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Query: NC_017179:2895571:2898476 Clostridium difficile BI1, complete genome

Start: 2898476, End: 2898829, Length: 354

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:2887559:289046428904642890817354Clostridium difficile CD196 chromosome, complete genomehypothetical protein9e-51198
NC_020291:2873000:289073728907372891129393Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein6e-1682.8
NC_018750:1092224:109782010978201098152333Streptomyces venezuelae ATCC 10712, complete genomehypothetical protein2e-0961.6
NC_009953:2867864:288097128809712881303333Salinispora arenicola CNS-205 chromosome, complete genomehypothetical protein1e-1065.1
NC_013316:2968000:297102229710222971375354Clostridium difficile R20291, complete genomehypothetical protein9e-51198
NC_009380:2664419:267895226789522679284333Salinispora tropica CNB-440 chromosome, complete genomehypothetical protein6e-1166.2
NC_014220:837926:837926837926838261336Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomeprotein of unknown function DUF12906e-2199.4
NC_012658:1581486:159902815990281599378351Clostridium botulinum Ba4 str. 657 chromosome, complete genomesmall basic protein5e-2096.3
NC_021064:1211480:123444112344411234773333Propionibacterium avidum 44067, complete genomesmall basic protein1e-0961.6