Pre_GI: BLASTP Hits

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Query: NC_017179:3540739:3543625 Clostridium difficile BI1, complete genome

Start: 3543625, End: 3544971, Length: 1347

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:3532721:3535607353560735369531347Clostridium difficile CD196 chromosome, complete genomeRNA polymerase sigma-54 factor0831
NC_015519:2045935:2061532206153220629291398Tepidanaerobacter sp. Re1 chromosome, complete genomeRNA polymerase sigma 54 subunit RpoN9e-83307
NC_013216:4097056:4113068411306841144861419Desulfotomaculum acetoxidans DSM 771, complete genomeRNA polymerase, sigma 54 subunit, RpoN5e-81301
NC_014614:757381:7587047587047597591056Clostridium sticklandii, complete genomeSigL3e-80299
NC_020291:5641444:5654139565413956555271389Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative RNA polymerase sigma-54 factor RpoN1e-77291
NC_010814:2275199:2313912231391223153601449Geobacter lovleyi SZ, complete genomeRNA polymerase, sigma 54 subunit, RpoN2e-75283
NC_014328:4249032:4263165426316542645321368Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative RNA polymerase sigma-54 factor5e-73275
NC_009697:256354:2574082574082587811374Clostridium botulinum A str. ATCC 19397 chromosome, completeRNA polymerase factor sigma-542e-72273
NC_014758:1489761:1494835149483514962291395Calditerrivibrio nitroreducens DSM 19672 chromosome, completeRNA polymerase, sigma 54 subunit, rpon1e-71271
NC_015425:604842:6048426048426062181377Clostridium botulinum BKT015925 chromosome, complete genomeRNA polymerase sigma-54 factor4e-71269
NC_014844:1634985:1655818165581816572241407Desulfovibrio aespoeensis Aspo-2 chromosome, complete genomeRNA polymerase sigma-54 factor, RpoN2e-70267
NC_004557:363628:3649443649443663291386Clostridium tetani E88, complete genomeDNA-directed RNA polymerase subunit N4e-70265
NC_010718:2116889:2130614213061421320531440Natranaerobius thermophilus JW/NM-WN-LF, complete genomeRNA polymerase, sigma 54 subunit, RpoN3e-69262
NC_016629:3496630:3497649349764934990911443Desulfovibrio africanus str. Walvis Bay chromosome, completeRNA polymerase sigma 54 subunit RpoN2e-68260
NC_013939:1023443:1041561104156110429491389Deferribacter desulfuricans SSM1, complete genomeDNA-directed RNA polymerase sigma 54 factor1e-67257
NC_020409:560278:5755695755695769751407Desulfovibrio piezophilus str. nov C1TLV30 chromosome, completeRNA polymerase, sigma 54 subunit, RpoN2e-67256
NC_013223:1848689:1848689184868918501131425Desulfohalobium retbaense DSM 5692, complete genomeRNA polymerase, sigma 54 subunit, RpoN1e-66254
NC_011296:229494:2356562356562370711416Thermodesulfovibrio yellowstonii DSM 11347, complete genomeRNA polymerase sigma-54 factor8e-67254
NC_016791:1980844:2004955200495520063131359Clostridium sp. BNL1100 chromosome, complete genomeRNA polymerase sigma-54 factor2e-66253
NC_002937:1706000:1712453171245317138831431Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough, completeRNA polymerase sigma-54 factor6e-66251
NC_016779:4825599:4839145483914548404521308Bacillus cereus F837/76 chromosome, complete genomeRNA polymerase sigma-54 factor RpoN4e-63242
NC_015731:990000:9900389900389914861449Nitrosomonas sp. Is79A3 chromosome, complete genomeRNA polymerase, sigma 54 subunit, RpoN5e-63242
NC_014335:4800500:4816802481680248181091308Bacillus cereus biovar anthracis str. CI chromosome, completeDNA-directed RNA polymerase subunit N1e-62240
NC_005957:4850659:4871644487164448729511308Bacillus thuringiensis serovar konkukian str. 97-27, completeDNA-directed RNA polymerase subunit N1e-62240
NC_011969:4802500:4813508481350848148151308Bacillus cereus Q1 chromosome, complete genomeRNA polymerase factor sigma-541e-62240
NC_007530:4853740:4865925486592548672321308Bacillus anthracis str. 'Ames Ancestor', complete genomeDNA-directed RNA polymerase subunit N4e-62239
NC_005945:4854951:4867136486713648684431308Bacillus anthracis str. Sterne, complete genomeDNA-directed RNA polymerase subunit N4e-62239
NC_003997:4852332:4865799486579948671061308Bacillus anthracis str. Ames, complete genomeDNA-directed RNA polymerase subunit N4e-62239
NC_012581:4856620:4868248486824848695551308Bacillus anthracis str. CDC 684 chromosome, complete genomeRNA polymerase factor sigma-544e-62239
NC_012659:4853640:4865825486582548671321308Bacillus anthracis str. A0248, complete genomeRNA polymerase factor sigma-544e-62239
NC_003909:4831000:4842212484221248435191308Bacillus cereus ATCC 10987, complete genomeDNA-directed RNA polymerase subunit N3e-62239
NC_008600:4868000:4878994487899448803701377Bacillus thuringiensis str. Al Hakam, complete genomeRNA polymerase sigma-54 factor2e-62239
NC_006274:4910465:4924166492416649254731308Bacillus cereus E33L, complete genomeDNA-directed RNA polymerase subunit N2e-62239
NC_012472:4867210:4880770488077048820771308Bacillus cereus 03BB102, complete genomeRNA polymerase sigma-54 factor2e-62239
NC_011773:4914601:4928293492829349296001308Bacillus cereus AH820 chromosome, complete genomeRNA polymerase factor sigma-542e-62239
NC_017200:4915780:4929322492932249306291308Bacillus thuringiensis serovar finitimus YBT-020 chromosome,RNA polymerase factor sigma-542e-62239
NC_011658:4866184:4879877487987748811841308Bacillus cereus AH187 chromosome, complete genomeRNA polymerase factor sigma-542e-62239
NC_016771:4821000:4832200483220048335071308Bacillus cereus NC7401, complete genomeRNA polymerase sigma-54 factor2e-62239
NC_011725:5043198:5056824505682450581311308Bacillus cereus B4264 chromosome, complete genomeRNA polymerase factor sigma-549e-62238
NC_014171:4933200:4946549494654949478561308Bacillus thuringiensis BMB171 chromosome, complete genomeRNA polymerase factor sigma-547e-62238
NC_017208:5096759:5110398511039851117051308Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeRNA polymerase factor sigma-547e-62238
NC_004722:5027762:5045127504512750464341308Bacillus cereus ATCC 14579, complete genomeDNA-directed RNA polymerase subunit N1e-61237
NC_009674:3732000:3744642374464237459491308Bacillus cytotoxicus NVH 391-98 chromosome, complete genomeRNA polymerase factor sigma-542e-61236
NC_010184:4879552:4897907489790748992711365Bacillus weihenstephanensis KBAB4, complete genomeRNA polymerase, sigma 54 subunit, RpoN3e-61236
NC_009656:5185704:5187742518774251892351494Pseudomonas aeruginosa PA7 chromosome, complete genomeRNA polymerase factor sigma-546e-61235
NC_011772:4994500:5010589501058950118961308Bacillus cereus G9842, complete genomeRNA polymerase sigma-54 factor1e-60234
NC_021171:4588792:4607102460710246084061305Bacillus sp. 1NLA3E, complete genomeRNA polymerase factor sigma-542e-58226
NC_011894:3988500:4010566401056640120771512Methylobacterium nodulans ORS 2060, complete genomeRNA polymerase, sigma 54 subunit, RpoN3e-56219
NC_010611:679862:6925266925266939741449Acinetobacter baumannii ACICU, complete genomeDNA-directed RNA polymerase specialized sigma subunit1e-55217
NC_010410:3166279:3170517317051731719651449Acinetobacter baumannii AYE, complete genomeRNA polymerase sigma-54 factor2e-55217
NC_017249:8221992:8221992822199282234881497Bradyrhizobium japonicum USDA 6, complete genomeRNA polymerase sigma-54 subunit2e-54214
NC_004463:1992000:2037374203737420388281455Bradyrhizobium japonicum USDA 110, complete genomeDNA-directed RNA polymerase subunit N1e-54214
NC_020125:1:5879587973481470Riemerella anatipestifer RA-CH-2, complete genomehypothetical protein3e-54213
NC_015064:1355065:1364809136480913665211713Acidobacterium sp. MP5ACTX9 chromosome, complete genomeRNA polymerase, sigma 54 subunit, RpoN7e-53208
NC_009615:3818500:3834117383411738355741458Parabacteroides distasonis ATCC 8503 chromosome, complete genomeRNA polymerase sigma-541e-52207
NC_013355:1087807:1089447108944710909461500Zymomonas mobilis subsp. mobilis NCIB 11163, complete genomeRNA polymerase, sigma 54 subunit, RpoN2e-51204
NC_012440:373863:3853393853393866431305Persephonella marina EX-H1, complete genomeRNA polymerase sigma-54 factor1e-51204
NC_019904:56145:7168671686731371452Echinicola vietnamensis DSM 17526 chromosome, complete genomeRNA polymerase sigma-54 factor1e-51204
NC_015914:3197772:3201840320184032032941455Cyclobacterium marinum DSM 745 chromosome, complete genomeRNA polymerase, sigma 54 subunit, RpoN2e-50200
NC_018145:1089548:1089548108954810910981551Zymomonas mobilis subsp. mobilis ATCC 29191 chromosome, completeRNA polymerase sigma 54 subunit RpoN3e-50199
NC_013730:778076:7918847918847933351452Spirosoma linguale DSM 74, complete genomeRNA polymerase, sigma 54 subunit, RpoN7e-49195
NC_015160:3180193:3199719319971932012301512Odoribacter splanchnicus DSM 20712 chromosome, complete genomeRNA polymerase, sigma 54 subunit, RpoN2e-48193
NC_017080:1194199:1212529121252912141211593Phycisphaera mikurensis NBRC 102666, complete genomeRNA polymerase sigma-54 factor2e-46187
NC_006677:2012841:2012841201284120141571317Gluconobacter oxydans 621H, complete genomeRNA polymerase sigma-54 factor RpoN6e-46185
NC_004663:3143198:3144919314491931464031485Bacteroides thetaiotaomicron VPI-5482, complete genomeRNA polymerase sigma-544e-45182
NC_017271:2278500:2297507229750722989581452Xanthomonas campestris pv. raphani 756C chromosome, completeRNA polymerase sigma-54 factor5e-45182
NC_003228:4895326:4900356490035649018341479Bacteroides fragilis NCTC 9343, complete genomeputative RNA polymerase sigma-54 factor4e-44179
NC_016776:4982094:4987123498712349886011479Bacteroides fragilis 638R, complete genomeputative RNA polymerase sigma-54 factor4e-44179
NC_006347:4961865:4966892496689249683701479Bacteroides fragilis YCH46, complete genomeRNA polymerase sigma-544e-44179
NC_007508:2277640:2297360229736022987631404Xanthomonas campestris pv. vesicatoria str. 85-10, complete genomeRNA polymerase sigma-54 factor4e-44179
NC_015500:533528:5523685523685539301563Treponema brennaborense DSM 12168 chromosome, complete genomeRNA polymerase, sigma 54 subunit, RpoN7e-44178
NC_019908:1512622:1529515152951515307831269Brachyspira pilosicoli P43/6/78 chromosome, complete genomeRNA polymerase sigma 54 subunit RpoN5e-42172
NC_020911:2998000:2998146299814629994921347Octadecabacter antarcticus 307, complete genomeRNA polymerase sigma-54 factor RpoN2e-41170
NC_015577:676453:6966976966976982381542Treponema azotonutricium ZAS-9 chromosome, complete genomeRNA polymerase sigma-54 factor4e-41169
NC_015578:1430112:1452788145278814541461359Treponema primitia ZAS-2 chromosome, complete genomeRNA polymerase sigma-54 factor3e-41169
NC_015873:380485:3989143989144001911278Megasphaera elsdenii DSM 20460, complete genomeRNA polymerase sigma-54 factor1e-34147
NC_012115:691154:7151227151227163541233Nautilia profundicola AmH, complete genomeRNA polymerase sigma-54 factor2e-34147
NC_017192:20404:3518335183364301248Arcobacter sp. L, complete genomeRNA polymerase factor sigma-543e-29130
NC_014960:1887000:1898536189853618999391404Anaerolinea thermophila UNI-1, complete genomeRNA polymerase sigma-54 factor3e-27123
NC_013949:1163456:1184644118464411859181275Helicobacter mustelae 12198 chromosome, complete genomeRNA polymerase sigma-54 factor4e-27122
NC_003911:4001094:4008387400838740096701284Silicibacter pomeroyi DSS-3, complete genomeRNA polymerase sigma-54 factor1e-24114
NC_014166:33138:5479454794560411248Arcobacter nitrofigilis DSM 7299 chromosome, complete genomeRNA polymerase sigma-54 factor subunit RpoN9e-24111
NC_021508:107384:1269841269841284111428Treponema pallidum subsp. pallidum SS14, complete genomeDNA-directed RNA polymerase sigma subunit RpoN2e-1894
NC_000919:107373:1269741269741284011428Treponema pallidum subsp. pallidum str. Nichols, complete genomeRNA polymerase sigma-54 factor (rpoN)2e-1894
NC_010741:107370:1269711269711283981428Treponema pallidum subsp. pallidum SS14, complete genomeRNA polymerase sigma-54 factor2e-1894
NC_017268:107387:1269251269251284151491Treponema pallidum subsp. pallidum str. Chicago chromosome,RNA polymerase sigma-54 factor3e-1893.2
NC_016844:107382:1269201269201284101491Treponema pallidum subsp. pallidum DAL-1 chromosome, completeDNA-directed RNA polymerase sigma subunit RpoN3e-1893.2
NC_009718:1272296:127475012747501275544795Fervidobacterium nodosum Rt17-B1, complete genomesigma-54 DNA-binding domain-containing protein3e-1377