Pre_GI: BLASTP Hits

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Query: NC_017179:2513804:2532263 Clostridium difficile BI1, complete genome

Start: 2532263, End: 2532835, Length: 573

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:2505792:252425125242512524823573Clostridium difficile CD196 chromosome, complete genomexanthine phosphoribosyltransferase8e-103372
NC_013316:2585666:260480726048072605379573Clostridium difficile R20291, complete genomexanthine phosphoribosyltransferase8e-103372
NC_012563:1348500:135361513536151354187573Clostridium botulinum A2 str. Kyoto, complete genomexanthine phosphoribosyltransferase1e-60232
NC_017297:1280963:128425812842581284836579Clostridium botulinum F str. 230613 chromosome, complete genomexanthine phosphoribosyltransferase3e-60231
NC_021182:1654903:165683716568371657409573Clostridium pasteurianum BC1, complete genomexanthine phosphoribosyltransferase1e-58225
NC_018664:1279950:129176012917601292335576Clostridium acidurici 9a chromosome, complete genomexanthine phosphoribosyltransferase Xpt6e-58223
NC_010001:4128034:412803441280344128618585Clostridium phytofermentans ISDg, complete genomexanthine phosphoribosyltransferase3e-52204
NC_018720:1186058:118931611893161189906591Bifidobacterium asteroides PRL2011 chromosome, complete genomexanthine phosphoribosyltransferase2e-51201
NC_015738:2773552:279034627903462790921576Eggerthella sp. YY7918, complete genomeadenine/guanine phosphoribosyltransferase6e-49193
NC_013410:2037840:204231820423182042899582Fibrobacter succinogenes subsp. succinogenes S85 chromosome,xanthine phosphoribosyltransferase3e-48191
NC_010337:1445512:146659614665961467162567Heliobacterium modesticaldum Ice1, complete genomexanthine phosphoribosyltransferase8e-47186
NC_020829:5382500:540188754018875402462576Pseudomonas denitrificans ATCC 13867, complete genomexanthine phosphoribosyltransferase5e-45180
NC_017068:130226:141654141654142229576Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative Xanthine phosphoribosyltransferase1e-42172
NC_014033:675626:685510685510686088579Prevotella ruminicola 23 chromosome, complete genomexanthine phosphoribosyltransferase1e-42172
NC_014622:5553628:556722855672285568022795Paenibacillus polymyxa SC2 chromosome, complete genomeadenine/guanine phosphoribosyltransferase5e-42170
NC_020209:4549563:457375345737534574322570Pseudomonas poae RE*1-1-14, complete genomexanthine phosphoribosyltransferase2e-41168
NC_017188:1172181:117718811771881177772585Bacillus amyloliquefaciens TA208 chromosome, complete genomexanthine phosphoribosyltransferase6e-41166
NC_017190:2130651:227971522797152280299585Bacillus amyloliquefaciens LL3 chromosome, complete genomexanthine phosphoribosyltransferase6e-41166
NC_017191:1173989:117876511787651179349585Bacillus amyloliquefaciens XH7 chromosome, complete genomexanthine phosphoribosyltransferase6e-41166
NC_014106:244831:246124246124246702579Lactobacillus crispatus ST1, complete genomeXanthine phosphoribosyltransferase2e-38158
NC_009615:1734752:175252817525281753094567Parabacteroides distasonis ATCC 8503 chromosome, complete genomexanthine phosphoribosyltransferase8e-36149
NC_013171:416279:431048431048431626579Anaerococcus prevotii DSM 20548, complete genomexanthine phosphoribosyltransferase3e-35147
NC_008054:245184:250831250831251400570Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, completeXanthine phosphoribosyltransferase1e-30132
NC_009633:168266:171020171020171841822Alkaliphilus metalliredigens QYMF chromosome, complete genomepur operon repressor1e-0859.7
NC_013520:718732:734190734190735008819Veillonella parvula DSM 2008, complete genomepurine operon repressor, PurR1e-0859.7
NC_012121:139741:148189148189149013825Staphylococcus carnosus subsp. carnosus TM300, complete genomepur operon repressor2e-0858.5
NC_019978:91483:967949679497618825Halobacteroides halobius DSM 5150, complete genomepur operon repressor4e-0857.8
NC_017297:3878540:389411438941143894929816Clostridium botulinum F str. 230613 chromosome, complete genomepur operon repressor6e-0857.4
NC_009698:3647955:366621036662103667025816Clostridium botulinum A str. Hall chromosome, complete genomepur operon repressor6e-0857.4
NC_009697:3753527:376910037691003769915816Clostridium botulinum A str. ATCC 19397 chromosome, completepur operon repressor6e-0857.4
NC_010516:3845942:386424838642483865063816Clostridium botulinum B1 str. Okra, complete genomepur operon repressor6e-0857.4
NC_000961:1481685:148646414864641487234771Pyrococcus horikoshii OT3, complete genomeadenine phosphoribosyltransferase2e-0652
NC_013061:987744:988646988646989173528Pedobacter heparinus DSM 2366, complete genomeadenine phosphoribosyltransferase3e-0651.6
NC_007955:1498777:151533515153351515907573Methanococcoides burtonii DSM 6242, complete genomephosphoribosyltransferase8e-0650.1