Pre_GI: BLASTP Hits

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Query: NC_017179:3222015:3238771 Clostridium difficile BI1, complete genome

Start: 3238771, End: 3239433, Length: 663

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:3214063:323081932308193231481663Clostridium difficile CD196 chromosome, complete genomehypothetical protein5e-124443
NC_011567:2327870:233042923304292331130702Anoxybacillus flavithermus WK1, complete genomeSolo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta3e-22105
NC_009051:1074993:109838010983801099030651Methanoculleus marisnigri JR1, complete genomeB3/4 domain protein7e-1167.4
NC_009699:1122000:114397211439721144670699Clostridium botulinum F str. Langeland chromosome, complete genomeB3/4 domain-containing protein2e-1065.9
NC_016593:762216:782816782816783526711Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completeSolo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta2e-0756.2
NC_017243:599814:619961619961620665705Brachyspira intermedia PWS/A chromosome, complete genomehypothetical protein2e-0652.4