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Query: NC_017179:3621306:3624046 Clostridium difficile BI1, complete genome

Start: 3624046, End: 3624681, Length: 636

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:3613288:361602836160283616663636Clostridium difficile CD196 chromosome, complete genomesingle-stranded DNA-binding protein1e-117422
NC_009089:3782000:378754437875443788179636Clostridium difficile 630, complete genomesingle-stranded DNA binding protein1e-117422
NC_012563:3580000:360125636012563601957702Clostridium botulinum A2 str. Kyoto, complete genomesingle-strand binding domain protein2e-67255
NC_017294:1096000:111126511112651111936672Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomesingle-stranded DNA-binding protein9e-67253
NC_015913:1117500:113292511329251133581657Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomesingle-stranded DNA-binding protein1e-66252
NC_016012:1010405:102662810266281027284657Candidatus Arthromitus sp. SFB-rat-Yit, complete genomesingle-stranded DNA-binding protein4e-66250
NC_011837:3814000:388050838805083880948441Clostridium kluyveri NBRC 12016, complete genomehypothetical protein1e-0756.6
NC_009706:3882500:394900539490053949445441Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein1e-0756.6
NC_010674:2856997:286149828614982861920423Clostridium botulinum B str. Eklund 17B, complete genomesingle-strand binding protein5e-0754.7
NC_013766:679906:691505691505691984480Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein1e-0653.1
NC_009698:3706154:374374837437483744194447Clostridium botulinum A str. Hall chromosome, complete genomesingle-strand binding protein3e-0652
NC_003212:2413824:243106524310652431547483Listeria innocua Clip11262, complete genomehypothetical protein3e-0651.6
NC_009437:1481064:150397115039711504453483Caldicellulosiruptor saccharolyticus DSM 8903, complete genomesingle-strand binding protein5e-0651.2
NC_015949:1957185:196061519606151961103489Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomesingle-strand binding protein7e-0650.8
NC_009328:3504454:353459835345983535092495Geobacillus thermodenitrificans NG80-2 chromosome, complete genomessDNA-binding protein7e-0650.4
NC_013406:7092510:709787870978787098372495Paenibacillus sp. Y412MC10 chromosome, complete genomesingle-strand-binding protein9e-0650.4