Pre_GI: BLASTP Hits

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Query: NC_017179:2895571:2910511 Clostridium difficile BI1, complete genome

Start: 2910511, End: 2911446, Length: 936

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:2887559:290249929024992903434936Clostridium difficile CD196 chromosome, complete genomeS-adenosyl-methyltransferase MraW9e-175612
NC_013316:2968000:298305729830572983992936Clostridium difficile R20291, complete genomeS-adenosyl-methyltransferase9e-175612
NC_020291:2873000:287736628773662878298933Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeribosomal RNA small subunit methyltransferase H6e-111400
NC_012563:1704345:172651317265131727442930Clostridium botulinum A2 str. Kyoto, complete genomeS-adenosyl-methyltransferase MraW5e-106384
NC_012658:1581486:158819615881961589125930Clostridium botulinum Ba4 str. 657 chromosome, complete genomeS-adenosyl-methyltransferase MraW2e-105382
NC_015520:1683616:168621016862101687148939Mahella australiensis 50-1 BON chromosome, complete genomeS-adenosyl-methyltransferase MraW4e-87321
NC_011725:3928853:394348639434863944418933Bacillus cereus B4264 chromosome, complete genomeS-adenosyl-methyltransferase MraW1e-86319
NC_006274:3805134:381964238196423820574933Bacillus cereus E33L, complete genomeS-adenosyl-methyltransferase MraW7e-86317
NC_014335:3675456:368996436899643690896933Bacillus cereus biovar anthracis str. CI chromosome, completeS-adenosyl-methyltransferase MraW7e-86317
NC_003997:3724702:373920337392033740135933Bacillus anthracis str. Ames, complete genomeS-adenosyl-methyltransferase MraW7e-86317
NC_007530:3724829:373933037393303740262933Bacillus anthracis str. 'Ames Ancestor', complete genomeS-adenosyl-methyltransferase MraW7e-86317
NC_012659:3724729:373923037392303740162933Bacillus anthracis str. A0248, complete genomeS-adenosyl-methyltransferase MraW7e-86317
NC_011772:3896635:390951339095133910445933Bacillus cereus G9842, complete genomeS-adenosyl-methyltransferase MraW6e-86317
NC_004722:3886800:390143339014333902365933Bacillus cereus ATCC 14579, complete genomeS-adenosyl-methyltransferase MraW6e-86317
NC_014171:3812247:382430338243033825235933Bacillus thuringiensis BMB171 chromosome, complete genomeS-adenosyl-methyltransferase MraW6e-86317
NC_017208:3928161:394108639410863942018933Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeS-adenosyl-methyltransferase MraW6e-86317
NC_005957:3746891:376139937613993762331933Bacillus thuringiensis serovar konkukian str. 97-27, completeS-adenosyl-methyltransferase MraW5e-86317
NC_005945:3725397:373989837398983740830933Bacillus anthracis str. Sterne, complete genomeS-adenosyl-methyltransferase MraW2e-85316
NC_016771:3665773:368028036802803681212933Bacillus cereus NC7401, complete genomeS-adenosyl-methyltransferase MraW3e-85315
NC_011969:3657360:367186836718683672800933Bacillus cereus Q1 chromosome, complete genomes-adenosyl-methyltransferase mraw4e-85315
NC_004606:470667:4888864888864898991014Streptococcus pyogenes SSI-1, complete genomeS-adenosyl-methyltransferase MraW9e-85313
NC_013192:815854:820581820581821507927Leptotrichia buccalis DSM 1135, complete genomeS-adenosyl-methyltransferase MraW2e-73275
NC_013895:397890:4108074108074118951089Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, completeS-adenosyl-methyltransferase MraW2e-72272
NC_013894:117644:139087139087139959873Thermocrinis albus DSM 14484 chromosome, complete genomeS-adenosyl-methyltransferase MraW4e-65248
NC_007645:6013242:601324260132426014171930Hahella chejuensis KCTC 2396, complete genomeS-adenosyl-methyltransferase MraW8e-65247
NC_017096:1147441:115080311508031151678876Caldisericum exile AZM16c01, complete genomeS-adenosyl-L-methionine-dependent methyltransferase MraW3e-63242
NC_017095:2143845:216242621624262163310885Fervidobacterium pennivorans DSM 9078 chromosome, complete genomeS-adenosyl-methyltransferase MraW7e-63241
NC_014550:2355500:236235523623552363347993Arthrobacter arilaitensis Re117, complete genomeS-adenosyl-L-methionine-dependent methyltransferase MraW6e-63241
NC_009615:2902871:294054329405432941460918Parabacteroides distasonis ATCC 8503 chromosome, complete genomeS-adenosyl-methyltransferase MraW8e-63240
NC_014448:414784:445120445120446016897Mycoplasma hyorhinis HUB-1 chromosome, complete genomeRibosomal RNA small subunit methyltransferase H2e-62239
NC_012560:1260031:127951812795181280459942Azotobacter vinelandii DJ, complete genomeS-adenosyl-methyltransferase MraW2e-61236
NC_009659:3384997:338854933885493389517969Janthinobacterium sp. Marseille chromosome, complete genomeS-adenosyl-methyltransferase MraW2e-60232
NC_009654:2958316:296560629656062966544939Marinomonas sp. MWYL1, complete genomeS-adenosyl-methyltransferase MraW2e-60232
NC_018697:361339:366732366732367667936Cycloclasticus sp. P1 chromosome, complete genomeRibosomal RNA small subunit methyltransferase H3e-60231
NC_013960:489616:493010493010493963954Nitrosococcus halophilus Nc4 chromosome, complete genomeS-adenosyl-methyltransferase MraW4e-60231
NC_012785:2010668:203200220320022032898897Kosmotoga olearia TBF 19.5.1, complete genomeS-adenosyl-methyltransferase MraW8e-60230
NC_014041:4093190:412509941250994125995897Zunongwangia profunda SM-A87 chromosome, complete genomeS-adenosyl-methyltransferase MraW2e-58226
NC_009901:4627998:464356946435694644516948Shewanella pealeana ATCC 700345, complete genomeS-adenosyl-methyltransferase MraW3e-58225
NC_016785:1586546:1596738159673815977571020Corynebacterium diphtheriae CDCE 8392 chromosome, complete genomeS-adenosyl-methyltransferase MraW5e-58224
NC_016799:1667338:1677524167752416785431020Corynebacterium diphtheriae 31A chromosome, complete genomeS-adenosyl-methyltransferase MraW7e-58224
NC_016800:1639373:1649559164955916505781020Corynebacterium diphtheriae BH8 chromosome, complete genomeS-adenosyl-methyltransferase MraW2e-57223
NC_009348:381752:396491396491397429939Aeromonas salmonicida subsp. salmonicida A449, complete genomeS-adenosyl-methyltransferase MraW2e-57223
NC_016783:1636820:1647006164700616480251020Corynebacterium diphtheriae INCA 402 chromosome, complete genomeS-adenosyl-methyltransferase MraW1e-57223
NC_016788:1609011:1619197161919716202161020Corynebacterium diphtheriae HC04 chromosome, complete genomeS-adenosyl-methyltransferase MraW1e-57223
NC_016790:1581411:1591597159159715926161020Corynebacterium diphtheriae VA01 chromosome, complete genomeS-adenosyl-methyltransferase MraW1e-57223
NC_016787:1605536:1615722161572216167411020Corynebacterium diphtheriae HC03 chromosome, complete genomeS-adenosyl-methyltransferase MraW1e-57223
NC_010003:903433:918635918635919495861Petrotoga mobilis SJ95, complete genomeS-adenosyl-methyltransferase MraW4e-57221
NC_015144:693958:712770712770713675906Weeksella virosa DSM 16922 chromosome, complete genomeribosomal RNA small subunit methyltransferase H5e-57221
NC_009613:2307698:232946523294652330340876Flavobacterium psychrophilum JIP02/86, complete genomeS-adenosyl-methyltransferase MraW5e-56218
NC_014934:2519999:252211825221182523026909Cellulophaga algicola DSM 14237 chromosome, complete genomeribosomal RNA small subunit methyltransferase h3e-56218
NC_016632:230500:234986234986235927942Serratia symbiotica str. 'Cinara cedri' chromosome, completeS-adenosyl-methyltransferase MraW2e-55216
NC_015696:1749863:176649917664991767416918Francisella sp. TX077308 chromosome, complete genomerRNA small subunit methyltransferase H8e-54211
NC_004545:229771:240931240931241878948Buchnera aphidicola str. Bp (Baizongia pistaciae), complete genomehypothetical protein2e-53209
NC_008601:631504:638482638482639399918Francisella tularensis subsp. novicida U112, complete genomeS-adenosylmethionine-dependent methyltransferase2e-53209
NC_007484:3231937:324964932496493250596948Nitrosococcus oceani ATCC 19707, complete genomemethyltransferase1e-52207
NC_006570:707280:714616714616715533918Francisella tularensis subsp. tularensis Schu 4, complete genomeS-adenosyl-methyltransferase7e-53207
NC_008245:707984:714568714568715485918Francisella tularensis subsp. tularensis FSC 198, complete genomeS-adenosyl-methyltransferase7e-53207
NC_007880:1456705:146996714699671470884918Francisella tularensis subsp. holarctica, complete genomeS-adenosyl-methyltransferase1e-52206
NC_016807:359916:372331372331373257927Mycoplasma pneumoniae 309, complete genomeS-adenosyl-methyltransferase MraW1e-52206
NC_004061:237205:248198248198249136939Buchnera aphidicola str. Sg (Schizaphis graminum), complete genomehypothetical 36.0 kDa protein2e-52206
NC_000912:356677:373829373829374755927Mycoplasma pneumoniae M129, complete genomeSAM-Dependent Methytransferase (Koonin for MG ortholog)2e-52206
NC_000908:253979:267081267081268010930Mycoplasma genitalium G37, complete genomeS-adenosyl-methyltransferase MraW5e-52204
NC_018497:252374:266891266891267820930Mycoplasma genitalium M6320 chromosome, complete genome16S rRNA m(4)C1402 methyltransferase5e-52204
NC_010336:213148:247290247290248216927Francisella philomiragia subsp. philomiragia ATCC 25017, completeS-adenosylmethionine-dependent methyltransferase5e-52204
NC_011126:779500:805743805743806633891Hydrogenobaculum sp. Y04AAS1, complete genomeS-adenosyl-methyltransferase MraW2e-51202
NC_015587:765500:792313792313793203891Hydrogenobaculum sp. SHO chromosome, complete genomeRibosomal RNA small subunit methyltransferase H6e-51201
NC_015557:765500:792258792258793148891Hydrogenobaculum sp. 3684 chromosome, complete genomeS-adenosyl-methyltransferase MraW6e-51201
NC_020411:765500:792285792285793175891Hydrogenobaculum sp. HO, complete genomeS-adenosyl-methyltransferase MraW6e-51201
NC_016937:707279:714633714633715532900Francisella tularensis subsp. tularensis TI0902 chromosome,hypothetical protein2e-50199
NC_016933:783938:790540790540791439900Francisella tularensis TIGB03 chromosome, complete genomehypothetical protein2e-50199
NC_015152:1341353:136430313643031365193891Spirochaeta sp. Buddy chromosome, complete genomeribosomal RNA small subunit methyltransferase H3e-50199
NC_016148:1021138:102740710274071028318912Thermovirga lienii DSM 17291 chromosome, complete genomeS-adenosyl-methyltransferase MraW4e-50198
NC_019908:982471:100346310034631004356894Brachyspira pilosicoli P43/6/78 chromosome, complete genomeS-adenosyl-methyltransferase MraW4e-49195
NC_005955:1029435:105305910530591054057999Bartonella quintana str. Toulouse, complete genomeS-adenosyl-methyltransferase3e-49195
NC_018607:1803500:182324118232411824134894Brachyspira pilosicoli B2904 chromosome, complete genomeprotein MraW6e-49194
NC_013209:2032500:2054739205473920557461008Acetobacter pasteurianus IFO 3283-01, complete genomemethytransferase MraW4e-48191
NC_017100:2035000:2057379205737920583861008Acetobacter pasteurianus IFO 3283-03, complete genomemethytransferase MraW4e-48191
NC_017108:2032500:2054716205471620557231008Acetobacter pasteurianus IFO 3283-12, complete genomemethytransferase MraW4e-48191
NC_017111:2032500:2054734205473420557411008Acetobacter pasteurianus IFO 3283-32, complete genomemethytransferase MraW4e-48191
NC_017121:2032500:2054721205472120557281008Acetobacter pasteurianus IFO 3283-07, complete genomemethytransferase MraW4e-48191
NC_017125:2035000:2057359205735920583661008Acetobacter pasteurianus IFO 3283-22, complete genomemethytransferase MraW4e-48191
NC_017146:2035000:2057401205740120584081008Acetobacter pasteurianus IFO 3283-26, complete genomemethytransferase MraW4e-48191
NC_017150:1940000:1962485196248519634921008Acetobacter pasteurianus IFO 3283-01-42C, complete genomemethytransferase MraW4e-48191
NC_020301:1132927:1156482115648211575311050Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomeS-adenosyl-methyltransferase1e-47190
NC_020300:1041523:1065093106509310661391047Bartonella australis Aust/NH1, complete genomeS-adenosyl-methyltransferase1e-47190
NC_008710:277207:316401316401317294894Borrelia turicatae 91E135, complete genomeS-adenosyl-methyltransferase MraW2e-45182
NC_007797:692944:711865711865712752888Anaplasma phagocytophilum HZ, complete genomeS-adenosyl-methyltransferase MraW4e-43175
NC_011244:319373:336334336334337227894Borrelia recurrentis A1, complete genomeS-adenosyl-methyltransferase2e-41169
NC_015155:347231:347231347231348145915Mycoplasma suis str. Illinois chromosome, complete genomes-adenosyl-methyltransferase MraW9e-40164
NC_005070:2181000:219405821940582194705648Synechococcus sp. WH 8102, complete genomehypothetical protein1e-20100
NC_005070:2181000:219381421938142194065252Synechococcus sp. WH 8102, complete genomehypothetical protein3e-1169.7