Pre_GI: BLASTP Hits

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Query: NC_017179:3984000:3988073 Clostridium difficile BI1, complete genome

Start: 3988073, End: 3988930, Length: 858

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:3978495:398005339800533980910858Clostridium difficile CD196 chromosome, complete genomeMerR family transcriptional regulator1e-130466
NC_009089:4177117:418251841825184183375858Clostridium difficile 630, complete genomeMerR-family transcriptional regulator4e-130464
NC_020418:14965:164191641917276858Morganella morganii subsp. morganii KT, complete genomeTranscriptional regulator, MerR family4e-94344
NC_009699:1122000:114293611429361143757822Clostridium botulinum F str. Langeland chromosome, complete genomeMerR family transcriptional regulator8e-24110
NC_017195:2498113:254309625430962543944849Bacillus subtilis subsp. subtilis str. RO-NN-1 chromosome, completeBmrR3e-23108
NC_016047:2658000:268882426888242689669846Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completeBmrR protein8e-23107
NC_006270:2657726:267236126723612673206846Bacillus licheniformis ATCC 14580, complete genometranscriptional regulator3e-22105
NC_006322:2658587:267322126732212674066846Bacillus licheniformis ATCC 14580, complete genomeBmrR3e-22105
UCMB5137:2054735:207424220742422075075834Bacillus atrophaeus UCMB-5137BmrR protein9e-22104
NC_016584:4325964:432874343287434329555813Desulfosporosinus orientis DSM 765 chromosome, complete genometranscriptional regulator1e-1790.9
NC_010723:1379256:138162413816241382097474Clostridium botulinum E3 str. Alaska E43, complete genomeMerR-family transcriptional regulator7e-1788.2
UCMB5137:3660165:367585036758503676662813Bacillus atrophaeus UCMB-5137putative transcriptional regulator of efflux transporter2e-1583.6
NC_016633:14000:202342023420998765Sphaerochaeta pleomorpha str. Grapes chromosome, complete genomeputative transcriptional regulator3e-1375.9
NC_013316:4095905:412571441257144126526813Clostridium difficile R20291, complete genomeMerR-family transcriptional regulator4e-1375.5
NC_013315:4015119:404492840449284045740813Clostridium difficile CD196 chromosome, complete genomeMerR family transcriptional regulator4e-1375.5
NC_017179:4023139:405294840529484053760813Clostridium difficile BI1, complete genomeMerR family transcriptional regulator4e-1375.5
NC_014221:792363:806617806617807441825Truepera radiovictrix DSM 17093 chromosome, complete genometranscriptional regulator, MerR family8e-1271.2
NC_010001:109893:130233130233131072840Clostridium phytofermentans ISDg, complete genometranscriptional regulator, MerR family2e-1170.1
NC_016047:2658000:268162426816242682445822Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completemultidrug-efflux transporter 2 regulator7e-1168.2
NC_013406:3672857:371383337138333714651819Paenibacillus sp. Y412MC10 chromosome, complete genomeMerR family transcriptional regulator8e-1167.8
NC_000964:2702376:271526127152612716082822Bacillus subtilis subsp. subtilis str. 168, complete genometranscriptional regulator1e-1067.4
CP002207:1358597:138278313827831383610828Bacillus atrophaeus 1942, complete genometranscriptional regulator1e-1067.4
NC_014639:1358597:138278313827831383610828Bacillus atrophaeus 1942 chromosome, complete genometranscriptional regulator1e-1067.4
NC_014633:655693:656410656410657219810Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequencetranscriptional regulator, MerR family1e-1067.4
NC_016584:2244966:227049422704942271303810Desulfosporosinus orientis DSM 765 chromosome, complete genometranscriptional regulator2e-1066.6
NC_017195:2498113:252272125227212523542822Bacillus subtilis subsp. subtilis str. RO-NN-1 chromosome, completemultidrug-efflux transporter 2 regulator2e-1066.2
NC_014976:684000:699900699900700721822Bacillus subtilis BSn5 chromosome, complete genometranscriptional regulator2e-1066.2
NC_019896:1483073:150976115097611510582822Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completeMultidrug-efflux transporter 2 regulator3e-1066.2
NC_020244:2509000:253068625306862531507822Bacillus subtilis XF-1, complete genometranscriptional regulator3e-1066.2
NC_009077:5286275:528973352897335290563831Mycobacterium sp. JLS, complete genomeputative transcriptional regulator, MerR family4e-1065.5
UCMB5137:1396603:141244914124491413276828Bacillus atrophaeus UCMB-5137transcriptional regulator6e-1065.1
NC_016641:3058571:307297930729793073785807Paenibacillus terrae HPL-003 chromosome, complete genomeMerR family transcriptional regulator1e-0963.9
NC_014479:2505823:252323425232342524088855Bacillus subtilis subsp. spizizenii str. W23 chromosome, completetranscriptional regulator3e-0962.8
NC_015589:38418:474844748448287804Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeregulatory protein MerR3e-0962.4
NC_013757:2630000:263326726332672634079813Geodermatophilus obscurus DSM 43160, complete genometranscriptional regulator, MerR family7e-0961.2
NC_009495:2244774:226237822623782263208831Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeMerR family transcriptional regulator2e-0859.7
NC_009697:2173000:219102021910202191850831Clostridium botulinum A str. ATCC 19397 chromosome, completeMerR family transcriptional regulator2e-0859.7
NC_009698:2171151:219123921912392192069831Clostridium botulinum A str. Hall chromosome, complete genomeMerR family transcriptional regulator2e-0859.7
NC_015957:2781740:2788861278886127899131053Streptomyces violaceusniger Tu 4113 chromosome, complete genomeMerR family transcriptional regulator3e-0858.9
NC_009338:955195:975815975815976687873Mycobacterium gilvum PYR-GCK chromosome, complete genomeMerR family transcriptional regulator7e-0858.2
NC_016582:4934854:494056949405694941468900Streptomyces bingchenggensis BCW-1 chromosome, complete genomeputative transcriptional regulator, MerR family protein7e-0858.2
NC_016048:4163225:419321241932124194036825Oscillibacter valericigenes Sjm18-20, complete genomeputative MerR family transcriptional regulator1e-0757.4
NC_010571:5650806:565551656555165655920405Opitutus terrae PB90-1, complete genometranscriptional regulator, MerR family1e-0757.4
NC_004557:1553000:156846115684611569303843Clostridium tetani E88, complete genometranscriptional regulatory protein1e-0757.4
NC_016048:797762:800661800661801476816Oscillibacter valericigenes Sjm18-20, complete genomeputative MerR family transcriptional regulator2e-0756.6
NC_015977:2920500:293618029361802936914735Roseburia hominis A2-183 chromosome, complete genomehypothetical protein3e-0756.2
NC_015660:3518931:355621435562143556987774Geobacillus thermoglucosidasius C56-YS93 chromosome, completeMerR family transcriptional regulator3e-0756.2
NC_010571:5650806:5651894565189456574565563Opitutus terrae PB90-1, complete genome3e-0755.8
NC_010001:1745089:175040017504001751233834Clostridium phytofermentans ISDg, complete genometranscriptional regulator, MerR family3e-0755.8
NC_019896:17873:404364043641140705Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completetranscriptional regulator1e-0653.5
NC_004193:375416:406314406314407078765Oceanobacillus iheyensis HTE831, complete genometranscriptional activator of multidrug-efflux transporters2e-0653.5
NC_014624:2569604:258018525801852580961777Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein2e-0653.1
NC_015690:1818333:189300718930071893480474Paenibacillus mucilaginosus KNP414 chromosome, complete genomeMerR family transcriptional regulator5e-0652
NC_016935:2347691:242275624227562423229474Paenibacillus mucilaginosus 3016 chromosome, complete genomeMerR family transcriptional regulator5e-0652
NC_017208:5124333:513829351382935139048756Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeMerR family transcriptional regulator4e-0652
NC_010723:1465097:146844114684411469277837Clostridium botulinum E3 str. Alaska E43, complete genometranscriptional regulatory protein5e-0651.6
NC_010674:1496500:149822114982211499057837Clostridium botulinum B str. Eklund 17B, complete genometranscriptional regulatory protein6e-0651.6
NC_016627:3158353:317921431792143180050837Clostridium clariflavum DSM 19732 chromosome, complete genomeputative transcriptional regulator7e-0651.6
NC_004722:5057825:506977350697735070537765Bacillus cereus ATCC 14579, complete genomeTranscriptional regulator, MerR family8e-0651.2