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Query: NC_017179:3621306:3639899 Clostridium difficile BI1, complete genome

Start: 3639899, End: 3640144, Length: 246

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:3613288:363188136318813632126246Clostridium difficile CD196 chromosome, complete genomehypothetical protein3e-40163
NC_013315:1230214:124705112470511247299249Clostridium difficile CD196 chromosome, complete genomehypothetical protein5e-1476.3
NC_013316:1225797:124466812446681244916249Clostridium difficile R20291, complete genomehypothetical protein5e-1476.3
NC_017179:1239991:125683212568321257077246Clostridium difficile BI1, complete genomehypothetical protein6e-1476.3
NC_009615:871982:891017891017891274258Parabacteroides distasonis ATCC 8503 chromosome, complete genomehypothetical protein7e-1269.3
NC_015977:2718437:274589427458942746154261Roseburia hominis A2-183 chromosome, complete genomehypothetical protein2e-1168.2
NC_015578:465814:465814465814466071258Treponema primitia ZAS-2 chromosome, complete genomehypothetical protein3e-1063.5
NC_017068:2604876:263058926305892630852264Selenomonas ruminantium subsp. lactilytica TAM6421, completehypothetical protein1e-0961.6
NC_016803:593484:609286609286609576291Desulfovibrio desulfuricans ND132 chromosome, complete genomehypothetical protein8e-0959.3
NC_015873:790961:807032807032807289258Megasphaera elsdenii DSM 20460, complete genomehypothetical protein7e-0855.8
NC_015385:2135456:214997121499712150231261Treponema succinifaciens DSM 2489 chromosome, complete genomehypothetical protein1e-0755.5