSM 20460, complete genomeradical SAM domain protein9e-45179
NC_016894:77853:804098040981002594Acetobacterium woodii DSM 1030 chromosome, complete genomehypothetical protein4e-40164
NC_013410:1651000:167608416760841676743660Fibrobacter succinogenes subsp. succinogenes S85 chromosome,radical SAM protein4e-40164
NC_014624:828943:846126846126846743618Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein2e-37155
NC_007907:5404608:542126254212625421645384Desulfitobacterium hafniense Y51, complete genomehypothetical protein5e-24110