Pre_GI: BLASTP Hits

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Query: NC_017179:3540739:3541806 Clostridium difficile BI1, complete genome

Start: 3541806, End: 3542828, Length: 1023

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:3532721:3533788353378835348101023Clostridium difficile CD196 chromosome, complete genomecentral glycolytic genes regulator0660
NC_014614:757381:7599187599187609581041Clostridium sticklandii, complete genometranscriptional regulator3e-82305
NC_004557:363628:3664713664713674991029Clostridium tetani E88, complete genomeputative central glycolytic genes regulator1e-80300
NC_014328:4249032:4262005426200542630301026Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative transcriptional regulator1e-71270
NC_020291:5641444:5652749565274956537981050Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomecentral glycolytic genes regulator2e-70266
NC_009697:256354:2590692590692601001032Clostridium botulinum A str. ATCC 19397 chromosome, completecentral glycolytic genes regulator4e-70265
NC_015425:604842:6064226064226074831062Clostridium botulinum BKT015925 chromosome, complete genometranscriptional regulator3e-66252
NC_015519:2045935:2059066205906620601181053Tepidanaerobacter sp. Re1 chromosome, complete genomeDeoR family transcriptional regulator2e-61236
NC_003909:4831000:4840793484079348418211029Bacillus cereus ATCC 10987, complete genomegapA transcriptional regulator CggR2e-59229
NC_005957:4850659:4870225487022548712531029Bacillus thuringiensis serovar konkukian str. 97-27, completecentral glycolytic genes regulator2e-59229
NC_014335:4800500:4815383481538348164111029Bacillus cereus biovar anthracis str. CI chromosome, completecentral glycolytic genes regulator2e-59229
NC_012472:4867210:4879350487935048803781029Bacillus cereus 03BB102, complete genomegapA transcriptional regulator CggR2e-59229
NC_003997:4852332:4864379486437948654071029Bacillus anthracis str. Ames, complete genomegapA transcriptional regulator CggR2e-59229
NC_006274:4910465:4922747492274749237751029Bacillus cereus E33L, complete genomecentral glycolytic genes regulator2e-59229
NC_008600:4868000:4877574487757448786171044Bacillus thuringiensis str. Al Hakam, complete genomecentral glycolytic genes regulator2e-59229
NC_007530:4853740:4864505486450548655331029Bacillus anthracis str. 'Ames Ancestor', complete genomegapa transcriptional regulator cggr2e-59229
NC_005945:4854951:4865716486571648667441029Bacillus anthracis str. Sterne, complete genomegapA transcriptional regulator CggR2e-59229
NC_011658:4866184:4878458487845848794861029Bacillus cereus AH187 chromosome, complete genomegapA transcriptional regulator CggR2e-59229
NC_017200:4915780:4927903492790349289311029Bacillus thuringiensis serovar finitimus YBT-020 chromosome,central glycolytic genes regulator2e-59229
NC_016779:4825599:4837725483772548387531029Bacillus cereus F837/76 chromosome, complete genomeCentral glycolytic genes regulator2e-59229
NC_016771:4821000:4830781483078148318091029Bacillus cereus NC7401, complete genomegapA transcriptional regulator CggR2e-59229
NC_012659:4853640:4864405486440548654331029Bacillus anthracis str. A0248, complete genomegapA transcriptional regulator CggR2e-59229
NC_012581:4856620:4866828486682848678561029Bacillus anthracis str. CDC 684 chromosome, complete genomegapA transcriptional regulator CggR2e-59229
NC_011969:4802500:4812089481208948131171029Bacillus cereus Q1 chromosome, complete genomecentral glycolytic genes regulator2e-59229
NC_011773:4914601:4926873492687349279011029Bacillus cereus AH820 chromosome, complete genomegapA transcriptional regulator CggR2e-59229
NC_009674:3732000:3743224374322437442521029Bacillus cytotoxicus NVH 391-98 chromosome, complete genomeDeoR family transcriptional regulator1e-58226
NC_016941:807155:8150918150918161041014Staphylococcus aureus subsp. aureus MSHR1132, complete genomeglycolytic operon regulator2e-58226
NC_009487:866000:8734438734438744561014Staphylococcus aureus subsp. aureus JH9 chromosome, completeDeoR family transcriptional regulator4e-57222
NC_010718:2116889:2129349212934921303771029Natranaerobius thermophilus JW/NM-WN-LF, complete genometranscriptional regulator, DeoR family4e-57221
NC_013205:2332174:2335308233530823363811074Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,transcriptional regulator, DeoR family5e-57221
NC_004722:5027762:5043707504370750447501044Bacillus cereus ATCC 14579, complete genomeCentral glycolytic genes regulator6e-56218
NC_011772:4994500:5009169500916950101971029Bacillus cereus G9842, complete genomegapA transcriptional regulator CggR5e-56218
NC_011725:5043198:5055404505540450564321029Bacillus cereus B4264 chromosome, complete genomegapA transcriptional regulator CggR5e-56218
NC_014171:4933200:4945129494512949461571029Bacillus thuringiensis BMB171 chromosome, complete genomecentral glycolytic genes regulator5e-56218
NC_017208:5096759:5108978510897851100061029Bacillus thuringiensis serovar chinensis CT-43 chromosome, completecentral glycolytic genes regulator5e-56218
NC_007350:1971762:1984033198403319850611029Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305,glycolytic operon regulator1e-55217
NC_010184:4879552:4896488489648848975161029Bacillus weihenstephanensis KBAB4, complete genometranscriptional regulator, DeoR family1e-55217
NC_017353:2129738:2142147214214721431661020Staphylococcus lugdunensis N920143, complete genomeglycolytic operon regulator1e-54214
NC_015519:686027:687874687874688818945Tepidanaerobacter sp. Re1 chromosome, complete genomeDeoR family transcriptional regulator7e-1891.7
NC_009698:3526359:353221035322103533181972Clostridium botulinum A str. Hall chromosome, complete genomeglucitol operon regulator1e-1480.9
NC_009697:3629250:363510136351013636072972Clostridium botulinum A str. ATCC 19397 chromosome, completeglucitol operon regulator1e-1480.9
NC_010520:3753875:375967837596783760649972Clostridium botulinum A3 str. Loch Maree, complete genomeputative glucitol operon regulator2e-1480.1
NC_013517:3997448:400404740040474005012966Sebaldella termitidis ATCC 33386, complete genometranscriptional regulator, DeoR family3e-1479.3
NC_012658:3744000:375002637500263750997972Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative glucitol operon regulator4e-1479.3
NC_012563:3921859:392701539270153927986972Clostridium botulinum A2 str. Kyoto, complete genomeputative glucitol operon regulator4e-1479.3
NC_010516:3724312:373016437301643731135972Clostridium botulinum B1 str. Okra, complete genomeputative glucitol operon regulator4e-1479.3
NC_014377:1400544:140441214044121405368957Thermosediminibacter oceani DSM 16646 chromosome, complete genometranscriptional regulator, DeoR family9e-1478.2
NC_006322:4048990:406544740654474066385939Bacillus licheniformis ATCC 14580, complete genomeDeoR1e-1377.8
NC_006270:4048876:406533340653334066271939Bacillus licheniformis ATCC 14580, complete genometranscriptional regulator1e-1377.8
NC_009699:3753599:376194337619433762914972Clostridium botulinum F str. Langeland chromosome, complete genomeglucitol operon regulator1e-1377.8
NC_017297:3752000:376055637605563761527972Clostridium botulinum F str. 230613 chromosome, complete genomeputative glucitol operon regulator1e-1377.8
NC_014923:1680095:170472417047241705704981Mesorhizobium ciceri biovar biserrulae WSM1271 chromosome, completesugar-binding domain-containing protein9e-1374.7
NC_013199:392450:409023409023409970948Lactobacillus rhamnosus Lc 705, complete genometranscriptional regulator, SorR, sorbitol operon regulator5e-1272.4
NC_014364:3707311:371045937104593711397939Spirochaeta smaragdinae DSM 11293 chromosome, complete genometranscriptional regulator, DeoR family3e-1169.7
NC_002570:832480:844531844531845481951Bacillus halodurans C-125, complete genometranscriptional regulator4e-1169.3
NC_021064:1789980:179671917967191797663945Propionibacterium avidum 44067, complete genometranscriptional regulator deoR family protein1e-0861.2
NC_009655:195500:208793208793209746954Actinobacillus succinogenes 130Z chromosome, complete genomeDeoR family transcriptional regulator3e-0859.7
NC_014364:815346:841673841673842638966Spirochaeta smaragdinae DSM 11293 chromosome, complete genometranscriptional regulator, DeoR family3e-0859.7
NC_003047:3202125:320716032071603208107948Sinorhizobium meliloti 1021, complete genomePUTATIVE TRANSCRIPTIONAL REGULATOR PROTEIN9e-0858.2
NC_012704:1641684:165346716534671654402936Corynebacterium kroppenstedtii DSM 44385, complete genometranscriptional regulator, DeoR family1e-0757.8
NC_014532:3479674:349149834914983492457960Halomonas elongata DSM 2581, complete genomeK05346 deoxyribonucleoside regulator1e-0654.7
NC_012962:1661683:1661683166168316626901008Photorhabdus asymbiotica, complete genomeputative transcriptional regulator, sorc family (putative sorc-typ transcriptional regulator)2e-0653.5