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Query: NC_017179:2895571:2899607 Clostridium difficile BI1, complete genome

Start: 2899607, End: 2900305, Length: 699

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:2887559:289159528915952892293699Clostridium difficile CD196 chromosome, complete genomehypothetical protein1e-107389
NC_013316:2968000:297215329721532972851699Clostridium difficile R20291, complete genomehypothetical protein1e-107389
NC_017179:2895571:289892828989282899602675Clostridium difficile BI1, complete genomehypothetical protein7e-1477.4
NC_013315:2887559:289091628909162891590675Clostridium difficile CD196 chromosome, complete genomehypothetical protein7e-1477.4
NC_013316:2968000:297147429714742972148675Clostridium difficile R20291, complete genomehypothetical protein7e-1477.4
NC_011898:649000:662576662576663286711Clostridium cellulolyticum H10, complete genomeprotein of unknown function DUF8819e-1167.4
NC_011898:649000:661867661867662598732Clostridium cellulolyticum H10, complete genomeprotein of unknown function DUF8812e-0962.8
NC_018750:1092224:109689110968911097823933Streptomyces venezuelae ATCC 10712, complete genomeDivision initiation protein4e-0961.6
NC_021064:1211480:123369612336961234448753Propionibacterium avidum 44067, complete genomehypothetical protein7e-0754.3