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Query: NC_017179:2513804:2513804 Clostridium difficile BI1, complete genome

Start: 2513804, End: 2514535, Length: 732

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:2505792:250579225057922506523732Clostridium difficile CD196 chromosome, complete genomehypothetical protein1e-140498
NC_013316:2585666:258634825863482587079732Clostridium difficile R20291, complete genomehypothetical protein1e-140498
NC_015589:2049328:205126520512652052020756Desulfotomaculum ruminis DSM 2154 chromosome, complete genomehypothetical protein3e-44178
NC_020409:1407857:143347714334771434202726Desulfovibrio piezophilus str. nov C1TLV30 chromosome, completehypothetical protein3e-45181
NC_013887:17160:238692386924576708Methanocaldococcus sp. FS406-22 chromosome, complete genomeprotein of unknown function DUF3645e-38157
NC_015416:1103900:110390011039001104661762Methanosaeta concilii GP-6 chromosome, complete genomehypothetical protein1e-39163
NC_014408:1193239:120694512069451207652708Methanothermobacter marburgensis str. Marburg chromosome, completehypothetical protein2e-31135
NC_000916:826614:839743839743840078336Methanothermobacter thermautotrophicus str. Delta H, completehypothetical protein7e-1167.8
NC_016048:1390463:141400214140021414760759Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein8e-58223
NC_014364:3707311:373511337351133735871759Spirochaeta smaragdinae DSM 11293 chromosome, complete genomehypothetical protein9e-71266
NC_018870:115982:157209157209157940732Thermacetogenium phaeum DSM 12270 chromosome, complete genomehypothetical protein7e-54210
NC_013522:1683326:168880916888091689564756Thermanaerovibrio acidaminovorans DSM 6589, complete genomehypothetical protein8e-66250
NC_013522:1683326:170184817018481702024177Thermanaerovibrio acidaminovorans DSM 6589, complete genome4e-1478.6