Pre_GI: BLASTP Hits

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Query: NC_017179:2513804:2527426 Clostridium difficile BI1, complete genome

Start: 2527426, End: 2527884, Length: 459

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:2505792:251941425194142519872459Clostridium difficile CD196 chromosome, complete genomePTS system galactitol-specific transporter subunit IIA1e-83308
NC_013316:2585666:259997025999702600428459Clostridium difficile R20291, complete genomePTS system, galactitol-specific IIa component1e-83308
NC_009617:234782:252039252039252506468Clostridium beijerinckii NCIMB 8052 chromosome, complete genomePTS transporter subunit IIA-like nitrogen-regulatory protein PtsN8e-35145
NC_003212:2814737:283133828313382831802465Listeria innocua Clip11262, complete genomehypothetical protein3e-30130
NC_003210:2721559:274039027403902740854465Listeria monocytogenes EGD-e, complete genomehypothetical protein3e-30130
NC_014377:1400544:141148014114801411953474Thermosediminibacter oceani DSM 16646 chromosome, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN6e-30129
NC_008555:2628858:264543226454322645899468Listeria welshimeri serovar 6b str. SLCC5334, complete genomePTS system, IIA component7e-29125
NC_009617:648000:651641651641652087447Clostridium beijerinckii NCIMB 8052 chromosome, complete genomePTS transporter subunit IIA-like nitrogen-regulatory protein PtsN1e-25115
NC_014363:8228:170481704817506459Olsenella uli DSM 7084 chromosome, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN1e-21102
NC_021182:3771523:378625237862523786719468Clostridium pasteurianum BC1, complete genomephosphotransferase system mannitol/fructose-specifc IIA component (Ntr-type)3e-21100
NC_014650:2417509:242881224288122429279468Geobacillus sp. Y4.1MC1 chromosome, complete genomePTS IIA-like nitrogen-regulatory protein PtsN3e-1994
NC_011083:3985618:399815739981573998630474Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,putative phosphoenolpyruvate-dependent sugar phosphotransferase system, eiia 24e-1993.6
NC_011094:3853036:386566038656603866133474Salmonella enterica subsp. enterica serovar Schwarzengrund strphosphotransferase system mannitol/fructose-specific IIA domain6e-1992.8
NC_006511:3759550:377208037720803772553474Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCChypothetical protein6e-1992.8
NC_006905:3913988:392361539236153924088474Salmonella enterica subsp. enterica serovar Choleraesuis strputative phosphotransferase system mannitol/fructose-specific IIA domain6e-1992.8
NC_003197:3971905:398394839839483984421474Salmonella typhimurium LT2, complete genomeputative phosphotransferase system mannitol/fructose-specific IIA domain6e-1992.8
NC_011149:3895921:390846039084603908933474Salmonella enterica subsp. enterica serovar Agona str. SL483,putative phosphoenolpyruvate-dependent sugar phosphotransferase system, eiia 26e-1992.8
NC_011080:3941909:395453239545323955005474Salmonella enterica subsp. enterica serovar Newport str. SL254,putative phosphotransferase system mannitol/fructose-specific IIA domain6e-1992.8
NC_010102:3919999:393204239320423932515474Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein6e-1992.8
NC_011147:3755725:376775937677593768232474Salmonella enterica subsp. enterica serovar Paratyphi A strhypothetical protein6e-1992.8
NC_012125:3905782:391840539184053918878474Salmonella enterica subsp. enterica serovar Paratyphi C strainphosphotransferase system mannitol/fructose-specific IIA domain protein6e-1992.8
NC_017046:3991551:400408940040894004562474Salmonella enterica subsp. enterica serovar Typhimurium str. 798phosphoenolpyruvate-dependent sugar phosphotransferase system, eiia 26e-1992.8
NC_016863:3933848:394524739452473945720474Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1phosphotransferase system mannitol/fructose-specific IIA component6e-1992.8
NC_016860:3995445:400684440068444007317474Salmonella enterica subsp. enterica serovar Typhimurium strputative PTS system EIIA protein6e-1992.8
NC_016857:3993864:400526240052624005735474Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74beta-lactamase6e-1992.8
NC_016856:3985597:399764039976403998113474Salmonella enterica subsp. enterica serovar Typhimurium str. 14028Sphosphotransferase system mannitol/fructose-specific IIA component6e-1992.8
NC_016810:3993863:400526140052614005734474Salmonella enterica subsp. enterica serovar Typhimurium strputative phosphoenolpyruvate-dependent sugar phosphotransferase system, eiia 26e-1992.8
NC_015389:616430:624292624292624759468Coriobacterium glomerans PW2 chromosome, complete genomePTS system IIA component, Gat family2e-1787.8
NC_002570:207555:209185209185209667483Bacillus halodurans C-125, complete genomePTS system, galactitol-specific enzyme II, A component9e-1785.9
NC_004631:3841975:384986538498653850245381Salmonella enterica subsp. enterica serovar Typhi Ty2, completehypothetical protein2e-1685.1
NC_003198:3855157:386437538643753864755381Salmonella enterica subsp. enterica serovar Typhi str. CT18,hypothetical protein2e-1685.1
NC_016516:15102:230572305723533477Propionibacterium acnes TypeIA2 P.acn33 chromosome, completePTS system galactitol-specific transporter subunit IIA3e-1580.9
NC_016512:15102:230572305723533477Propionibacterium acnes TypeIA2 P.acn17 chromosome, completePTS system galactitol-specific transporter subunit IIA3e-1580.9
NC_006085:15246:232012320123677477Propionibacterium acnes KPA171202, complete genomePTS system, galactitol-specific IIA component3e-1580.9
NC_016511:15100:230552305523531477Propionibacterium acnes TypeIA2 P.acn31 chromosome, completePTS system galactitol-specific transporter subunit IIA1e-1479
NC_014039:15236:231912319123667477Propionibacterium acnes SK137 chromosome, complete genomephosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 21e-1479
NC_013517:1849912:185962918596291860096468Sebaldella termitidis ATCC 33386, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN8e-1475.9
NC_014363:427393:435415435415435888474Olsenella uli DSM 7084 chromosome, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN1e-1375.5
NC_014377:532816:5535915535915554221832Thermosediminibacter oceani DSM 16646 chromosome, complete genome7e-1269.3
NC_014363:114239:126272126272126751480Olsenella uli DSM 7084 chromosome, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN1e-1168.6
NC_011083:3171171:318477431847743185232459Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,pts system mannitol-specific eiicba component1e-1168.6
NC_014624:1675500:175846817584681758923456Eubacterium limosum KIST612 chromosome, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN2e-1064.7
NC_012967:2105251:212795721279572128409453Escherichia coli B str. REL606 chromosome, complete genomePTS system galactitol-specific transporter subunit IIA2e-1064.3
NC_013008:2824511:284391328439132844365453Escherichia coli O157:H7 str. TW14359 chromosome, complete genomePTS system galactitol-specific transporter subunit IIA3e-1064.3
NC_004431:2444972:246463924646392465091453Escherichia coli CFT073, complete genomePTS system, galactitol-specific IIA component3e-1064.3
NC_008253:2198583:221517422151742215626453Escherichia coli 536, complete genomePTS system, galactitol-specific IIA component4e-1063.9
NC_010468:1816359:182091418209141821372459Escherichia coli ATCC 8739, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN7e-1062.8
NC_011083:3171171:318061431806143181093480Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,galactitol-specific phosphotransferase enzyme iia component7e-0959.7
NC_014618:3700640:370776437077643708213450Enterobacter cloacae SCF1 chromosome, complete genomePTS IIA-like nitrogen-regulatory protein PtsN9e-0959.3
NC_009328:3322802:3325601332560133275771977Geobacillus thermodenitrificans NG80-2 chromosome, complete genomephosphotransferase system, fructose-specific IIC component8e-0959.3
NC_004603:370320:3703203703203722721953Vibrio parahaemolyticus RIMD 2210633 chromosome I, completePTS system, mannitol-specific IIABC component2e-0858.2
NC_015565:2827444:284287628428762843328453Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeputative PTS IIA-like nitrogen-regulatory protein PtsN3e-0857.8
NC_013921:2293411:229819122981912298646456Thermoanaerobacter italicus Ab9 chromosome, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN5e-0856.6
NC_016894:377446:3791203791203810301911Acetobacterium woodii DSM 1030 chromosome, complete genomefructose-specific PTS system II components ABC9e-0855.8
NC_016818:3736213:375093737509373751419483Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, completephosphotransferase system mannitol/fructose-specifc IIA component (Ntr-type)9e-0855.8
NC_015687:250768:264280264280264723444Clostridium acetobutylicum DSM 1731 chromosome, complete genomePTS system, IIA component1e-0755.5
NC_003030:249648:264282264282264725444Clostridium acetobutylicum ATCC 824, complete genomePTS system, IIA component1e-0755.5
NC_017188:2512357:2529314252931425312661953Bacillus amyloliquefaciens TA208 chromosome, complete genometranscriptional antiterminator1e-0755.1
NC_017191:2514401:2531358253135825333101953Bacillus amyloliquefaciens XH7 chromosome, complete genomemannose operon transcriptional antiterminator1e-0755.1
NC_007712:2978000:298029729802972980752456Sodalis glossinidius str. 'morsitans', complete genomeputative PTS system galactitol-specific IIA component1e-0755.1
NC_011660:2175537:219569621956962196160465Listeria monocytogenes HCC23 chromosome, complete genomeiiabc fructose/xylitol-pts3e-0754.3
NC_010468:1816359:182503318250331825476444Escherichia coli ATCC 8739, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN3e-0753.9
NC_017047:3793000:380813438081343808616483Rahnella aquatilis HX2 chromosome, complete genomePTS system galactitol-specific transporter subunit IIA3e-0753.9
NC_015061:3725921:374348837434883743970483Rahnella sp. Y9602 chromosome, complete genomePTS IIA-like nitrogen-regulatory protein PtsN3e-0753.9
NC_019842:2575000:2592489259248925944411953Bacillus amyloliquefaciens subsp. plantarum AS43.3 chromosome,licABCH operon regulator4e-0753.9
NC_020272:1384525:1384525138452513864771953Bacillus amyloliquefaciens IT-45, complete genomeputative licABCH operon regulator4e-0753.9
NC_014654:1:259152591526364450Halanaerobium sp. 'sapolanicus' chromosome, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN4e-0753.5
NC_009725:2517428:2538466253846625404181953Bacillus amyloliquefaciens FZB42, complete genomeManR5e-0753.5
NC_007644:3229:145621456215026465Moorella thermoacetica ATCC 39073, complete genomeputative PTS IIA-like nitrogen-regulatory protein PtsN8e-0752.8
NC_017195:1230485:1247625124762512495711947Bacillus subtilis subsp. subtilis str. RO-NN-1 chromosome, completeHTH domain family9e-0752.4
NC_005362:1796696:1806355180635518083401986Lactobacillus johnsonii NCC 533, complete genomephosphoenolpyruvate-dependent sugar phosphotransferase system EIIABC, probable fructose specific2e-0651.6
NC_014976:3469395:3483227348322734851731947Bacillus subtilis BSn5 chromosome, complete genometranscriptional antiterminator2e-0651.2
NC_011969:4945441:4961027496102749629731947Bacillus cereus Q1 chromosome, complete genomemanr3e-0650.8
NC_015761:2373967:2399144239914424016392496Salmonella bongori NCTC 12419, complete genomephosphoenolpyruvate-protein phosphotransferase4e-0650.4
NC_015214:1853106:1874088187408818760912004Lactobacillus acidophilus 30SC chromosome, complete genomePTS system, fructose-specific enzyme II4e-0650.1
NC_016779:4969626:4983899498389949858451947Bacillus cereus F837/76 chromosome, complete genomeBglG family transcriptional antiterminator6e-0650.1
NC_013416:1748848:1751676175167617535561881Aggregatibacter actinomycetemcomitans D11S-1, complete genomePTS system, mannitol-specific IIC subunit8e-0649.3
NC_020244:1264500:1273750127375012756961947Bacillus subtilis XF-1, complete genometranscriptional regulator8e-0649.3