Pre_GI: BLASTP Hits

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Query: NC_017179:3984000:4004689 Clostridium difficile BI1, complete genome

Start: 4004689, End: 4005324, Length: 636

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:3978495:399666939966693997304636Clostridium difficile CD196 chromosome, complete genomehypothetical protein1e-121434
NC_009089:4177117:419913441991344199721588Clostridium difficile 630, complete genomehypothetical protein1e-110399
NC_005791:837505:842609842609843238630Methanococcus maripaludis S2, complete genomehypothetical protein7e-64243
NC_015847:909938:915014915014915643630Methanococcus maripaludis XI chromosome, complete genomehypothetical protein8e-64243
NC_009135:620312:631416631416632045630Methanococcus maripaludis C5, complete genomehypothetical protein9e-64243
NC_009975:1682000:169635916963591696988630Methanococcus maripaludis C6, complete genomeProtein of unknown function DUF18473e-63241
NC_007498:3540945:355720635572063557883678Pelobacter carbinolicus DSM 2380, complete genomeconserved uncharacterized metal-binding protein4e-47187
NC_015562:899030:920971920971921546576Methanotorris igneus Kol 5 chromosome, complete genomehypothetical protein1e-41169
NC_007907:3872805:387588538758853876520636Desulfitobacterium hafniense Y51, complete genomehypothetical protein4e-40164
NC_000909:404961:406279406279406860582Methanocaldococcus jannaschii DSM 2661, complete genomehypothetical protein4e-40164
NC_013887:1668913:166990216699021670483582Methanocaldococcus sp. FS406-22 chromosome, complete genomeProtein of unknown function DUF18471e-38159
NC_013156:633475:652792652792653361570Methanocaldococcus fervens AG86, complete genomeProtein of unknown function DUF18477e-37153
NC_017078:179848:201910201910202515606Selenomonas ruminantium subsp. lactilytica TAM6421 plasmid pSRC1,hypothetical protein1e-32139
NC_016584:85543:102038102038102631594Desulfosporosinus orientis DSM 765 chromosome, complete genomemetal-binding protein3e-32138