Pre_GI: BLASTP Hits

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Query: NC_017179:2513804:2534395 Clostridium difficile BI1, complete genome

Start: 2534395, End: 2534817, Length: 423

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:2505792:252638325263832526805423Clostridium difficile CD196 chromosome, complete genomePTS system mannitol-specific transporter subunit IIA2e-75280
NC_013316:2585666:260693926069392607361423Clostridium difficile R20291, complete genomePTS system, mannitol-specific IIa component2e-75280
NC_009617:263060:280258280258280698441Clostridium beijerinckii NCIMB 8052 chromosome, complete genomephosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 21e-30131
NC_002951:2208813:221253022125302212964435Staphylococcus aureus subsp. aureus COL, complete genomePTS system, mannitol-specific IIA component2e-28124
NC_017341:2303005:230672223067222307156435Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, MtlA_12e-28124
NC_013282:116649:1331691331691350881920Cronobacter turicensis, complete genomePTS system mannitol-specific EIICBA component2e-28124
NC_013416:1748848:1751676175167617535561881Aggregatibacter actinomycetemcomitans D11S-1, complete genomePTS system, mannitol-specific IIC subunit1e-27121
CP002516:119935:1288891288891308021914Escherichia coli KO11, complete genomePTS system, mannitol-specific IIC subunit3e-27120
NC_010468:111504:1206321206321225451914Escherichia coli ATCC 8739, complete genomePTS system, mannitol-specific IIC subunit3e-27120
CP002185:3964500:3975271397527139771841914Escherichia coli W, complete genomefused mannitol-specific PTS enzymes: IIA components/IIB components/IIC components3e-27120
CU928145:4131924:4144171414417141460841914Escherichia coli 55989 chromosome, complete genomefused mannitol-specific PTS enzymes: IIA components ; IIB components ; IIC components3e-27120
AP010958:4707712:4709542470954247114551914Escherichia coli O103:H2 str. 12009 DNA, complete genomefused mannitol-specific PTS enzymes: IIA component /IIB component/IIC component3e-27120
NC_004337:3590323:3738310373831037402231914Shigella flexneri 2a str. 301, complete genomePTS system, mannitol-specific enzyme IIABC components3e-27120
NC_011748:4131924:4144171414417141460841914Escherichia coli 55989, complete genomefused mannitol-specific PTS enzymes: IIA components ; IIB components ; IIC components3e-27120
NC_004603:370320:3703203703203722721953Vibrio parahaemolyticus RIMD 2210633 chromosome I, completePTS system, mannitol-specific IIABC component3e-27120
NC_009800:3787320:3798811379881138007241914Escherichia coli HS, complete genomePTS system, mannitol-specific IIABC component3e-27120
NC_009801:4073968:4085443408544340873561914Escherichia coli E24377A, complete genomePTS system, mannitol-specific IIABC component3e-27120
NC_016513:2103958:2105771210577121076511881Aggregatibacter actinomycetemcomitans ANH9381 chromosome, completePTS system mannitol-specific transporter subunit IIC2e-27120
NC_010498:3988351:4007925400792540098381914Escherichia coli SMS-3-5, complete genomePTS system, mannitol-specific IIABC component2e-27120
NC_016902:119935:1288891288891308021914Escherichia coli KO11FL chromosome, complete genomePTS system mannitol-specific transporter subunit IIC3e-27120
NC_013353:4707712:4709542470954247114551914Escherichia coli O103:H2 str. 12009, complete genomefused mannitol-specific PTS enzymes: IIA component /IIB component/IIC component3e-27120
NC_012967:3696877:3706974370697437088871914Escherichia coli B str. REL606 chromosome, complete genomePTS system mannitol-specific transporter subunit IIABC3e-27120
NC_012947:126596:1355501355501374631914Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completePTS system, mannitol-specific IIC subunit3e-27120
NC_012759:3648500:3658630365863036605431914Escherichia coli BW2952 chromosome, complete genomefused mannitol-specific PTS enzymes: IIA components/IIB components/IIC components3e-27120
NC_011415:4006500:4017340401734040192531914Escherichia coli SE11 chromosome, complete genomePTS system mannitol-specific IIABC components3e-27120
NC_015224:4473230:4473230447323044750951866Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,PTS system, mannitol-specific IIABC component5e-26116
NC_012121:1676367:167840716784071678841435Staphylococcus carnosus subsp. carnosus TM300, complete genomePTS system, mannitol-specific IIA component1e-24111
NC_009004:25988:303583035830789432Lactococcus lactis subsp. cremoris MG1363, complete genomePTS system, mannitol-specific IIA component4e-23106
NC_002662:30922:329073290733338432Lactococcus lactis subsp. lactis Il1403, complete genomemannitol-specific PTS system IIA component1e-22105
NC_010465:3046904:3049554304955430506871134Yersinia pseudotuberculosis YPIII, complete genomephosphocarrier, HPr family2e-21101
NC_005810:1413305:1415955141595514170881134Yersinia pestis biovar Microtus str. 91001, complete genomebifunctional fructose-specific PTS IIA/HPr protein2e-21101
NC_010634:1565788:1581587158158715827201134Yersinia pseudotuberculosis PB1/+, complete genomeHPr family phosphocarrier protein2e-21101
NC_008149:3022970:3025620302562030267531134Yersinia pestis Nepal516, complete genomehypothetical protein2e-21101
NC_010159:1558000:1573109157310915742421134Yersinia pestis Angola, complete genomephosphocarrier, HPr family2e-21101
NC_003143:1441211:1456994145699414581271134Yersinia pestis CO92, complete genomehypothetical protein2e-21101
NC_006155:1567306:1583090158309015842231134Yersinia pseudotuberculosis IP 32953, complete genomePTS system, fructose-specific II component / phosphocarrier p...2e-21101
NC_008150:1147883:1163094116309411642271134Yersinia pestis Antiqua, complete genomehypothetical protein2e-21101
NC_004088:3186954:3189604318960431907371134Yersinia pestis KIM, complete genomePTS system, fructose-specific IIA/fpr component2e-21101
NC_009381:2731965:2734615273461527357481134Yersinia pestis Pestoides F chromosome, complete genomebifunctional PTS system fructose-specific transporter subunit IIA/HPr protein2e-21101
NC_014029:1512605:1528380152838015295131134Yersinia pestis Z176003 chromosome, complete genomehypothetical protein2e-21101
NC_017154:1454704:1470488147048814716211134Yersinia pestis D106004 chromosome, complete genomehypothetical protein2e-21101
NC_017160:1299733:1302191130219113033241134Yersinia pestis D182038 chromosome, complete genomehypothetical protein2e-21101
NC_017168:4363000:4379062437906243801951134Yersinia pestis A1122 chromosome, complete genomebifunctional PTS system fructose-specific transporter subunit IIA/HPr protein2e-21101
NC_017265:2807302:2809952280995228110851134Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,IIA and HPr components of fructose-specific PTS enzyme2e-21101
NC_016513:317197:3400363400363415651530Aggregatibacter actinomycetemcomitans ANH9381 chromosome, completebifunctional PTS system fructose-specific transporter subunit IIA/HPr protein2e-21100
NC_014121:3553809:3554507355450735556371131Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completebifunctional fructose-specific PTS IIA/HPr protein2e-21100
NC_009708:3035798:3038448303844830395811134Yersinia pseudotuberculosis IP 31758 chromosome, complete genomebifunctional PTS system fructose-specific transporter subunit IIA/HPr protein2e-21100
NC_013172:783097:8049728049728070352064Brachybacterium faecium DSM 4810, complete genomephosphotransferase system, mannitol-specific IIBC component9e-2198.6
NC_020995:2636519:2645125264512526470441920Enterococcus casseliflavus EC20, complete genomehypothetical protein2e-2097.4
NC_012526:2483000:2505755250575525082382484Deinococcus deserti VCD115, complete genomeputative phosphoenolpyruvate-protein phosphotransferase5e-1993.2
NC_005955:173436:1734361734361759492514Bartonella quintana str. Toulouse, complete genomeMultiphosphoryl transfer protein (mtp)3e-1580.9
NC_015224:1914833:192682219268221927253432Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,phosphoenolpyruvate-dependent sugar phosphotransferase system, IIA component5e-1476.3
NC_014306:1286248:130376113037611304192432Erwinia billingiae Eb661, complete genomephosphoenolpyruvate-dependent sugar phosphotransferase system, IIa component1e-1375.1
NC_020829:1068438:1091157109115710940362880Pseudomonas denitrificans ATCC 13867, complete genomemulitfunctional PTS system fructose-like transporter subunit IIA/phosphocarrier protein HPr/phosphoenolpyruvate-protein phosphotransferase2e-1167.8
NC_015565:2827444:284287628428762843328453Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeputative PTS IIA-like nitrogen-regulatory protein PtsN9e-1165.5
NC_014377:532816:5535915535915554221832Thermosediminibacter oceani DSM 16646 chromosome, complete genome1e-1065.1
NC_014448:225414:224984224984225421438Mycoplasma hyorhinis HUB-1 chromosome, complete genomeMannitol-specific phosphotransferase enzyme IIA component2e-1064.3
NC_016894:377446:3791203791203810301911Acetobacterium woodii DSM 1030 chromosome, complete genomefructose-specific PTS system II components ABC1e-0962
NC_011660:2175537:219569621956962196160465Listeria monocytogenes HCC23 chromosome, complete genomeiiabc fructose/xylitol-pts4e-0960.1
NC_013642:942767:970308970308970760453Thermotoga naphthophila RKU-10, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN7e-0959.3
NC_013517:1849912:1857393185739318594892097Sebaldella termitidis ATCC 33386, complete genometranscriptional antiterminator, BglG7e-0959.3
NC_010483:642577:649497649497649949453Thermotoga sp. RQ2, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN6e-0959.3
NC_010468:1816359:182091418209141821372459Escherichia coli ATCC 8739, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN8e-0958.9
NC_013199:392450:4054264054264073691944Lactobacillus rhamnosus Lc 705, complete genomePTS system, fructose-specific IIABC component (fruA-2)1e-0858.5
NC_015391:2449927:245398724539872454439453Carnobacterium sp. 17-4 chromosome, complete genomePTS system mannose-specific EIIBCA component2e-0858.2
NC_015687:250768:264280264280264723444Clostridium acetobutylicum DSM 1731 chromosome, complete genomePTS system, IIA component2e-0857.8
NC_003030:249648:264282264282264725444Clostridium acetobutylicum ATCC 824, complete genomePTS system, IIA component2e-0857.8
NC_005362:1796696:1806355180635518083401986Lactobacillus johnsonii NCC 533, complete genomephosphoenolpyruvate-dependent sugar phosphotransferase system EIIABC, probable fructose specific2e-0857.8
NC_013198:394000:412099412099412572474Lactobacillus rhamnosus GG, complete genomePTS system, fructose-specific IIA component3e-0857.4
NC_011083:3171171:318477431847743185232459Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,pts system mannitol-specific eiicba component3e-0857.4
NC_009437:2579161:258256325825632583012450Caldicellulosiruptor saccharolyticus DSM 8903, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN2e-0857.4
NC_006510:2044347:2064172206417220662262055Geobacillus kaustophilus HTA426, complete genomehypothetical protein5e-0856.2
NC_009617:648000:651641651641652087447Clostridium beijerinckii NCIMB 8052 chromosome, complete genomePTS transporter subunit IIA-like nitrogen-regulatory protein PtsN8e-0855.8
NC_012731:2650603:266458026645802665017438Klebsiella pneumoniae NTUH-K2044 chromosome, complete genomeascorbate-specific PTS family enzyme IIA component1e-0755.5
NC_016845:2691129:270512727051272705564438Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome,PTS system protein2e-0754.7
NC_014328:2872721:288955228895522889989438Clostridium ljungdahlii ATCC 49587 chromosome, complete genomePTS system fructose/mannose-specific transporter subunit IIA2e-0754.3
NC_011969:4945441:4961027496102749629731947Bacillus cereus Q1 chromosome, complete genomemanr2e-0754.3
NC_014335:3461115:3471548347154834732601713Bacillus cereus biovar anthracis str. CI chromosome, completePTS fructose-specific enzyme IIBC component3e-0753.9
NC_004431:279868:307515307515307958444Escherichia coli CFT073, complete genomePTS system, mannitol (Cryptic)-specific IIA component3e-0753.9
NC_003909:3483244:3494145349414534960011857Bacillus cereus ATCC 10987, complete genomePTS system, fructose-specific IIABC component3e-0753.9
NC_009648:1914621:192860019286001929037438Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomePTS family enzyme IIA, mannitol-specific, cryptic4e-0753.5
NC_016779:4969626:4983899498389949858451947Bacillus cereus F837/76 chromosome, complete genomeBglG family transcriptional antiterminator4e-0753.5
NC_002570:207555:209185209185209667483Bacillus halodurans C-125, complete genomePTS system, galactitol-specific enzyme II, A component4e-0753.5
NC_012581:709234:7175947175947194741881Bacillus anthracis str. CDC 684 chromosome, complete genomePTS system fructose-specific transporter subunit IIABC4e-0753.5
NC_011773:3547507:3558350355835035602061857Bacillus cereus AH820 chromosome, complete genomePTS system fructose-specific transporter subunit IIABC4e-0753.1
NC_015214:1853106:1874088187408818760912004Lactobacillus acidophilus 30SC chromosome, complete genomePTS system, fructose-specific enzyme II5e-0753.1
NC_008600:5005345:5019631501963150215861956Bacillus thuringiensis str. Al Hakam, complete genometranscriptional regulator5e-0753.1
NC_019908:1512622:153162015316201532084465Brachyspira pilosicoli P43/6/78 chromosome, complete genomePTS system fructose subfamily transporter subunit IIC6e-0752.8
NC_013515:347671:372227372227372685459Streptobacillus moniliformis DSM 12112, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN1e-0652
NC_015731:990000:991959991959992426468Nitrosomonas sp. Is79A3 chromosome, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN1e-0652
NC_012781:4065:1960719607215351929Eubacterium rectale ATCC 33656, complete genomePTS system, fructose-specific, IIABC component1e-0651.6
NC_010842:2919108:293816229381622938623462Leptospira biflexa serovar Patoc strain 'Patoc 1 (Ames)' chromosomeProtein-N(pi)-phosphohistidine-sugar phosphotransferase, subunit A2e-0651.2
NC_010602:2911823:292977629297762930237462Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'PTS system, IIA component2e-0651.2
NC_014334:369974:3873613873613893491989Lactobacillus casei str. Zhang chromosome, complete genomePTS system fructose-specific transporter subunit IIABC3e-0650.8
NC_015152:2887414:290229129022912902737447Spirochaeta sp. Buddy chromosome, complete genomePTS IIA-like nitrogen-regulatory protein PtsN2e-0650.8
NC_015663:4447984:446152744615274461967441Enterobacter aerogenes KCTC 2190 chromosome, complete genomePTS IIA-like nitrogen-regulatory protein PtsN2e-0650.8
NC_013956:2592378:2594311259431125962181908Pantoea ananatis LMG 20103 chromosome, complete genomeLicR3e-0650.4
NC_003210:2879906:288296328829632883409447Listeria monocytogenes EGD-e, complete genomehypothetical protein3e-0650.4
NC_019842:2575000:2590378259037825923361959Bacillus amyloliquefaciens subsp. plantarum AS43.3 chromosome,PTS system mannose-specific transporter subunits IIBCA3e-0650.4
NC_009617:234782:2490212490212519452925Clostridium beijerinckii NCIMB 8052 chromosome, complete genomesigma-54 factor interaction domain-containing protein3e-0650.4
NC_009725:2517428:2536355253635525383131959Bacillus amyloliquefaciens FZB42, complete genomeManP3e-0650.4
NC_020181:969599:975124975124975564441Enterobacter aerogenes EA1509E, complete genomePTS system, IIA component5e-0650.1
NC_012472:5015621:5029907502990750318531947Bacillus cereus 03BB102, complete genometranscriptional regulator4e-0650.1
NC_014624:1675500:175846817584681758923456Eubacterium limosum KIST612 chromosome, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN4e-0650.1
NC_017191:2514401:2531358253135825333101953Bacillus amyloliquefaciens XH7 chromosome, complete genomemannose operon transcriptional antiterminator7e-0649.3
NC_017188:2512357:2529314252931425312661953Bacillus amyloliquefaciens TA208 chromosome, complete genometranscriptional antiterminator7e-0649.3
NC_013850:2685835:269143426914342691871438Klebsiella variicola At-22 chromosome, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN7e-0649.3