Pre_GI: BLASTP Hits

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Query: NC_017179:3222015:3227384 Clostridium difficile BI1, complete genome

Start: 3227384, End: 3228052, Length: 669

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:3214063:321943232194323220100669Clostridium difficile CD196 chromosome, complete genomeV-type ATP synthase subunit D1e-110398
NC_009697:2680607:268551526855152686165651Clostridium botulinum A str. ATCC 19397 chromosome, completeV-type ATP synthase subunit D6e-58223
NC_012563:2979147:298666729866672987317651Clostridium botulinum A2 str. Kyoto, complete genomeV-type ATPase, D subunit6e-58223
NC_010520:2807429:283366928336692834319651Clostridium botulinum A3 str. Loch Maree, complete genomeV-type ATPase, D subunit2e-57222
NC_015425:906969:921056921056921706651Clostridium botulinum BKT015925 chromosome, complete genomeV-type ATPase subunit D5e-57220
NC_008593:841291:855448855448856098651Clostridium novyi NT, complete genomeV-type ATPase, D subunit6e-57220
NC_008262:1795914:179778117977811798425645Clostridium perfringens SM101, complete genomeV-type ATPase, D subunit3e-56218
NC_003366:1901898:190842019084201909064645Clostridium perfringens str. 13, complete genomeATP synthase subunit D3e-56218
NC_008261:2117207:212373021237302124374645Clostridium perfringens ATCC 13124, complete genomeV-type ATPase, D subunit3e-56218
NC_010674:2930259:293543429354342936075642Clostridium botulinum B str. Eklund 17B, complete genomeV-type ATPase, D subunit2e-56218
NC_010723:2735196:273974727397472740388642Clostridium botulinum E3 str. Alaska E43, complete genomeV-type ATPase, D subunit2e-56218
NC_014377:2033781:205197420519742052600627Thermosediminibacter oceani DSM 16646 chromosome, complete genomeV-type ATPase, D subunit4e-53207
NC_013192:815854:830256830256830894639Leptotrichia buccalis DSM 1135, complete genomeV-type ATPase, D subunit2e-52205
NC_010321:2319820:232635023263502326979630Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeV-type ATP synthase subunit D7e-52203
NC_010320:2397395:240560224056022406231630Thermoanaerobacter sp. X514 chromosome, complete genomeV-type ATP synthase subunit D7e-52203
NC_014964:2301835:230836523083652308988624Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeV-type ATPase subunit D8e-52203
NC_014538:2396559:240476624047662405389624Thermoanaerobacter sp. X513 chromosome, complete genomeV-type ATPase subunit D8e-52203
NC_013921:2375900:238379023837902384413624Thermoanaerobacter italicus Ab9 chromosome, complete genomeV-type ATPase, D subunit2e-51202
NC_014209:2257316:226520822652082265831624Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,V-type ATPase, D subunit2e-51202
NC_016148:1021138:102576110257611026387627Thermovirga lienii DSM 17291 chromosome, complete genomeV-type ATPase subunit D3e-45181
NC_009785:130252:142467142467143090624Streptococcus gordonii str. Challis substr. CH1, complete genomeV-type ATPase, D subunit3e-41168
NC_005791:1028500:103995910399591040603645Methanococcus maripaludis S2, complete genomeV-type ATP synthase subunit D2e-31135
NC_015847:1119666:113407311340731134717645Methanococcus maripaludis XI chromosome, complete genomeV-type ATP synthase subunit D2e-31135
NC_009135:494949:500567500567501202636Methanococcus maripaludis C5, complete genomeV-type ATPase, D subunit2e-31135
NC_009637:302881:317145317145317789645Methanococcus maripaludis C7 chromosome, complete genomeV-type ATP synthase subunit D7e-31133
NC_015562:627000:640311640311640961651Methanotorris igneus Kol 5 chromosome, complete genomeV-type ATP synthase subunit D1e-30132
NC_009975:1500978:150600215060021506646645Methanococcus maripaludis C6, complete genomeV-type ATPase, D subunit1e-30132
NC_015636:1477221:148322614832261483867642Methanothermococcus okinawensis IH1 chromosome, complete genomeV-type ATP synthase subunit D6e-30130
NC_015574:2057602:207208320720832072727645Methanobacterium sp. SWAN-1 chromosome, complete genomeV-type ATP synthase subunit D4e-29128
NC_009634:411599:426233426233426877645Methanococcus vannielii SB chromosome, complete genomeV-type ATP synthase subunit D4e-29128
NC_014222:186876:200412200412201047636Methanococcus voltae A3 chromosome, complete genomeV-type ATPase, D subunit4e-29127
NC_009635:61344:747947479475432639Methanococcus aeolicus Nankai-3 chromosome, complete genomeV-type ATP synthase subunit D1e-28126
NC_012883:1603744:161116816111681611812645Thermococcus sibiricus MM 739, complete genomeA1A0 ATP synthase, subunit D1e-27122
NC_013156:182896:208536208536209186651Methanocaldococcus fervens AG86, complete genomeV-type ATPase, D subunit3e-27121
NC_015216:405657:417885417885418526642Methanobacterium sp. AL-21 chromosome, complete genomeV-type ATP synthase subunit D2e-26119
NC_007681:1300068:130517913051791305823645Methanosphaera stadtmanae DSM 3091, complete genomeAhaD8e-25113
NC_000868:1730820:173729717372971737941645Pyrococcus abyssi GE5, complete genomeV-type ATP synthase subunit D8e-25113
NC_015474:723553:756758756758757402645Pyrococcus sp. NA2 chromosome, complete genomeV-type ATP synthase subunit D1e-24112
NC_003413:181525:195110195110195754645Pyrococcus furiosus DSM 3638, complete genomeV-type ATP synthase subunit D4e-24111
NC_012804:141914:145408145408146052645Thermococcus gammatolerans EJ3, complete genomeArchaeal/vacuolar-type H+-ATPase, subunit D (atpD)4e-24111
NC_018876:2403892:240700124070012407618618Methanolobus psychrophilus R15 chromosome, complete genomeV-type ATP synthase subunit D1e-21103
NC_013741:1390823:140274614027461403387642Archaeoglobus profundus DSM 5631, complete genomeV-type ATPase, D subunit2e-2099.4
NC_014507:245344:250436250436251068633Methanoplanus petrolearius DSM 11571 chromosome, complete genomeV-type ATPase subunit D9e-2097.1
NC_014624:2211771:223355522335552234181627Eubacterium limosum KIST612 chromosome, complete genomeV-type ATPase7e-1787.4
NC_018012:1935500:194824719482471948891645Thiocystis violascens DSM 198 chromosome, complete genomeH(+)-transporting ATP synthase, vacuolar type, subunit D2e-1479.3
NC_002689:46243:556225562256269648Thermoplasma volcanium GSS1, complete genomeV-type ATP synthase subunit D3e-1375.5
NC_005877:509877:516774516774517421648Picrophilus torridus DSM 9790, complete genomeV-type ATP synthase subunit D4e-1375.1
NC_014614:2434017:244290724429072443518612Clostridium sticklandii, complete genomeV-type sodium ATP synthase subunit D2e-1272.4
NC_014315:1042556:106561210656121066229618Nitrosococcus watsoni C-113 chromosome, complete genomeV-type ATPase subunit D1e-1169.7
NC_015152:1230995:123099512309951231693699Spirochaeta sp. Buddy chromosome, complete genomeV-type ATP synthase subunit D8e-1167
NC_016885:2091918:215013621501362150735600Pyrobaculum oguniense TE7 chromosome, complete genomeH(+)-transporting ATP synthase, vacuolar type, subunit D5e-0961.2
NC_009376:1:139051390514504600Pyrobaculum arsenaticum DSM 13514 chromosome, complete genomeV-type ATPase subunit D5e-0961.2
NC_016645:1838405:186876518687651869364600Pyrobaculum sp. 1860 chromosome, complete genomeV-type ATPase subunit D2e-0859.3
NC_010741:546573:571630571630572259630Treponema pallidum subsp. pallidum SS14, complete genomeV-type ATPase, subunit D1e-0757
NC_000919:545141:570198570198570827630Treponema pallidum subsp. pallidum str. Nichols, complete genomeV-type ATPase, subunit D (atpD-2)1e-0757
NC_016842:546661:571719571719572348630Treponema pallidum subsp. pertenue str. SamoaD chromosome, completetwo-sector ATPase, V(1) subunit D1e-0757
NC_016843:547149:572207572207572836630Treponema pallidum subsp. pertenue str. Gauthier chromosome,two-sector ATPase, V(1) subunit D1e-0757
NC_016844:547069:572127572127572756630Treponema pallidum subsp. pallidum DAL-1 chromosome, completetwo-sector ATPase, V(1) subunit D1e-0757
NC_016848:547115:572173572173572802630Treponema pallidum subsp. pertenue str. CDC2 chromosome, completetwo-sector ATPase, V(1) subunit D1e-0757
NC_017268:546376:571434571434572063630Treponema pallidum subsp. pallidum str. Chicago chromosome,V-type ATPase subunit D1e-0757
NC_021508:546592:571650571650572279630Treponema pallidum subsp. pallidum SS14, complete genometwo-sector ATPase, V(1) subunit D1e-0757
NC_007181:1295956:132536013253601325989630Sulfolobus acidocaldarius DSM 639, complete genomeV-type ATP synthase subunit D1e-0757
NC_012623:1119192:112731711273171127958642Sulfolobus islandicus Y.N.15.51 chromosome, complete genomeV-type ATP synthase subunit D2e-0755.8
NC_012589:1531725:154075815407581541399642Sulfolobus islandicus L.S.2.15, complete genomeV-type ATPase, D subunit2e-0755.8
NC_012588:1443753:145278614527861453427642Sulfolobus islandicus M.14.25 chromosome, complete genomeV-type ATP synthase subunit D2e-0755.8
NC_012622:1421098:143013114301311430772642Sulfolobus islandicus Y.G.57.14 chromosome, complete genomeV-type ATP synthase subunit D2e-0755.8
NC_012632:1568170:157720315772031577844642Sulfolobus islandicus M.16.27 chromosome, complete genomeV-type ATP synthase subunit D2e-0755.8
NC_012726:1431745:144077814407781441419642Sulfolobus islandicus M.16.4 chromosome, complete genomeV-type ATP synthase subunit D2e-0755.8
NC_013769:1528196:153722915372291537870642Sulfolobus islandicus L.D.8.5 chromosome, complete genomeV-type ATPase subunit D2e-0755.8
NC_017275:1486526:149555814955581496199642Sulfolobus islandicus HVE10/4 chromosome, complete genomeV-type ATPase subunit D2e-0755.8
NC_017276:1335474:134450713445071345148642Sulfolobus islandicus REY15A chromosome, complete genomeV-type ATPase subunit D2e-0755.8
NC_015714:542679:567743567743568372630Treponema paraluiscuniculi Cuniculi A chromosome, complete genometwo-sector ATPase, V(1) subunit D3e-0755.5
NC_003106:1435295:144323314432331443883651Sulfolobus tokodaii str. 7, complete genomeV-type ATP synthase subunit D8e-0753.9
NC_002754:491695:499646499646500287642Sulfolobus solfataricus P2, complete genomeV-type ATP synthase subunit D9e-0753.5
NC_015435:310406:319434319434320075642Metallosphaera cuprina Ar-4 chromosome, complete genomeV-type ATP synthase subunit D5e-0651.2