Pre_GI: BLASTP Hits

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Query: NC_017179:2513804:2533225 Clostridium difficile BI1, complete genome

Start: 2533225, End: 2534376, Length: 1152

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:2505792:2525213252521325263641152Clostridium difficile CD196 chromosome, complete genomemannitol-1-phosphate 5-dehydrogenase0768
NC_013316:2585666:2605769260576926069201152Clostridium difficile R20291, complete genomemannitol-1-phosphate 5-dehydrogenase0768
NC_009617:263060:2807002807002818451146Clostridium beijerinckii NCIMB 8052 chromosome, complete genomemannitol dehydrogenase domain-containing protein5e-154544
NC_012967:3696877:3709117370911737102651149Escherichia coli B str. REL606 chromosome, complete genomemannitol-1-phosphate 5-dehydrogenase1e-109396
NC_012947:126596:1341721341721353201149Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completemannitol-1-phosphate 5-dehydrogenase1e-109396
NC_010498:3988351:4009933400993340110811149Escherichia coli SMS-3-5, complete genomemannitol-1-phosphate 5-dehydrogenase1e-109396
NC_012759:3648500:3660773366077336619211149Escherichia coli BW2952 chromosome, complete genomemannitol-1-phosphate 5-dehydrogenase3e-109395
NC_009800:3787320:3800954380095438021021149Escherichia coli HS, complete genomemannitol-1-phosphate 5-dehydrogenase7e-109394
CP002516:119935:1275111275111286591149Escherichia coli KO11, complete genomeMannitol dehydrogenase domain protein1e-108393
CU928145:4131924:4146314414631441474621149Escherichia coli 55989 chromosome, complete genomemannitol-1-phosphate dehydrogenase, NAD(P)-binding1e-108393
NC_004337:3590323:3740318374031837414661149Shigella flexneri 2a str. 301, complete genomemannitol-1-phosphate 5-dehydrogenase1e-108393
NC_009801:4073968:4087451408745140885991149Escherichia coli E24377A, complete genomemannitol-1-phosphate 5-dehydrogenase1e-108393
NC_011748:4131924:4146314414631441474621149Escherichia coli 55989, complete genomemannitol-1-phosphate 5-dehydrogenase1e-108393
CP002185:3964500:3977414397741439785621149Escherichia coli W, complete genomemannitol-1-phosphate dehydrogenase, NAD(P)-binding protein1e-108393
NC_011415:4006500:4019483401948340206311149Escherichia coli SE11 chromosome, complete genomemannitol-1-phosphate 5-dehydrogenase1e-108393
NC_016902:119935:1275111275111286591149Escherichia coli KO11FL chromosome, complete genomemannitol dehydrogenase domain-containing protein1e-108393
NC_010468:111504:1192541192541204021149Escherichia coli ATCC 8739, complete genomeMannitol dehydrogenase domain1e-108393
AP010958:4707712:4708299470829947094471149Escherichia coli O103:H2 str. 12009 DNA, complete genomemannitol-1-phosphate dehydrogenase MtlD, NAD(P)-binding1e-108393
NC_013353:4707712:4708299470829947094471149Escherichia coli O103:H2 str. 12009, complete genomemannitol-1-phosphate 5-dehydrogenase1e-108393
NC_009778:3832000:3832022383202238331701149Enterobacter sakazakii ATCC BAA-894, complete genomehypothetical protein8e-106384
NC_013282:116649:1318321318321329801149Cronobacter turicensis, complete genomeMannitol-1-phosphate 5-dehydrogenase6e-106384
NC_020260:3836500:3836619383661938377671149Cronobacter sakazakii Sp291, complete genomemannitol-1-phosphate 5-dehydrogenase4e-105381
NC_013416:1748848:1750450175045017515981149Aggregatibacter actinomycetemcomitans D11S-1, complete genomemannitol-1-phosphate 5-dehydrogenase2e-95349
NC_016513:2103958:2104545210454521056931149Aggregatibacter actinomycetemcomitans ANH9381 chromosome, completemannitol-1-phosphate 5-dehydrogenase3e-95348
NC_009004:25988:3093830938321041167Lactococcus lactis subsp. cremoris MG1363, complete genomemannitol-1-phosphate 5-dehydrogenase3e-71269
NC_002662:30922:3347633476346331158Lactococcus lactis subsp. lactis Il1403, complete genomemannitol-1-phosphate 5-dehydrogenase8e-71267
NC_017341:2303005:2307156230715623082621107Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,putative mannitol-1-phosphate 5-dehydrogenase6e-67254
NC_002951:2208813:2212964221296422140701107Staphylococcus aureus subsp. aureus COL, complete genomemannitol-1-phosphate 5-dehydrogenase6e-67254
NC_020207:1346579:1346579134657913477181140Enterococcus faecium NRRL B-2354, complete genomeMannitol-1-phosphate 5-dehydrogenase8e-67254
NC_012121:1676367:1678841167884116799441104Staphylococcus carnosus subsp. carnosus TM300, complete genomemannitol-1-phosphate 5-dehydrogenase1e-65250
NC_013172:783097:8038258038258049641140Brachybacterium faecium DSM 4810, complete genomeD-mannitol 1-phosphate 5-dehydrogenase2e-62239
NC_015389:616430:6684716684716696581188Coriobacterium glomerans PW2 chromosome, complete genomeMannitol-1-phosphate 5-dehydrogenase4e-56218
NC_015732:140087:1526251526251538421218Spirochaeta caldaria DSM 7334 chromosome, complete genomeMannitol-1-phosphate 5-dehydrogenase6e-40165
NC_014448:225414:2254142254142265141101Mycoplasma hyorhinis HUB-1 chromosome, complete genomeMannitol-1-phosphate 5-dehyrogenase2e-28126
NC_020995:2636519:2643953264395326451131161Enterococcus casseliflavus EC20, complete genomehypothetical protein1e-20101
NC_014121:3553809:3570016357001635714821467Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completefructuronate reductase1e-1997.8
NC_012880:1091486:1114655111465511161481494Dickeya dadantii Ech703, complete genomeMannitol dehydrogenase domain protein3e-1996.3
NC_012947:2189533:2202173220217322036331461Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completemannitol dehydrogenase7e-1788.6
NC_012967:1593101:1597220159722015986801461Escherichia coli B str. REL606 chromosome, complete genomeputative mannonate dehydrogenase7e-1788.6
NC_002655:1909139:1931661193166119331211461Escherichia coli O157:H7 EDL933, complete genomeputative oxidoreductase9e-1788.2
CP002185:1727493:1748392174839217498521461Escherichia coli W, complete genomepredicted mannonate dehydrogenase1e-1687.4
CP002185:4791811:4815342481534248168021461Escherichia coli W, complete genomeD-mannonate oxidoreductase, NAD-binding protein2e-1687.4
NC_010473:1712984:1717102171710217185621461Escherichia coli str. K-12 substr. DH10B, complete genomepredicted mannonate dehydrogenase3e-1686.7
AC_000091:1627049:1631167163116716326271461Escherichia coli W3110 DNA, complete genomepredicted mannonate dehydrogenase3e-1686.7
NC_000913:1625500:1627477162747716289371461Escherichia coli K12, complete genomepredicted mannonate dehydrogenase3e-1686.7
NC_012759:1517500:1519536151953615209961461Escherichia coli BW2952 chromosome, complete genomeputative mannonate dehydrogenase3e-1686.7
NC_011741:1625535:1646434164643416478941461Escherichia coli IAI1 chromosome, complete genomeputative mannonate dehydrogenase5e-1685.9
CU928160:1625535:1646434164643416478941461Escherichia coli IAI1 chromosome, complete genomeputative mannonate dehydrogenase5e-1685.9
NC_007613:4403070:4426847442684744283071461Shigella boydii Sb227, complete genomeD-mannonate oxidoreductase6e-1685.5
NC_011415:1715644:1736543173654317380031461Escherichia coli SE11 chromosome, complete genomeputative oxidoreductase9e-1684.7
NC_008563:1651270:1672665167266516741251461Escherichia coli APEC O1, complete genomeputative oxidoreductase1e-1584.7
NC_012967:4510393:4533815453381545352751461Escherichia coli B str. REL606 chromosome, complete genomeD-mannonate oxidoreductase2e-1583.6
NC_000913:4528278:4550924455092445523841461Escherichia coli K12, complete genomeD-mannonate oxidoreductase, NAD-binding3e-1583.2
AC_000091:4534935:4557581455758145590411461Escherichia coli W3110 DNA, complete genomeD-mannonate oxidoreductase, NAD-binding3e-1583.2
NC_004431:5123325:5147630514763051490901461Escherichia coli CFT073, complete genomeD-mannonate oxidoreductase4e-1582.8
NC_014934:2985273:2987797298779729892931497Cellulophaga algicola DSM 14237 chromosome, complete genomemannitol 2-dehydrogenase4e-1582.8
NC_008253:4817864:4856941485694148584011461Escherichia coli 536, complete genomeD-mannonate oxidoreductase4e-1582.8
CU928160:4570498:4613543461354346150031461Escherichia coli IAI1 chromosome, complete genomeD-mannonate oxidoreductase, NAD-binding4e-1582.8
NC_011741:4570498:4613543461354346150031461Escherichia coli IAI1 chromosome, complete genomeD-mannonate oxidoreductase, NAD-binding4e-1582.8
NC_011745:5114500:5135097513509751365571461Escherichia coli ED1a chromosome, complete genomeD-mannonate oxidoreductase, NAD-binding4e-1582.8
NC_007946:4875997:4916451491645149179111461Escherichia coli UTI89, complete genomeD-mannonate oxidoreductase6e-1582
NC_011283:2836000:2913469291346929149321464Klebsiella pneumoniae 342 chromosome, complete genomemannitol dehydrogenase1e-1480.9
NC_017262:1913302:1926938192693819284491512Zymomonas mobilis subsp. mobilis ATCC 10988 chromosome, completeMannitol dehydrogenase domain-containing protein2e-1480.9
NC_013850:2846069:2875837287583728773001464Klebsiella variicola At-22 chromosome, complete genomeMannitol dehydrogenase domain protein2e-1480.5
NC_015761:2982000:3003258300325830047301473Salmonella bongori NCTC 12419, complete genomeD-mannonate oxidoreductase3e-1480.1
NC_002944:4254011:4256240425624042576431404Mycobacterium avium subsp. paratuberculosis K-10, complete genomehypothetical protein5e-1479
NC_008149:3022970:3043105304310530445771473Yersinia pestis Nepal516, complete genomeD-mannonate oxidoreductase2e-1377.4
NC_004088:3186954:3207097320709732085691473Yersinia pestis KIM, complete genomeoxidoreductase2e-1377.4
NC_017265:2807302:2827446282744628289181473Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,putative D-mannonate oxidoreductase2e-1377.4
NC_005810:1413305:1433444143344414349161473Yersinia pestis biovar Microtus str. 91001, complete genomeputative D-mannonate oxidoreductase1e-1377.4
NC_010465:3046904:3067079306707930685511473Yersinia pseudotuberculosis YPIII, complete genomeMannitol dehydrogenase domain1e-1377.4
NC_009381:2731965:2752118275211827535901473Yersinia pestis Pestoides F chromosome, complete genomeD-mannonate oxidoreductase1e-1377.4
NC_009708:3035798:3056001305600130574731473Yersinia pseudotuberculosis IP 31758 chromosome, complete genomemannitol dehydrogenase family protein1e-1377.4
NC_017160:1299733:1319692131969213208911200Yersinia pestis D182038 chromosome, complete genomeD-mannonate oxidoreductase1e-1274.7
NC_014532:1713987:1734756173475617362311476Halomonas elongata DSM 2581, complete genomeK00045 mannitol 2-dehydrogenase6e-1272.4
NC_018644:516157:5208635208635223591497Alpha proteobacterium HIMB59 chromosome, complete genomemannitol dehydrogenase family protein,long chain polyol dehydrogenase7e-1272
NC_008027:2051821:2067299206729920687741476Pseudomonas entomophila L48, complete genomemannitol dehydrogenase8e-1271.6
NC_014934:2985273:2990241299024129917311491Cellulophaga algicola DSM 14237 chromosome, complete genomemannitol 2-dehydrogenase1e-1171.2
NC_007492:2994036:3017276301727630187481473Pseudomonas fluorescens PfO-1, complete genomeMannitol dehydrogenase1e-1170.9
NC_015588:475723:4957584957584972961539Isoptericola variabilis 225 chromosome, complete genomeFructuronate reductase2e-1170.5
NC_013421:57961:6907769077705221446Pectobacterium wasabiae WPP163, complete genomeMannitol dehydrogenase domain protein6e-1168.9
NC_003911:1791878:1842948184294818444321485Silicibacter pomeroyi DSS-3, complete genomeD-mannonate oxidoreductase8e-1168.6
NC_014041:3197192:3199936319993632013781443Zunongwangia profunda SM-A87 chromosome, complete genometagaturonate reductase3e-1066.6
NC_013174:2564979:2575215257521525766631449Jonesia denitrificans DSM 20603, complete genomemannitol dehydrogenase domain protein9e-1065.1
NC_009256:2945059:2990232299023229916261395Burkholderia vietnamiensis G4 chromosome 1, complete sequencemannitol dehydrogenase domain-containing protein1e-0964.7
NC_016902:2361628:2382984238298423844351452Escherichia coli KO11FL chromosome, complete genomemannitol dehydrogenase domain-containing protein1e-0964.7
CP002516:2361628:2382984238298423844351452Escherichia coli KO11, complete genomeMannitol dehydrogenase domain protein1e-0964.7
NC_011742:1574036:1594881159488115963321452Escherichia coli S88 chromosome, complete genomealtronate oxidoreductase1e-0964.7
NC_013961:3709800:3724496372449637258991404Erwinia amylovora, complete genomeputative mannitol dehydrogenase2e-0963.9
NC_013971:3713000:3724754372475437261571404Erwinia amylovora ATCC 49946 chromosome, complete genomeD-arabinitol 4-dehydrogenase2e-0963.9
NC_009142:5519208:5519208551920855206831476Saccharopolyspora erythraea NRRL 2338, complete genomefructuronate reductase2e-0963.9
NC_013757:1343396:1345338134533813469241587Geodermatophilus obscurus DSM 43160, complete genomeMannitol dehydrogenase domain protein2e-0963.5
CP002797:1591000:1607849160784916093001452Escherichia coli NA114, complete genomeAltronate oxidoreductase2e-0963.5
NC_008786:3915000:3936210393621039377391530Verminephrobacter eiseniae EF01-2, complete genomeMannitol dehydrogenase, C-terminal domain2e-0963.5
NC_013716:1618249:1618249161824916197001452Citrobacter rodentium ICC168, complete genomealtronate oxidoreductase2e-0963.5
NC_009792:1479779:1493766149376614952171452Citrobacter koseri ATCC BAA-895, complete genomehypothetical protein3e-0963.2
NC_008253:1534840:1554668155466815561191452Escherichia coli 536, complete genomealtronate oxidoreductase3e-0963.2
NC_015856:1271295:1284268128426812856771410Collimonas fungivorans Ter331 chromosome, complete genomeD-arabinitol 4-dehydrogenase4e-0962.8
NC_015224:3892972:3931552393155239330031452Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,altronate oxidoreductase8e-0961.6
NC_012214:3931824:3946439394643939478421404Erwinia pyrifoliae Ep1/96, complete genomeD-arabinitol 4-dehydrogenase1e-0861.2
NC_015145:1045264:1082780108278010842521473Arthrobacter phenanthrenivorans Sphe3 chromosome, complete genomemannitol-1-phosphate/altronate dehydrogenase2e-0860.8
NC_015172:1195782:1195782119578211979802199Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeHAD-superfamily hydrolase, subfamily IA, variant 36e-0755.8