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Query: NC_017179:3621306:3629960 Clostridium difficile BI1, complete genome

Start: 3629960, End: 3630244, Length: 285

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:3613288:362194236219423622226285Clostridium difficile CD196 chromosome, complete genomehypothetical protein7e-48188
NC_009089:3782000:379345837934583793742285Clostridium difficile 630, complete genomehypothetical protein7e-48188
NC_017297:2635892:264468426446842644959276Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein3e-1787
NC_009699:2635745:264453726445372644812276Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein3e-1787
NC_010516:2567911:258406825840682584343276Clostridium botulinum B1 str. Okra, complete genomehypothetical protein3e-1787
NC_012563:2761570:277036527703652770640276Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein3e-1787
NC_014614:2333890:234223223422322342492261Clostridium sticklandii, complete genomehypothetical protein5e-1786.3
NC_012563:2761570:278856327885632788838276Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein8e-1785.9
NC_012658:2641446:265408226540822654357276Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein9e-1785.5
NC_017297:2635892:266286826628682663143276Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein1e-1685.1
NC_009699:2654672:266271826627182662993276Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-1685.1
NC_009698:2450606:245865224586522458927276Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein1e-1685.1
NC_009697:2478261:248630724863072486582276Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein1e-1685.1
NC_009495:2606238:261419426141942614469276Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein1e-1685.1
NC_010520:2668702:267673526767352677010276Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein1e-1685.1
NC_010516:2594159:260223926022392602514276Clostridium botulinum B1 str. Okra, complete genomehypothetical protein1e-1685.1
NC_012658:2641446:266962526696252669900276Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein2e-1684.3