Pre_GI: BLASTP Hits

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Query: NC_017179:1378875:1394032 Clostridium difficile BI1, complete genome

Start: 1394032, End: 1394289, Length: 258

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:1370000:138425813842581384515258Clostridium difficile CD196 chromosome, complete genome30S ribosomal protein S151e-41168
NC_010170:1661915:166191516619151662184270Bordetella petrii, complete genome30S ribosomal protein S151e-28124
NC_014103:3985897:399264639926463992915270Bacillus megaterium DSM319 chromosome, complete genome30S ribosomal protein S152e-28124
NC_012121:897866:917887917887918156270Staphylococcus carnosus subsp. carnosus TM300, complete genome30S ribosomal protein S152e-27121
NC_019814:678404:696619696619696888270Candidatus Kinetoplastibacterium blastocrithidii (ex Strigomonassmall subunit ribosomal protein S153e-27120
NC_002952:1291444:130764013076401307909270Staphylococcus aureus subsp. aureus MRSA252, complete genome30S ribosomal protein S152e-27120
NC_009782:1327340:134353413435341343803270Staphylococcus aureus subsp. aureus Mu3, complete genome30Sribosomal protein S152e-27120
NC_014387:1175927:120448012044801204746267Butyrivibrio proteoclasticus B316 chromosome 1, complete genomeribosomal protein S15 RpsO2e-27120
NC_007622:1214629:123082512308251231094270Staphylococcus aureus RF122, complete genome30S ribosomal protein S152e-27120
NC_017338:1234077:124796312479631248232270Staphylococcus aureus subsp. aureus JKD6159 chromosome, complete30S ribosomal protein S152e-27120
NC_017341:1291583:130777713077771308046270Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,30S ribosomal protein S152e-27120
NC_008262:1835613:184775518477551848018264Clostridium perfringens SM101, complete genomeribosomal protein S152e-27120
NC_008261:2157713:217370721737072173970264Clostridium perfringens ATCC 13124, complete genomeribosomal protein S152e-27120
NC_003997:3617000:362175736217573622026270Bacillus anthracis str. Ames, complete genome30S ribosomal protein S157e-27119
NC_005957:3638750:364342836434283643697270Bacillus thuringiensis serovar konkukian str. 97-27, complete30S ribosomal protein S157e-27119
NC_012472:3661912:366659036665903666859270Bacillus cereus 03BB102, complete genome30S ribosomal protein S157e-27119
NC_011772:3787500:379218637921863792455270Bacillus cereus G9842, complete genomeribosomal protein S157e-27119
NC_008600:3643905:364858336485833648852270Bacillus thuringiensis str. Al Hakam, complete genomeribosomal protein S15 (30S ribosomal protein S15)7e-27119
NC_007530:3616828:362188436218843622153270Bacillus anthracis str. 'Ames Ancestor', complete genome30S ribosomal protein S157e-27119
NC_014335:3567931:357260935726093572878270Bacillus cereus biovar anthracis str. CI chromosome, complete30S ribosomal protein S157e-27119
NC_005945:3615623:362245236224523622721270Bacillus anthracis str. Sterne, complete genome30S ribosomal protein S157e-27119
NC_010184:3675424:368050536805053680774270Bacillus weihenstephanensis KBAB4, complete genomeribosomal protein S157e-27119
NC_003909:3587695:359448835944883594757270Bacillus cereus ATCC 10987, complete genome30S ribosomal protein S157e-27119
NC_004722:3777907:378258537825853782854270Bacillus cereus ATCC 14579, complete genome30S ribosomal protein S157e-27119
NC_006274:3697255:370231137023113702580270Bacillus cereus E33L, complete genome30S ribosomal protein S157e-27119
NC_017353:1699652:170374117037411704010270Staphylococcus lugdunensis N920143, complete genome30S ribosomal protein S158e-27119
NC_009674:2551759:255644625564462556715270Bacillus cytotoxicus NVH 391-98 chromosome, complete genome30S ribosomal protein S157e-27119
NC_011658:3603009:360980136098013610070270Bacillus cereus AH187 chromosome, complete genome30S ribosomal protein S157e-27119
NC_014657:944000:961647961647961913267Caldicellulosiruptor owensensis OL chromosome, complete genomeribosomal protein s154e-27119
NC_007908:1600244:160170516017051601971267Rhodoferax ferrireducens T118, complete genomeribosomal protein S155e-27119
NC_014328:1405484:141775214177521418015264Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeribosomal protein S156e-27119
NC_010001:3369500:336963333696333369899267Clostridium phytofermentans ISDg, complete genomeribosomal protein S157e-27119
NC_017208:3816753:382182038218203822089270Bacillus thuringiensis serovar chinensis CT-43 chromosome, complete30S ribosomal protein S157e-27119
NC_017200:3655496:366348736634873663756270Bacillus thuringiensis serovar finitimus YBT-020 chromosome,30S ribosomal protein S157e-27119
NC_016779:3579743:358442135844213584690270Bacillus cereus F837/76 chromosome, complete genome30S ribosomal protein S157e-27119
NC_016771:3555506:356229835622983562567270Bacillus cereus NC7401, complete genome30S ribosomal protein S157e-27119
NC_014171:3701051:370573037057303705999270Bacillus thuringiensis BMB171 chromosome, complete genomeribosomal protein S157e-27119
NC_012659:3617000:362178436217843622053270Bacillus anthracis str. A0248, complete genomeribosomal protein S157e-27119
NC_011969:3549000:355376335537633554032270Bacillus cereus Q1 chromosome, complete genome30S ribosomal protein S157e-27119
NC_011773:3651963:365664136566413656910270Bacillus cereus AH820 chromosome, complete genome30S ribosomal protein S157e-27119
NC_011725:3821789:382647038264703826739270Bacillus cereus B4264 chromosome, complete genome30S ribosomal protein S157e-27119
NC_009138:1843998:184399818439981844267270Herminiimonas arsenicoxydans, complete genome30S ribosomal subunit protein S151e-26118
NC_015563:1595500:161588016158801616146267Delftia sp. Cs1-4 chromosome, complete genome30S ribosomal protein S151e-26118
NC_008601:631504:641539641539641805267Francisella tularensis subsp. novicida U112, complete genome30S ribosomal protein S153e-26117
NC_011992:889985:891368891368891634267Acidovorax ebreus TPSY, complete genomeribosomal protein S152e-26117
NC_013446:1173377:118770011877001187966267Comamonas testosteroni CNB-2, complete genomeribosomal protein S152e-26117
NC_015696:1749863:176409317640931764359267Francisella sp. TX077308 chromosome, complete genome30S ribosomal protein S15p (S13e)4e-26116
NC_010336:213148:244886244886245152267Francisella philomiragia subsp. philomiragia ATCC 25017, complete30S ribosomal protein S154e-26116
NC_019815:114288:125275125275125544270Candidatus Kinetoplastibacterium crithidii (ex Angomonas deaneismall subunit ribosomal protein S154e-26116
NC_010520:2585014:260770226077022608016315Clostridium botulinum A3 str. Loch Maree, complete genomeribosomal protein S154e-26116
NC_010516:2511035:253317125331712533485315Clostridium botulinum B1 str. Okra, complete genomeribosomal protein S154e-26116
NC_012563:2680246:271945927194592719773315Clostridium botulinum A2 str. Kyoto, complete genomeribosomal protein S154e-26116
NC_009697:2394826:241697124169712417285315Clostridium botulinum A str. ATCC 19397 chromosome, complete30S ribosomal protein S154e-26116
NC_009698:2367171:238931623893162389630315Clostridium botulinum A str. Hall chromosome, complete genome30S ribosomal protein S154e-26116
NC_009699:2576500:259368525936852593999315Clostridium botulinum F str. Langeland chromosome, complete genome30S ribosomal protein S154e-26116
NC_012658:2584355:260314426031442603458315Clostridium botulinum Ba4 str. 657 chromosome, complete genome30S ribosomal protein S154e-26116
NC_009495:2524000:254494825449482545211264Clostridium botulinum A str. ATCC 3502 chromosome, complete genome30S ribosomal protein S153e-26116
NC_020291:1464500:147602114760211476284264Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome30S ribosomal protein S156e-26115
NC_004461:921364:954211954211954480270Staphylococcus epidermidis ATCC 12228, complete genome30S ribosomal protein S159e-26115
NC_011830:3904034:390646839064683906734267Desulfitobacterium hafniense DCB-2, complete genomeribosomal protein S153e-25114
NC_004459:1679335:168509216850921685361270Vibrio vulnificus CMCP6 chromosome I, complete sequence30S ribosomal protein S152e-25114
NC_005139:2731623:274436727443672744636270Vibrio vulnificus YJ016 chromosome I, complete sequence30S ribosomal protein S152e-25114
NC_014965:670115:675942675942676211270Vibrio vulnificus MO6-24/O chromosome I, complete sequence30S ribosomal protein S15p2e-25114
NC_007880:1456705:146756114675611467827267Francisella tularensis subsp. holarctica, complete genome30S ribosomal protein S154e-25113
NC_007517:1792000:179200117920011792267267Geobacter metallireducens GS-15, complete genomeribosomal protein S154e-25113
NC_009004:2055563:205872020587202059043324Lactococcus lactis subsp. cremoris MG1363, complete genome30S ribosomal protein S154e-25113
NC_008781:1507384:150738415073841507650267Polaromonas naphthalenivorans CJ2, complete genomeribosomal protein S154e-25113
NC_006570:707280:717673717673717939267Francisella tularensis subsp. tularensis Schu 4, complete genome30S ribosomal protein S153e-25113
NC_008245:707984:717625717625717891267Francisella tularensis subsp. tularensis FSC 198, complete genome30S ribosomal protein S153e-25113
NC_016933:783938:793579793579793845267Francisella tularensis TIGB03 chromosome, complete genome30S ribosomal protein S153e-25113
NC_016937:707279:717672717672717938267Francisella tularensis subsp. tularensis TI0902 chromosome,30S ribosomal protein S153e-25113
NC_014152:1430156:144890014489001449169270Thermincola sp. JR, complete genomeribosomal protein S153e-25113
NC_009253:2139379:214267021426702142939270Desulfotomaculum reducens MI-1 chromosome, complete genome30S ribosomal protein S153e-25113
NC_014098:1553900:155687815568781557147270Bacillus tusciae DSM 2912 chromosome, complete genomeribosomal protein S156e-25112
NC_009483:2201986:220877122087712209037267Geobacter uraniireducens Rf4 chromosome, complete genome30S ribosomal protein S156e-25112
NC_019970:1343670:134793713479371348239303Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeribosomal protein S155e-25112
NC_015681:1685672:170474617047461705015270Thermodesulfatator indicus DSM 15286 chromosome, complete genome30S ribosomal protein S152e-24110
NC_004129:957890:977481977481977750270Pseudomonas fluorescens Pf-5, complete genome30S ribosomal protein S154e-24109
NC_008309:502983:508639508639508908270Haemophilus somnus 129PT, complete genome30S ribosomal protein S156e-24109
NC_013939:1535071:154270815427081542977270Deferribacter desulfuricans SSM1, complete genome30S ribosomal protein S151e-23108
NC_013216:3376186:338251633825163382785270Desulfotomaculum acetoxidans DSM 771, complete genomeribosomal protein S151e-23108
NC_021150:4311902:431750443175044317773270Azotobacter vinelandii CA6, complete genome30S ribosomal protein S159e-24108
NC_012560:4311906:431750843175084317777270Azotobacter vinelandii DJ, complete genomeribosomal protein S159e-24108
NC_011661:1143787:116306411630641163333270Dictyoglomus turgidum DSM 6724, complete genomeribosomal protein S158e-24108
NC_014758:1349494:135456513545651354834270Calditerrivibrio nitroreducens DSM 19672 chromosome, completeSSU ribosomal protein s15p3e-23107
NC_007645:1245927:125571112557111255980270Hahella chejuensis KCTC 2396, complete genomeribosomal protein S153e-23107
NC_015875:1505034:152655715265571526826270Streptococcus pseudopneumoniae IS7493 chromosome, complete genome30S ribosomal protein S152e-23107
NC_012880:3915500:391567739156773915946270Dickeya dadantii Ech703, complete genomeribosomal protein S155e-23106
NC_014833:2988814:300197130019713002237267Ruminococcus albus 7 chromosome, complete genome30S ribosomal protein S155e-23106
NC_018750:5828000:582983958298395830129291Streptomyces venezuelae ATCC 10712, complete genomeSSU ribosomal protein S15p6e-23105
NC_014656:1956277:196870619687061968975270Bifidobacterium longum subsp. longum BBMN68 chromosome, complete30S ribosomal protein S159e-23105
NC_011593:2504671:250970925097092509978270Bifidobacterium longum subsp. infantis ATCC 15697 chromosome,30S ribosomal protein S152e-22104
NC_017221:179272:201926201926202195270Bifidobacterium longum subsp. longum KACC 91563 chromosome,30S ribosomal protein S152e-22104
NC_011244:863306:872592872592872933342Borrelia recurrentis A1, complete genome30S ribosomal protein S151e-22104
NC_011728:832073:844550844550844816267Borrelia burgdorferi ZS7, complete genome30S ribosomal protein S151e-22104
NC_008343:2589680:261089726108972611166270Granulibacter bethesdensis CGDNIH1, complete genomeSSU ribosomal protein S15P2e-22103
NC_004342:929033:941007941007941297291Leptospira interrogans serovar Lai str. 56601 chromosome I,ribosomal protein S153e-22103
NC_016632:74569:828988289883167270Serratia symbiotica str. 'Cinara cedri' chromosome, complete30S ribosomal protein S153e-22103
NC_005823:3280000:328850632885063288772267Leptospira interrogans serovar Copenhageni str. Fiocruz L1-13030S ribosomal protein S153e-22103
NC_015186:597695:603489603489603758270Acidiphilium multivorum AIU301, complete genome30S ribosomal protein S156e-22102
NC_009484:489398:494542494542494811270Acidiphilium cryptum JF-5 chromosome, complete genome30S ribosomal protein S156e-22102
NC_004307:1936725:195139419513941951663270Bifidobacterium longum NCC2705, complete genome30S ribosomal protein S155e-22102
NC_015067:2032271:203710820371082037377270Bifidobacterium longum subsp. longum JCM 1217, complete genome30S ribosomal protein S155e-22102
NC_015052:2071759:207659720765972076866270Bifidobacterium longum subsp. infantis 157F, complete genome30S ribosomal protein S155e-22102
NC_010816:1989868:200251920025192002788270Bifidobacterium longum DJO10A, complete genomeRibosomal protein S155e-22102
NC_013522:736339:750592750592750858267Thermanaerovibrio acidaminovorans DSM 6589, complete genomeribosomal protein S152e-21100
NC_012440:197728:216824216824217108285Persephonella marina EX-H1, complete genomeribosomal protein S155e-2199.8
NC_020075:114790:129738129738130007270Candidatus Blochmannia chromaiodes str. 640, complete genome30S ribosomal protein S152e-2097.4
NC_015161:36668:491754917549450276Deinococcus proteolyticus MRP chromosome, complete genomeribosomal protein S159e-2095.5
NC_013943:1381000:139393113939311394200270Denitrovibrio acetiphilus DSM 12809 chromosome, complete genome30S ribosomal protein S151e-1995.5
NC_017259:388000:396537396537396806270Buchnera aphidicola str. Ua (Uroleucon ambrosiae) chromosome,30S ribosomal protein S151e-1995.1
NC_013861:311908:332732332732333007276Legionella longbeachae NSW150, complete genome30S ribosomal protein S154e-1993.6
NC_010730:813534:830345830345830632288Sulfurihydrogenibium sp. YO3AOP1, complete genomeribosomal protein S152e-1890.9
NC_004545:392685:395007395007395276270Buchnera aphidicola str. Bp (Baizongia pistaciae), complete genome30S ribosomal protein S152e-1890.9
NC_004113:1234048:125182212518221252097276Thermosynechococcus elongatus BP-1, complete genome30S ribosomal protein S155e-1889.7
NC_002528:404545:413873413873414142270Buchnera aphidicola str. APS (Acyrthosiphon pisum), complete30S ribosomal protein S155e-1889.7
NC_015557:114648:130578130578130853276Hydrogenobaculum sp. 3684 chromosome, complete genomeribosomal protein S156e-1889.4
NC_020411:114683:130613130613130888276Hydrogenobaculum sp. HO, complete genomeribosomal protein S156e-1889.4
NC_015587:114684:130614130614130889276Hydrogenobaculum sp. SHO chromosome, complete genomeribosomal protein S156e-1889.4
NC_010003:605961:618957618957619232276Petrotoga mobilis SJ95, complete genomeribosomal protein S151e-1788.2
NC_015672:1566565:157426815742681574537270Flexistipes sinusarabici DSM 4947 chromosome, complete genome30S ribosomal protein S156e-1785.9
NC_007799:727798:737989737989738270282Ehrlichia chaffeensis str. Arkansas, complete genomeribosomal protein S151e-1685.1
NC_005295:607319:613292613292613573282Ehrlichia ruminantium str. Welgevonden, complete genome30S ribosomal protein S156e-1682.8
NC_006831:583094:589070589070589351282Ehrlichia ruminantium str. Gardel, complete genome30S ribosomal protein S156e-1682.8
NC_006832:587162:593134593134593415282Ehrlichia ruminantium str. Welgevonden, complete genome30S ribosomal protein S156e-1682.8
NC_005043:1143557:114859011485901148859270Chlamydophila pneumoniae TW-183, complete genome30S ribosomal protein S155e-1682.8
NC_000922:1147855:115288811528881153157270Chlamydophila pneumoniae CWL029, complete genome30S ribosomal protein S155e-1682.8
NC_002179:904518:918257918257918526270Chlamydophila pneumoniae AR39, complete genome30S ribosomal protein S155e-1682.8
NC_002491:1147169:114929411492941149563270Chlamydophila pneumoniae J138, complete genome30S ribosomal protein S155e-1682.8
NC_016510:871000:875125875125875394270Flavobacterium columnare ATCC 49512 chromosome, complete genome30S ribosomal protein S155e-1682.8
NC_017285:913000:925424925424925693270Chlamydophila pneumoniae LPCoLN chromosome, complete genome30S ribosomal protein S155e-1682.8
NC_005061:96536:116984116984117256273Candidatus Blochmannia floridanus, complete genome30S ribosomal subunit protein S156e-1682.8
NC_012985:465354:476758476758477027270Candidatus Liberibacter asiaticus str. psy62, complete genome30S ribosomal protein S151e-1582
NC_014909:121771:121771121771122040270Candidatus Blochmannia vafer str. BVAF chromosome, complete genome30S ribosomal protein S156e-1579.3
NC_007516:1086948:109277310927731093042270Synechococcus sp. CC9605, complete genomeribosomal protein S151e-1478.2
NC_006361:4098469:410261041026104102879270Nocardia farcinica IFM 10152, complete genomeputative ribosomal protein S153e-1477
NC_014774:239865:247349247349247618270Candidatus Liberibacter solanacearum CLso-ZC1 chromosome, complete30S ribosomal protein S156e-1476.3
NC_014014:153837:158465158465158731267Mycoplasma crocodyli MP145 chromosome, complete genome30S ribosomal protein S157e-1372.4
NC_016893:563890:579738579738580010273Wigglesworthia glossinidia endosymbiont of Glossina morsitans30S ribosomal protein S153e-1167
NC_015380:303215:307830307830308099270Candidatus Pelagibacter sp. IMCC9063 chromosome, complete genomeSSU ribosomal protein S15p (S13e)1e-1065.1
NC_010118:207843:210045210045210281237Candidatus Sulcia muelleri GWSS, complete genome30S ribosomal protein S152e-1064.7
NC_004344:257471:263372263372263641270Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis,hypothetical protein2e-0961.2
NC_010741:949732:966643966643966912270Treponema pallidum subsp. pallidum SS14, complete genomeribosomal protein S152e-0960.8
NC_000919:948287:965198965198965467270Treponema pallidum subsp. pallidum str. Nichols, complete genomeribosomal protein S15 (rpsO)2e-0960.8
NC_016842:949899:966810966810967079270Treponema pallidum subsp. pertenue str. SamoaD chromosome, complete30S ribosomal protein S152e-0960.8
NC_016843:950000:966918966918967187270Treponema pallidum subsp. pertenue str. Gauthier chromosome,30S ribosomal protein S152e-0960.8
NC_016844:950231:967142967142967411270Treponema pallidum subsp. pallidum DAL-1 chromosome, complete30S ribosomal protein S152e-0960.8
NC_016848:950353:967264967264967533270Treponema pallidum subsp. pertenue str. CDC2 chromosome, complete30S ribosomal protein S152e-0960.8
NC_017268:949543:966454966454966723270Treponema pallidum subsp. pallidum str. Chicago chromosome,30S ribosomal protein S152e-0960.8
NC_021508:949769:966680966680966949270Treponema pallidum subsp. pallidum SS14, complete genomeribosomal protein S152e-0960.8
NC_015714:943178:960089960089960358270Treponema paraluiscuniculi Cuniculi A chromosome, complete genome30S ribosomal protein S152e-0960.8